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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Traumatic aortic rupture,30 years of experience显示文摘 | Cindy M Sabrina H Kim D Geert M Inge F | | 0，，： | 1 |
| 3 | Phylogenetic and pathogenic analyses show that the causal agent of apple ring rot in china is Botryosphaeria dothidea 显示文摘 | Tang W D ing Z Zhou Z Q | 2012 | Plant Disease2012，96，4： | 1 |
| 4 | Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development 显示文摘 | Leen D Jan P Inge V | 2009 | Hepatology2009，50，1： | 1 |
| 5 | Aetiological differences in neuroanatomy of the vegetative state: insights from diffusion tensor imaging and functional implications 显示文摘 | Newcombe VF Williams GB Scoff- ings D | 2010 | J Neurol Neurosurg Psychiatry2010，81，5： | 1 |
| 6 | Recent development in robotic stitching technology for textile structural composites显示文摘 | ING D WITHNG J | 2001 | JTATM2001，2，1： | 1 |
| 7 | On general principally injective rings显示文摘 | CHEN J L D ING N Q | 1999 | Comm ALGEBRA1999，27，5： | 1 |
| 8 | Space laser altimeter pointing bias calibra- tion from range residual analysis 显示文摘 | LUTHCKE S B ROWLANDS D D STONEK- ING E | 2000 | Journal of spacecraft and rockets2000，，： | 1 |
| 9 | Technical accuracy of a neuronavigation system measured with a high-precision mechanical micromanipulator显示文摘 | Kaus M Ing D Sporer T | | 0，，： | 1 |
| 10 | On the security of a visual cryptography scheme for color images显示文摘 | iNG F Y WONG D S | 2009 | Pattern Recognition2009，42，5： | 1 |
| 11 | Auto- matic Monitoring of Slope Deformations Using Geoteehnieal Instruments显示文摘 | l)ing X L Ren D Y Montgomery B | 2000 | Journal of Survey- ing Engineering-Asce2000，126，2： | 1 |
| 12 | No rmal physiology of copper metabo lism 显示文摘 | W inge D R | 1984 | Sem Liver D is1984，4，： | 1 |
| 13 | Molecularly targeted oncology therapeutics and prolongation of the QT interval 显示文摘 | Strevel EL Ing D J Siu LL | 2007 | J Clin Oncol2007，25，22： | 1 |
| 14 | Stimuli-responsive magnetic nanomicelles as multifunctional heat and cargo delivery vehicles 显示文摘 | Kim D H Vitol E A Liu | 2013 | Langmuir2013，29，24： | 1 |
| 15 | Detection and characterization of long pulse low velocity impact damage in plastic bonded explosives显示文摘 | Chen P W Huang F L Dai K D I)ing Y S | 2005 | International Journal of Impact Engineering2005，31，49： | 1 |
| 16 | Neonatal data on a cohort of 2889 infants born after ICSI (1991-1999) and of 2995 infants born after IVF (1983-1999)显示文摘 | Maryse B Inge L Veerle D | 2002 | Hum Reprod2002，17，3： | 1 |
| 17 | Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer显示文摘 | Schiller JH Han'ing D Belani CP | 2002 | N Engl J Med2002，346，2： | 1 |
| 18 | Pulmonary artery stents in the recent era: immediate and intermediate follow-up 显示文摘 | Ing FF Khan A Kobayashi D | 2014 | Catheter Cardiovasc Interv2014，84，7： | 1 |
| 19 | Modulation of cytokine- induced cardiac myocyte apoptosis by nitric oxide, Bak and Bcl-x显示文摘 | ING D J ZANG J DZAU V | 1999 | Circ Res1999，84，1： | 1 |
| 20 | Review of methods for in situ leaf area index determination显示文摘 | Inge Jonckheere Stefan Fleck Kris Nackaerts Bart Muys Pol Coppin Marie Weiss Frédéric Baret | 2003 | Agricultural and Forest Meteorology2003，，1： | 1 |
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