|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | <ce:link locator='fx1'/> A Review of Activity Indices and Efficacy End Points for Clinical Trials of Medical Therapy in Adults With Ulcerative Colitis显示文摘 | Geert D’Haens William J. Sandborn Brian G. Feagan Karel Geboes Stephen B. Hanauer E. Jan Irvine Marc Lémann Philippe Marteau Paul Rutgeerts Jurgen Sch?lmerich Lloyd R. Sutherland | 2007 | Gastroenterology2007，，2： | 2 |
| 2 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 3 | <ce:link locator='fx1'/> A Review of Activity Indices and Efficacy End Points for Clinical Trials of Medical Therapy in Adults With Ulcerative Colitis显示文摘 | Geert D'Haens William J. Sandborn Brian G. Feagan Karel Geboes Stephen B. Hanauer E. Jan Irvine Marc Lémann Philippe Marteau Paul Rutgeerts Jurgen Sch?lmerich Lloyd R. Sutherland | 2007 | Gastroenterology2007，，2： | 2 |
| 4 | Evaluation of a speetrophotometric assay for the measurement of malondialdehyde and 4-hydroxyalkenals in human spermatozoa: relationships with semen quality and sperm function 显示文摘 | Gomez E Irvine D S Aitken R J | 1998 | Int J Androl1998，21，2： | 1 |
| 5 | Evidence of deteriorating semen quality in the United Kingdom:birth cohort study in 577 men in Scotland over 11 years显示文摘 | Irvine S Cawood E Richardson D | 1996 | BMJ1996，312，7029： | 1 |
| 6 | Pokeweed antiviral protein inactivates pokeweed ribosomes implications for the antiviral mechanism显示文摘 | BONNESS M S READY M P IRVIN J D | 1994 | Plant J1994，5，2： | 1 |
| 7 | Implantable silk composite microneedles for programmable vaccine release ki- netics and enhanced immunogenicity in transcutaneous immu- nization显示文摘 | DEMUTH P C MIN Y IRVINE D J | 2014 | AdvHealthcMater2014，3，1： | 1 |
| 8 | DNA integrity in human spermatozoa : relationships with semen quality 显示文摘 | Irvine D S Twigg J P Gordon E L | 2000 | J Androl2000，21，1： | 1 |
| 9 | Hydrogen Titanates as Potential Proton Conducting Fuel Cell Electrolytes显示文摘 | Corcoran D J D Tunstall D P Irvine J T S | 2000 | Solid State Ionics2000，，： | 1 |
| 10 | The evolution of the brow lift in aesthetic plastic显示文摘 | Paul Malcolm D MD Irvine | 2001 | Plast Reconstr Surg2001，108，5： | 1 |
| 11 | Fire hazards and some common polymers 显示文摘 | IRVINE D J MCCLUSKEY J A ROBINSON I M | 2000 | Polym Degrad Stab2000，67，3： | 1 |
| 12 | The prevalence and correlates of fatigue in patients receiving treatment with chemotherapy and radiotherapy; A comparison with the fatigue experienced by healthy individuals显示文摘 | Irvine D Vincent L Graydon JE | 1994 | Cancer Nuts1994，17，5： | 1 |
| 13 | Assessment of mitral regurgitation显示文摘 | Irvine T Li X Sahn D | 2002 | Heart2002，88，： | 1 |
| 14 | Pokeweed antiviral protein isoforms PAP-I, PAP-II, and PAP-III depurinate RNA of human immunodeficiency virus(HIV)-I 显示文摘 | Rajamohan F Venkatachalam T K Irvin J D | 1999 | Biochem Biophys Res Commun1999，260，2： | 1 |
| 15 | Pokeweed antiviral protein isoforms PAP-Ⅰ, PAP-Ⅱ, and PAP-Ⅲ depurinate RNA of human immunodeficiency virus (HIV)-1 显示文摘 | RAJAMOHAN F VENKATACHALAM T K IRVIN J D | 1999 | Biochem Biophys Res Commun1999，260，2： | 1 |
| 16 | Argonaute slicing is required for heterochromatic silencing and spreading显示文摘 | Irvine D V Zaratigui M Tolia N H | 2006 | Science2006，313，5790： | 1 |
| 17 | Oxidation of phenolic pollutants by a lignin degrading enzyme from the white-rotfungus Phanerochaete chrysosporium显示文摘 | AITKEN M D VENKATADRI R IRVINE R L | 1989 | Water Research1989，23，4： | 1 |
| 18 | Precipitation and recovery of whey proteins显示文摘 | HILL A R IRVINE D M BULLOCK D H | 1982 | Canadian Institute of Food Science and Technology1982，15，： | 1 |
| 19 | Fatigue-reducing strategies used by patients receiving treatment for cancer显示文摘 | GRAYDON JE BUBELA N IRVINE D | 1995 | Cancer Nursing1995，18，1： | 1 |
| 20 | Fire hazards and some common polymers 显示文摘 | Irvine D J McCluskey J A Robinson I M | 2000 | Polymer Degradation and Stability2000，67，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员