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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | Nutritional therapy for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most frequent primary liver cancer and presents together with cirrhosis in most cases.In addition to commonly recognized risk factors for HCC development,such as hepatitis B virus/hepatitis C virus infection,age and alcohol/tobacco consumption,there are nutritional risk factors also related to HCC development including high intake of saturated fats derived from red meat,type of cooking(generation of heterocyclic amines)and contamination of foods with aflatoxins.On the contrary,protective nutritional factors include diets rich in fiber,fruits and vegetables,n-3 polyunsaturated fatty acids and coffee.While the patient is being evaluated for staging and treatment of HCC,special attention should be paid to nutritional support,including proper nutritional assessment and therapy by a multidisciplinary team.It must be considered that these patients usually develop HCC on top of long-lasting cirrhosis,and therefore they could present with severe malnutrition.Cirrhosisrelated complications should be properly addressed and considered for nutritional care.In addition to traditional methods,functional testing,phase angle and computed tomography scan derived skeletal muscle index-L3 are among the most useful tools for nutritional assessment.Nutritional therapy should be centered on providing enough energy and protein to manage the increased requirements of both cirrhosis and cancer.Supplementation with branched-chain amino acids is also recommended as it improves response to treatment,nutritional status and survival,and finally physical exercise must be encouraged and adapted to individual needs. | Astrid Ruiz-Margáin Berenice M Román-Calleja Paulina Moreno-Guillén JoséA González-Regueiro DeyaniraKúsulas-Delint Alejandro Campos-Murguía Nayelli C Flores-García Ricardo Ulises Macías-Rodríguez | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 4 |
| 3 | Outcome in obscure gastrointestinal bleeding after capsule endoscopy显示文摘AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions. | Alex Caas-Ventura Lucia Márque Xavier Bessa Josep Maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 4 |
| 4 | Modeling contaminant transport in homogeneous porous media with fractional advection-dispersion equation显示文摘The newly developed Fractional Advection-Dispersion Equation (FADE), which is FADE was extended and used in this paper for modelling adsorbing contaminant transport by adding an adsorbing term. A parameter estimation method and its corresponding FORTRAN based program named FADEMain were developed on the basis of Nonlinear Least Square Algorithm and the analytical solution for one-dimensional FADE under the conditions of step input and steady state flow. Data sets of adsorbing contaminants Cd and NH4+-N transport in short homogeneous soil columns and conservative solute NaCI transport in a long homogeneous soil column, respectively were used to estimate the transport parameters both by FADEMain and the advection-dispersion equation (ADE) based program CXTFIT2.1. Results indicated that the concentration simulated by FADE agreed well with the measured data. Compared to the ADE model, FADE can provide better simulation for the concentration in the initial lower concentration part and the late higher concentration part of the breakthrough curves for both adsorbing contaminants. The dispersion coefficients for ADE were from 0.13 to 7.06 cm2/min, while the dispersion coefficients for FADE ranged from 0.119 to 3.05 cm1.856/min for NaCI transport in the long homogeneous soil column. We found that the dispersion coefficient of FADE increased with the transport distance, and the relationship between them can be quantified with an exponential function. Less scale-dependent was also found for the dispersion coefficient of FADE with respect to ADE. | HUANG Guanhua, HUANG Quanzhong, ZHAN Hongbin , CHEN Jing, XIONG Yunwu & FENG Shaoyuan College of Hydraulic and Civil Engineering, China Agricultural University, Beijing 100083, China Chinese-Israeli International Center for Research and Training in Agriculture, Beijing 100083, China Department of Geology and Geophysics, Texas A& M University, TZ77843-3115, USA | 2005 | Science China Earth Sciences2005，48，z2： | 3 |
