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| 1 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | Direct observation of the human cerebral microcirculation during aneurysm surgery reveals in- creased arteriolar contractility 显示文摘 | PENNINGS F A BOUMA G J INCE C | 2004 | Stroke2004，35，6： | 1 |
| 3 | Assessment of toxic interactions of heavy metals in binary mixtures: A statistical approach显示文摘 | Ince N H Dirilgen I G Tezcanli A G | 1999 | Arch Environ Contamn Toxicol1999，36，： | 1 |
| 4 | Polymorphic microsatellite markers transferable across Capsicum species 显示文摘 | INCE A G KARACA M ONUS A N | 2010 | Plant Molecular Biology Reporter2010，28，： | 1 |
| 5 | Assessment of toxic interactions of heavy metals in binary mixtures: A statistical approach 显示文摘 | Ince N H Dirilgen I G Tezcanli A G | 1999 | Archives of Environmental Contamination and Toxicology1999，36，4： | 1 |
| 6 | Assessment of toxic interactions of heavy metals in binary mixtures: A statistical approach显示文摘 | Ince N H Dirilgen I G Tezcanli A G | 1999 | Arch Environ contamn toxicol1999，36，： | 1 |
| 7 | Assessment of toxic interactions of heavy metals in binary mixtures:a statistical approach显示文摘 | INCE N H DIRILGEN I G TEZCANLI A G | 1999 | Archive of Environmental Contamination and Toxicology1999，36，： | 1 |
| 8 | Development and utilization of diagnostic DAMD-PCR markers for Capsicum accessions 显示文摘 | Ince A G Karaea M Onus A N | 2009 | Genetic Resources and Crop Evolution2009，56，2： | 1 |
| 9 | Polymorphic microsatellite mark- ers transferable across capsicum species 显示文摘 | Ince A G Karaca M Onus A N | 2010 | Plant Mol Biol Rep2010，28，2： | 1 |
| 10 | Genetic relationships within and between capsicum species 显示文摘 | Ince A G Karaca M Onus A N | 2010 | Biochemical Genetics2010，48，12： | 1 |
| 11 | Polymorphic microsatellite markers transferable across Capsicum species 显示文摘 | INCE A G KARACA M ONUS A N | 2010 | Plant Mol Biol Rep2010，28，： | 1 |
| 12 | Assessment of toxic interactions of heavy metals in binary mixtures:A statistical approach 显示文摘 | INCE N H DIRILGEN I G TEZCANLI A G | 1999 | Arch Environ Contamn Toxicol1999，36，： | 1 |
| 13 | Assessment of toxicinteractions of heavy metals in binary mixtures: A statisticalapproach显示文摘 | Ince N H Dirilgen I G Tezcanli A G | 1999 | Arch Environ Contamn Toxicol1999，36，： | 1 |
| 14 | Computational modeling of mul- tiaxial elasto-plastic stress-strain response for notched compo- nents under non-proportional loading 显示文摘 | Ince A Glinka G Buczynski A | 2014 | International Journal of Fatigue2014，62，： | 1 |
| 15 | Microcirculation in sepsis new perspectives显示文摘 | Hernandez G Bruhn A Ince C | 2013 | Curr Vasc Pharmacol2013，11，2： | 1 |
| 16 | Bacteraemia and candidaemia: a considerable and underestimated complication of severe rotavirus gastroenteritis显示文摘 | Ciftci E Tapisiz A Ozdemir H G ii riz H Kendirli T Ince E | 2009 | Scand 1 Infect Dis2009，41，1112： | 1 |
| 17 | Assessment of toxic interactions of heavy metals in binary mixtures:A statistical approach显示文摘 | DIRILGEN I G TEZCANLI A G | 1999 | Arch Environ Contamn Taxicol1999，36，： | 1 |
| 18 | Dendrite development regulated by CREST,a calcium-regulated transcriptional activator显示文摘 | Aizawa H Hu S C Bobb K Balakrishnan K Ince G Gurevich I Cowan M Ghosh A | | 0，，5655： | 1 |
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