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| 1 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | ADINA theory and modeling guide显示文摘 | Adina R&D Inc | 2001 | Watertown MA2001，，： | 1 |
| 3 | Ultrasound as a eatalyzer of aqueous reaction systems: the state of the art and environmental applications显示文摘 | Ince N H Tezcanli G Belen R K | 2001 | Applied Catalysis B: Environmental2001，29，3： | 1 |
| 4 | ADINA Theory and Modeling guide显示文摘 | ADINA R & D Inc | 2005 | Volumel:ADINA Solid & Structures2005，，： | 1 |
| 5 | Catalysis of advanced oxidation reactions by ultrasound: A case study with phenol 显示文摘 | Kidak R Ince N H | 2007 | Journal of Hazardous Materials2007，146，3： | 1 |
| 6 | Ultrasound as a Catalyzer of Aqueous Reaction Systems:The State of the Art and Environmental Applications 显示文摘 | Ince N H Tezcanli G Belen R K | 2001 | Applied Cataly- sis B : Environ2001，，29： | 1 |
| 7 | The 'Flowing' Gas Material Balance显示文摘 | Mattar L McNeil R Fekete Associates Inc | 1998 | JCPT1998，，2： | 1 |
| 8 | Ultrasound as acatalyzer of aqueous reaction systems:the state of the artand environmental applications显示文摘 | Ince N H Tezcanli G Belen R K | 2001 | Applied Catalysis B:En-vironmental2001，，29： | 1 |
| 9 | Tracking human motion in structured environment using adistributed-camera system 显示文摘 | Cai Q Aggarwal J K Inc R | 1999 | IEEE Transactions on Pattern Analysis and Machine Intelligence1999，21，11： | 1 |
| 10 | Isolation and preliminary evaluation of mycoparasites as biocontrol agents against crown rot of banana显示文摘 | Krauss U Bidwell R Ince J | 1998 | Biological Control-Theory and Application1998，13，： | 1 |
| 11 | Parkinsons disease in 65 pairs of twins and in a set of quadruplets显示文摘 | Ward C D Duvoisin R Cv Ince S E NuttJ D Eldridge R Calne D B | 1983 | Neurology1983，33，： | 1 |
| 12 | Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock显示文摘 | Fries M Ince C Rossaint R | 2008 | Crit Care Med2008，36，6： | 1 |
| 13 | Dolichoectasia of the intracranial arteries in patients with first ischemic stroke:A population based study 显示文摘 | INCE B PETTY G W BROWN R D | 1998 | Neurology1998，50，： | 1 |
| 14 | Clinical profiles and outcomes of acute type B aortic dissection in the current era: lessons from the International Reg istry of Aortic Dissection (IRAD) 显示文摘 | SUZUKI T MEHTA R H INCE H | 2003 | Circulation2003，108，： | 1 |
| 15 | Crystal diffraction grating in LiNbO3:Fe derived from interferometric volume holography显示文摘 | Ince R Yukselici H Ince AT | 2006 | Optics and Lasers in Engineering2006，44，6： | 1 |
| 16 | Prediction of fracture parameters of concrete by Artificial Neural Networks 显示文摘 | INCE R | 2004 | Engineering Fracture Mechanics2004，71，15： | 1 |
| 17 | 滑槽淬火系统的推荐设计显示文摘目前,聚合物淬火剂(quenchant)在各类热处理中的应用日益增加,其中包括某些具备滑槽(chute)淬火装置的连续炉系统。滑槽淬火的成功运用依赖于淬火剂的使用量和搅拌的均匀性。本文提供了一系列推荐的设计指导原则及一些已成功运用的滑槽淬火装置的示意图例。 | G E Totten,G M Webster(Union Crbide Corporation,Tarrytown,NY ) R R Blackwood,L M Jarvis(Tenaxol Inc,Milwaukee,WL) T Narumi(Nagase Chemspec Ltd,Tokyo,Japan) | 1998 | 金属热处理1998，23，1： | 1 |
| 18 | Isolation and preliminary evaluation of mycoparasites as biocontrol agents against crown rot of banana显示文摘 | Krauss U Bidell R Ince J | 1998 | Biological Control-Theory and Application1998，13，： | 1 |
| 19 | Ultrasound as a catalyzer of aqueous reaction system:the state of the art and environmental application显示文摘 | Ince N H Tezcanli G Belen R K | 2001 | Appl Catal B:Environ2001，29，： | 1 |
| 20 | Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock显示文摘 | Fries M Ince C Rossaint R | 2008 | Crit Care Med2008，36，6： | 1 |
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