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| 1 | Generation of recombinant bacillus Calmette-Gu6rin and Mycobacterium smeg- matis expressing BfpA and intimin as vaccine vectors against entero- pathogenic Escherichia coli显示文摘 | Vasconcellos HL Scaramuzzi K Nascimento IP | 2012 | Vaccine2012，30，41： | 1 |
| 2 | Anti-proliferative and differentiation-inducing activities of the green tea catechin epigallocatechin-3-gallate(EGCG) on the human eosinophilic leukemia EoL-1 cell line显示文摘 | Lung HL Ip WK Wong CK | 2002 | Life Sciences2002，72，： | 1 |
| 3 | The functional sig- nificance of microRNA-29c in patients with colorectal cancer : a potential circulating biomarker for predicting early relapse显示文摘 | Yang IP Tsai HL Huang CW | 2013 | PLoS One2013，，66： | 1 |
| 4 | The functional signifi- cance of microRNA-29c in patients with colorectal can- cer: a potential circulating biomarker for predicting early relapse显示文摘 | Yang IP Tsai HL Huang CW | 2013 | PLoS One2013，8，66： | 1 |
| 5 | Generation ofrecombinant bacillus Calmette-Guerin and Mycobacterium smegma-tis expressing BQ)A and intimin as vaccine vectors against entero-pathogenic Escherichia coli 显示文摘 | Vasconcellos HL Scaramuzzi K Nascimento IP | 2012 | Vaccine2012，30，41： | 1 |
| 6 | Omparisons of responsiveness and predictive validity of two balance measures in strokeinpatients receiving rehabilitation 显示文摘 | Hsueh IP Mao HF Huang HL | 2001 | Formos J Med2001，5，： | 1 |
| 7 | The future of ischemic stroke: flow from prehospital neuroprotection to definitive reper- fusion显示文摘 | Ip HL Liebeskind DS | 2014 | Interventional Neurology2014，2，3： | 1 |
| 8 | Computational fluid dynamics modeling of symptomatic intracranial atherosclerosis may predict risk of stroke recurrence显示文摘 | Leng X Scalzo F Ip HL | 2014 | PLoS One2014，9，97： | 1 |
| 9 | Comparisons of responsiveness and predicitive validity of two balance measure in strokein inpatients receiving rehabilitation 显示文摘 | Hsuch IP Mao HF Huang HL | 2001 | Formos J Med2001，5，： | 1 |
| 10 | Development of a deregu- lating microRNA panel for the detection of early relapse in postoperative colorectal cancer patients 显示文摘 | Yang IP Tsai HL Miao ZF | 2016 | J Transl Med2016，14，1： | 1 |
| 11 | Interobserver reproducibility of signal intensity ratio on magnetic resonance angiography for hemodynamic impact of intracranial atherosclerosis显示文摘 | Leng X Ip HL Soo Y | 2013 | J Stroke Cerebrovasc Dis2013，22，： | 1 |
| 12 | Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells 显示文摘 | Lung HL Ip WK Chen ZY | 2004 | Int J Mol Med2004，13，3： | 1 |
| 13 | Visually-induced reorientation illusions as a function of age显示文摘 | Howard IP Jenkin HL | 2000 | Aviat Space Environ Med2000，71，9： | 1 |
| 14 | Computational fluid dynamics modeling of symptomatic intracranial atherosclerosis may predict risk of stroke recurrence显示文摘 | Leng X Scalzo F Ip HL | 2014 | PLoS One2014，9，97： | 1 |
| 15 | Omparisons of responsiveness and predictive validity of two balance measures in stroke inpatients receiving rehabilitation 显示文摘 | Hsueh IP Mao HF Huang HL | 2001 | Formos J Med2001，5，： | 1 |
| 16 | microRNA-93 inhibits tumor growth and early relapse of human colorectal cancer by affecting genes involved in the cell cycle显示文摘 | Yang IP Tsai HL Hou MF | 2012 | Carcinogenesis2012，33，8： | 1 |
| 17 | Generation of recombinant bacillus Calmette-Guérin and Mycobacterium smegma-tis expressing Bfp A and intimin as vaccine vectors against entero-pathogenic Escherichia coli显示文摘 | Vasconcellos HL Scaramuzzi K Nascimento IP | 2012 | Vaccine2012，30，41： | 1 |
| 18 | Clinical significance of microR- NA-148a in patients with early relapse of stage II stage and III color- ectal cancer ',filer curative resection 显示文摘 | Tsai HL Yang IP Huang CW | 2013 | Transl Res2013，162，4： | 1 |
| 19 | The functional significance of roi- cmRNA-29c in patients with colorectal cancer: a potential circulating biornarker for predicting early relapse 显示文摘 | Yang IP Tsai HL Huang CW | 2013 | PLoS One2013，8，66： | 1 |
| 20 | Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease显示文摘Objectives The predisposition of intracranial atherosclerotic disease(ICAD)to East Asians over Caucasians infers a genetic basis which,however,remains largely unknown.Higher prevalence of vascular risk factors(VRFs)in Chinese over Caucasian patients who had a stroke,and shared risk factors of ICAD with other stroke subtypes indicate genes related to VRFs and/or other stroke subtypes may also contribute to ICAD.Methods Unrelated symptomatic patients with ICAD were recruited for genome sequencing(GS,60-fold).Rare and potentially deleterious single-nucleotide variants(SNVs)and small insertions/deletions(InDels)were detected in genome-wide and correlated to genes related to VRFs and/or other stroke subtypes.Rare aneuploidies,copy number variants(CNVs)and chromosomal structural rearrangements were also investigated.Lastly,candidate genes were used for pathway and gene ontology enrichment analysis.Results Among 92 patients(mean age at stroke onset 61.0±9.3 years),GS identified likely ICAD-associated rare genomic variants in 54.3%(50/92)of patients.Forty-eight patients(52.2%,48/92)had 59 rare SNVs/InDels reported or predicted to be deleterious in genes related to VRFs and/or other stroke subtypes.None of the 59 rare variants were identified in local subjects without ICAD(n=126).31 SNVs/InDels were related to conventional VRFs,and 28 were discovered in genes related to other stroke subtypes.Our study also showed that rare CNVs(n=7)and structural rearrangement(a balanced translocation)were potentially related to ICAD in 8.7%(8/92)of patients.Lastly,candidate genes were significantly enriched in pathways related to lipoprotein metabolism and cellular lipid catabolic process.Conclusions Our GS study suggests a role of rare genomic variants with various variant types contributing to the development of ICAD in Chinese patients. | Mengmeng Shi Xinyi Leng Ying Li Zihan Chen Ye Cao Tiffany Chung Bonaventure YM Ip Vincent HL Ip Yannie OY Soo Florence SY Fan Sze Ho Ma Karen Ma Anne Y Y Chan Lisa WC Au Howan Leung Alexander Y Lau Vincent CT Mok Kwong Wai Choy Zirui Dong Thomas W Leung | 2022 | Stroke & Vascular Neurology2022，7，3： | 0 |
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