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| 1 | Sessile serrated adenomas:Demographic,endoscopic and pathological characteristics显示文摘AIM:To study the demographic and endoscopic characteristics of patients with sessile serrated adenoma(SSA) in a single center.METHODS:Patients with SSA were identified by review of the pathology database of Mayo Clinic Arizona from 2005 to 2007.A retrospective chart review was performed to extract data on demographics,polyp characteristics,presence of synchronous adenomatous polyps or cancer,polypectomy methods,and related complications.RESULTS:One hundred and seventy-one(2.9%) of all patients undergoing colonoscopy had a total of 226 SSAs.The mean(SE) size of the SSAs was 8.1(0.4) mm;42% of SSAs were ≤ 5 mm,and 69% were ≤ 9 mm.Fifty-one per cent of SSAs were located in the cecum or ascending colon.Approximately half of the patients had synchronous polyps of other histological types,including hyperplastic and adenomatous polyps.Synchronous adenocarcinoma was present in seven(4%) cases.Ninety-seven percent of polyps were removed by colonoscopy.CONCLUSION:Among patients with colon polyps,2.9% were found to have SSAs.Most of the SSAs were located in the right side and were safely managed by colonoscopy. | Suryakanth R Gurudu Russell I Heigh Giovanni De Petris Evelyn G Heigh Jonathan A Leighton Shabana F Pasha Isaac B Malagon Ananya Das | 2010 | World Journal of Gastroenterology2010，16，27： | 7 |
| 2 | Phase Ⅲ,randomized,double-blind,placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant,advanced breast cancer (BOLERO-3)显示文摘 | O' Regan R Ozguroglu M Andre F Toi M Jerusalem G Wilks S Isaacs C Xu B Masuda N Arena FP Yardley D Yap YS Mukhopadhyay P Douma S El-Hashimy M Taran T Sahmoud T Lebwohl D Gianni L | | 0，，15： | 1 |
| 3 | Development of criteria for lamina emergent mechanism flexures with specific application to metals显示文摘 | Ferrell D B Isaac Yanal F | 2011 | Journal of Mechanical Design2011，133，3： | 1 |
| 4 | ACE polymor- phisms 显示文摘 | F A Sayed-Tabatabaei B A Oostra A Isaacs | 2006 | Circ Res2006，98，9： | 1 |
| 5 | Kahl,Synthesis of ether-and carbon-linked polycarboranyl porphyrindimers for cancer therapies显示文摘 | Meden F Isaac Stephen B | 2003 | Journal of Organometallic Chemistry2003，680，： | 1 |
| 6 | Adult degenerative scoliosis treated with XLIF: clinical and radiographical results of a prospective multicenter study with 24-month follow-up 显示文摘 | Phillips F M Isaacs R E Rodgers W B | 2013 | Spine (Phila Pa 1976)2013，38，21： | 1 |
| 7 | Development of criteria for lamina emergent mechanism flexures with specific application to metals 显示文摘 | FERRELL D B ISAAC YANAL F | 2011 | Journal of Mechanical Design2011，133，3： | 1 |
| 8 | Development of criteria for lamina emergent mechanism flexures with specific application to metals 显示文摘 | FERRELL D B ISAAC Y F MAGLEBY S P | 2011 | ASME Journal of Mechanical Design2011，133，3： | 1 |
| 9 | Development of criteria for lamina emergent mechanism flexures with specific application to metals显示文摘 | FERRELL D B ISAAC Y F MAGLEBY S P | 2011 | Journal of Mechanical Design2011，133，3： | 1 |
| 10 | Absence of Hinf I restriction abnormalities in renal oncocytoma mito- chondrial DNA显示文摘 | Brooks J D Marshall F F Isaacs W B | 1999 | Mool Urol1999，3，： | 1 |
| 11 | Synthesis of ether- and carbon-linked polycarboranyl porphyrindimers for cancer therapies显示文摘 | Isaac M F Kahl S B | 2003 | J Organomet Chem2003，680，： | 1 |
| 12 | Development ofcriteria for lamina emergent mechanism flexures with specificapplication to metals 显示文摘 | Ferrell D B Isaac Y F Magleby S P ^ al | 2011 | Journal of Mechanical Design2011，133，3： | 1 |
| 13 | The use of inhaled prostacyclin in nitropmsside-resistant pulmonary artery hypertension显示文摘 | Weston M W Isaac B F Crain C | 2001 | JHeart Lung Transplant2001，20，12： | 1 |
| 14 | The use of inhaled prostacyclin in nitroprusside-resistant pulmonary artery hypertension 显示文摘 | Weston M W Isaac B F Crain C | 2001 | J Heart Lung Transplant2001，20，12： | 1 |
| 15 | Precise manipulation of chromosomes in vivo enables genome-wide codon replacement 显示文摘 | Isaacs F J Carr P A Wang H H Lajoie M J Sterling B Kraal L Tolonen A C Gianoulis T A Goodman D B Reppas N B | 2011 | Science2011，333，6040： | 1 |
| 16 | Graft loss among renal-transplant recipients with early reduction of immunosuppression for BK viremia显示文摘AIM To review the incidence of graft loss and acute rejection among renal transplant recipients with early reduction of immunosuppression for BK viremia.METHODS We performed a retrospective analysis of consecutive de-novo kidney-only transplants from January 2009 to December 2012 to evaluate the incidence of Polyomavirus associated nephropathy(PyV AN). Recipient plasma was screened for BKV DNA via quantitative polymerase chain reaction(PCR) at months 1,3,6,9 and 12 post-transplant and on worsening graft function.Immunosuppression was reduced at ≥ 3-log copies/mL. Those with viremia of ≥ 4-log copies/mL(presumptive PyV AN) underwent renal transplant biopsy. Presumptive Py VAN(PP) and definitive Py VAN(DP; biopsy-proven) were treated by immunosuppression reduction(IR) only. RESULTS Among 319 kidney transplant recipients,the median age was 53 years(range 19-83),65.8% were male,and 58.9% were white. Biopsy-proven acute rejection was found in 18.5% within 0-168 wk. Death-censored graft loss occurred in 5.3%(n = 17) and graft loss attributable to PyV AN was 0.6%(n = 2). Forty-seven patients were diagnosed with PP(14.7%) and 18(5.6%) with DP. Graft loss among participants with PyV AN(8.5%) and those without(4.8%) was not significantly different. Deceased donor kidney transplantation(OR = 2.3,95%CI = 1.1-4.6) and AR(OR = 2.3,95%CI = 1.2-4.7) were associated with Py VAN in the multivariate analysis. BK viremia between 3 and 4-log copies/mL occurred in 27 patients,all of whom underwent IR. Of these,16(59%) never developed PyV AN while 11(41%) developed PyV AN(4 DP,7 PP) within a range of 11-39 wk. CONCLUSION Instituting an early reduction of immunosuppression,in the absence of adjunctive antivirals,is effective at preventing PyV AN and may be associated with a lower incidence of graft-loss without a reciprocal increase in the incidence of acute rejection. | Marwan M Azar Roland Assi Aziz K Valika David B Banach Isaac E Hall Marie-Louise Landry Maricar F Malinis | 2017 | World Journal of Transplantation2017，7，5： | 0 |
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