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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Age and menopausal status are important factors influencing the serum human epididymis secretory protein 4 level:a prospective cross-sectional study in healthy Chinese people显示文摘Background::Human epididymis secretory protein 4(HE4)is a new ovarian cancer biomarker.The factors influencing HE4 levels are not clear,and the reference data in China are limited.Here,we aim to evaluate the effects of menopause and age on HE4 levels and to provide a possible reference value for HE4 in healthy Chinese people.Methods::A total of 2493 healthy females aged 40 years or older were recruited from March 2013 to March 2017 with the cooperation of four medical institutions across Beijing,China.The serum levels of HE4 and cancer antigen 125(CA125)were measured by enzyme-linked immunosorbent assay.The Wilcoxon rank-sum test of variance and a stratified analysis were used to analyze the relationships among age,menopausal status,and levels of HE4 or CA125.Confidence intervals(5%-95%)were determined for reference ranges in different populations.Results::There was a statistically significant difference in median HE4 levels between the post-menopausal(n=2168)and premenopausal groups(n=325)(36.46 vs.24.04 pmol/L,Z=-14.41,P<0.001).HE4 increased significantly with age in the post-menopausal groups(H=408.18,P<0.001)but not in the pre-menopausal subjects(Z=-0.43,P=0.67).The upper 95th percentile of HE4 levels were 44.63 pmol/L for pre-menopausal women,78.17 pmol/L for post-menopausal women,and 73.3 pmol/L for all women.In the post-menopausal population,the HE4 reference ranges were 13.15 to 47.31,14.31 to 58.04,17.06 to 73.51,24.50 to 115.25,and 35.71 to 212.37 pmol/L for different age groups from forty divided by decade.The CA125 level was affected mainly by menopausal status and not age.Conclusions::Menopausal status and age were both important factors influencing the level of HE4,and age affected HE4 levels mainly in post-menopausal women.The HE4 level was higher in the post-menopausal population than in the pre-menopausal population and increased with age. | Hong-Yan Cheng Lin Zeng Xue Ye Rui-Qiong M a Zhi-Jian Tang Hong-Ling Chu Yi-M ing Zhao Li-Rong Zhu Yu-Nong Gao Xiao-Hong Chang Heng Cui | 2020 | Chinese Medical Journal2020，，11： | 6 |
| 3 | TLR3 and TLR4 expression in healthy and diseased human endometrium显示文摘 | Allhorn S B(o)ing C Koch A A | 2008 | Reprod Biol Endocrinol2008，6，： | 1 |
| 4 | The effects of trust and interde pendenee on relationship commitment: A trans-Athantie study 显示文摘 | INGE GEYSKENSA JAN-BENEDICT E M STEENKAMPB A LISA K SCHEERC | 1996 | Int J Res Marketing1996，13，4： | 1 |
| 5 | Genotyping of Streptococcus agalactiae (group B streptococci ) isolated from vaginal and rectal swabs of women at 35 - 37 weeks of pregnancy显示文摘 | Nabil A E A Inge T Greert C | 2009 | BMC Infectious Diseases2009，9，： | 1 |
| 6 | How social and human capital influence opportunity recognition and resource mobilization in India's handloom industry 显示文摘 | Bhawavatula S Elfi'ing T Tilbu A | 2010 | Journal of Business Venturing2010，25，3： | 1 |
| 7 | Stimuli-responsive magnetic nanomicelles as multifunctional heat and cargo delivery vehicles 显示文摘 | Kim D H Vitol E A Liu | 2013 | Langmuir2013，29，24： | 1 |
| 8 | Evaluation of 99mTc-UBI 29-41 scintigraphy for specific detection of experimental Staphylococcus aureus prosthetic joint infections显示文摘 | Sarda-Mantel L Saleh-Mghir A Wel ing MM | | 0，，08： | 1 |
| 9 | Pulmonary artery stents in the recent era: immediate and intermediate follow-up 显示文摘 | Ing FF Khan A Kobayashi D | 2014 | Catheter Cardiovasc Interv2014，84，7： | 1 |
| 10 | Inhibition of microparticle release triggers endothelial cell apoptosis and detachment显示文摘 | Abid Hussein MN Bing AN Sturk A | 2007 | Thromb Haemost2007，98，5： | 1 |
| 11 | Pedagogical content knowing:An integrative model for teacher preparation显示文摘 | Cochran K F DeRuiter J A&K ing R A | 1993 | Journal ofTeacher Education1993，，4： | 1 |
| 12 | Adherence influences monocyte responsiveness to interleukin - 10 显示文摘 | PETIT BERTRON A F FITI'ING C CAVAILLON J M | 2003 | J Leukoe Biol2003，73，1： | 1 |
| 13 | Nicotine phar- macokinetics and its application to intake from smoking 显示文摘 | FEYERABEND C INGS R M RUSSEL M A | 1985 | Br J Clin Pharmacol1985，19，2： | 1 |
| 14 | Enzymatic hydrolysis of brewers' spent grain proteins and technofunctional properties of the resulting hydrolysates显示文摘 | Inge Celus Kristof Brijs Jan A Delcour | 2007 | Journal of Agricultural and Food Chemistry2007，，21： | 1 |
| 15 | Production and isolation of chitosan from Mucor rouxii 显示文摘 | Stephen A White Peter R Farina Inge Fulton | 1979 | Appl Envir Microbiol1979，38，2： | 1 |
| 16 | Successful hobbing without coolant 显示文摘 | Dr Ing Mundt A | 1994 | Liebherr- Verzahntechnik GmbH1994，22，4： | 1 |
| 17 | Follicular helper T cells: new insights into mechanisms of autoimmune diseases 显示文摘 | Zhang X Ing S Fraser A | 2013 | Ochsner J2013，13，1： | 1 |
| 18 | Specific determinants of intrinsic work motivation,emotional exhaustion and turnover intention:A muhi-sample longitudinal study显示文摘 | Inge Houkes Janssen P M Jan de Jonge & Bakker A B | 2003 | Journal of Occupational and Organizational Psychology2003，，4： | 1 |
| 19 | Long- term differences in language and cognitive function after childhood exposure to anesthesia显示文摘 | ING C DIMAGGIO C WHITEHOUSE A | 2012 | Pediatrics2012，130，3： | 1 |
| 20 | TLR3 and TLR4 expression in healthy and diseased human endometrium显示文摘 | Allhorn S B(o)ing C Koch A A | 2008 | Reprod Biol Endocrinol2008，6，： | 1 |
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