| 5 | A randomised multicentre trial显示文摘 | Saunders M Dische S Barrett A et aL Continuous hyperfractionaed accelerated radiotherapy(CHART)versus conventional radiotherapy in non-small-cell lung cancer | 1997 | Lancet1997，350，9072： | 1 |
| 6 | Sclerotherapy with bleomycin does not adversely affect facial nerve function in children with cervicofacial cystic lymphatic malformation显示文摘 | Karavelioglu A Temu(c)in C M Tanyel F C | 2010 | J Pediatr Surg2010，45，8： | 1 |
| 7 | Protein kinase C mediates basie fibroblast growth factor pm- lection of endothelial cells against radiation - induced apoptosis 显示文摘 | HAIMOVlTZ FRIEDMAN A BALABAN N MCI OUGHI IN M el al | 1994 | Cancer Res1994，54，10： | 1 |
| 8 | Corporate executives and environmentalscanning activities: an empirical investigation显示文摘 | HAGEN A F A M IN S G | 1995 | SAM Advanced Management Journal1995，60，2： | 1 |
| 9 | Tire rubber-sisal composites: Effect of mercerization and acetylation on reinforcement显示文摘 | Maria A M Ines J | 2003 | Journal of Applied Polymer Science2003，89，9： | 1 |
| 10 | but not in cell cultures of Centaurium erythraea RAFN 显示文摘 | Abd E1-Mawla A M Schmidt W Beerhues L Cinnamic acid is a precursor of benzoic acids in cell cultures of Hype-ricum and rosaemum L | 2001 | Planta2001，，212： | 1 |
| 11 | Multifractal scaling of soil spatial variability显示文摘 | CANIEGO F J ESPEJO R MART′IN M A | 2005 | Ecological Modelling2005，182，34： | 1 |
| 12 | Part I:presentation of the model显示文摘 | Thome J R Dupont V Jacobi A M Heat transfer model for evaporation in microchannels | 2004 | Int J Heat Mass Transfer2004，47，1416： | 1 |
| 13 | New Static Var Compensator Control Strategy and Coordina- tion with Under-load Tap Changer显示文摘 | Flexible AC Transmission Sys- in England by TJ lnternation ABDEL-RAHMAN M H YOUSSEF F M H SABER A A | 2006 | IEEE Transactions on Power Delivery2006，21，3： | 1 |
| 14 | With- drawal ofa novel - design duodenoscope ends outbreak of a VIM - 2 - producing Pseudomonas aeruginosa 显示文摘 | Verfaillie C J Bruno M J F Voor In I Hoh A el al | 2015 | Endosco-gy2015，47，6： | 1 |
| 15 | Endoscopy显示文摘 | Gay G Delvaux M Rey J E The role of video capsule endoscopy in the diagnosis of digestive diseases: a review of current possibilities | 2004 | Endoscopy2004，36，4： | 1 |
| 16 | 显示文摘 | Pavlostathis S G Gossett J M A preliminary conversion mechanisms in anaerobic digestion of biological sludges | 1986 | Journal of Environmental Engineering ASCE1986，，114： | 1 |
| 17 | Role of geranylgeranylation and Rho proteins显示文摘 | Essig M Nguyen G Prie D et aL 3-Hydroxy-3-methyl glutaryl coenzyme A reductase inhibittors increase fibrinolytic activity in rat aorticendothelial cell s | 1998 | Circ Res1998，83，7： | 1 |
| 18 | Evidence of a cultured strain of the marine rhathymum from Malaysia 显示文摘 | Cailaud A de la Iglesia P okadaic acid production in dinoflagellate Prorocentrum Campers M | 2010 | Toxieon2010，55，： | 1 |
| 19 | A pilot study显示文摘 | de Tayrac R Aires A Therin M Collagen - coated vs noncoated low-weight polypropylene meshes in a sheep model for vaginal surgery | 2007 | Int Urogyneeol J Pelvic Floor Dysfunct2007，18，5： | 1 |
| 20 | Boothroyd C 显示文摘 | Smith CA de Lacey S Chapman M Acupuncture to im- prove live birth rates for women undergoing in vitro fertilization : a protocol for a randomized controlled trial | 2012 | Trials2012，13，： | 1 |
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