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| 1 | Management of pancreaticobiliary disease using a new intra-ductal endoscope:The Texas experience显示文摘AIM:To evaluate a new single-operator mini-endoscope, Spyglass,for its performance,feasibility and safety in the management of pancreaticobiliary disease. METHODS:In a multicenter retrospective analysis of patients undergoing intraductal endoscopy,we evaluated 128 patients(71 men,mean age 57.6 years).Indications were therapeutic(TX)in 72(56%) and diagnostic(DX)in 56(44%). RESULTS:Peroral endoscopy was performed in 121 and percutaneous in seven.TX indications included CBD stones in 41,PD stones in six,and biliary strictures in 25.DX indications included abnormal LFT’s in 15, abnormal imaging in 38 and cholangiocarcinoma staging in three.Visualization of the stone(s)was considered good in 31,fair in six,and poor in four. Advancement of the electrohydraulic lithotripsy probe was not possible in three patients and proper targeting of the lesion was partial in four patients.A holmium laser was used successfully in three patients.Ductal clearance was achieved in 37 patients after one procedure and in four patients after two procedures.Diagnosis of biliary strictures was modified in 20/29 and confirmed to be malignant in 10/23.Of the modified patients,no diagnosis was available in 17.Spyglass demonstrated malignancy in 8/17 and non-malignancy in nine.Suspected pathology by imaging studies and abnormal LFT’s was modified in 43/63(66%).Staging of cholangiocarcinoma demonstrated multicentric cholangiocarcinoma in 2/3.There was no morbidity associated with the use of Spyglass. CONCLUSION:Spyglass Spyscopeis a first generation, single operator miniature endoscope that can evaluate and treat various biliary and pancreatic tract diseases. | Douglas S Fishman Paul R Tarnasky Sandeep N Patel Isaac Raijman | 2009 | World Journal of Gastroenterology2009，15，11： | 22 |
| 2 | Improving doctor - patient communication in the outpatient setting using a facil- itation tool: a preliminary study 显示文摘 | Neeman N Isaac T Leveille S | 2012 | Int J Quality Health Care2012，24，4： | 1 |
| 3 | Crystal structure of an integral membrane light-harvesting complex from photosynthtic bacteria显示文摘 | McDermott G Prince S M Freer A A Hawthorthwaite-Lawless A M Papiz M Z Cogdell R J Isaacs N W | 1995 | Nature1995，374，6： | 1 |
| 4 | Effect of pressure on processes modelling the Maillard reaction显示文摘 | Isaacs N S Coulson M | 1996 | Journal of Physical Organic Chemistry1996，，9： | 1 |
| 5 | Hypergly- cemia: An independent marker of in-hospital mortality in patients with undiagnosed diabetes显示文摘 | Umpierrez G E Isaacs S D Bazargan N | 2002 | J Clin Endocrinol Metab2002，87，3： | 1 |
| 6 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 7 | The application of high pressure to some difficult wittig reactions 显示文摘 | ISAACS N S EL-DIN G N | 1987 | Tetrahedron Lett1987，28，19： | 1 |
| 8 | Phase Ⅲ,randomized,double-blind,placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant,advanced breast cancer (BOLERO-3)显示文摘 | O' Regan R Ozguroglu M Andre F Toi M Jerusalem G Wilks S Isaacs C Xu B Masuda N Arena FP Yardley D Yap YS Mukhopadhyay P Douma S El-Hashimy M Taran T Sahmoud T Lebwohl D Gianni L | | 0，，15： | 1 |
| 9 | Hyper- glycemia: an independent marker of in- hospital mortality in patients with undiagnosed diabetes显示文摘 | Umpierrez G E Isaacs S D Bazargan N | 2002 | J Clin Endocri- nol Metab2002，87，3： | 1 |
| 10 | The stereochemistry of high pressure aldehyde addition to allylstannanes显示文摘 | ISAACS N S MARSHALL R L YOUNG D J | 1992 | Tetrahedron Lett1992，33，： | 1 |
| 11 | The effect of high hydrostatic pressure on Salmonella thompson and Listeria monocytogenes examined by electron microscopy显示文摘 | Mackey B M Forestiere K Isaacs N S | 1994 | Letters in Applied Microbiology1994，19，： | 1 |
| 12 | The effects of high hydrostatic pressure on bacteria显示文摘 | Chilton P Isaacs N S Mackey B | 1997 | High Pressure Research in the Biosciences and Biotechnology1997，229，： | 1 |
| 13 | 显示文摘 | O' Sullivan B Verhaelen C | 1999 | Tetrahedron1999，55，11： | 1 |
| 14 | High strain-rate, small strain response of a NiTi shape-memory alloy显示文摘 | NASSER S N CHOI J Y GUO W G ISAACS J B | 2005 | Journal of Engineering Materials and Technology2005，127，： | 1 |
| 15 | Very high strain-rate response of a NiTi shape-memory alloy显示文摘 | NASSER S N CHIO J Y GUO W G ISAACS J B | 2005 | Mechanics of Materials2005，37，： | 1 |
| 16 | Endovenous la- ser treatment of the incompetent greater saphenous vein 显示文摘 | Min R J Zimmet S E Isaacs M N | 2001 | J Vase Interv Radio2001，12，10： | 1 |
| 17 | Weak Hopf Algebras Corresponding to Uq显示文摘 | Aizawa N Isaac P S | 2003 | J Math Phys2003，44，11： | 1 |
| 18 | Does arthroplasty type influence knee jointproprloception A longitudinal prospeetlve study comparing total and unicompartmental arthroplasty 显示文摘 | ISAAC S M BARKER K L DANIAL I N | 2007 | Knee2007，14，3： | 1 |
| 19 | Effect of highhydrostatic pressure on the volatile components of a glucose-lysinemodel system显示文摘 | HILL V M ISAACS N S LEDWARD D A | 1999 | Agri Food Chem1999，47，9： | 1 |
| 20 | Clear cell tumor of the lung: an immunohistochemical and ultrastructural study supporting a pericytic differentiation 显示文摘 | Lantuejoul S Isaac S Pinel N | 1997 | Mod Pathol1997，10，10： | 1 |
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