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| 1 | Successful treatment of psychosis induced by interferon alpha and ribavirin with paliperidone:first case reported显示文摘Several clinical studies have shown a large number of mental symptoms by immunomodulatory treatment with interferon (IFN). The most frequently described symptoms are depression, suicidal behaviour, manic symptoms, anxiety, psychosis and delirium, associated with other non-specific symptoms such as fatigue, irritability, psychomotor retardation, decreased libido, insomnia, difficulty in concentration and attention. Having a history of mental disorder contraindicates the use of IFN-alpha. These adverse effects that affect the mental state appear usually at the beginning of the treatment (most after 3 weeks of treatment). The incidence of psychotic episodes is low and the episodes usually remit when treatment is interrupted;only some cases require antipsychotic treatment. We present the case of a patient affected with hepatitis C who began to present self-referential delirious symptoms after receiving the treatment with IFN and who was successfully treated with paliperidone. This patient could be classified within the group of high-risk psychiatric patients given the family history of schizophrenia and his personal history of illegal drug consumption. The pharmacological actions of paliperidone are similar to other high potency atypical antipsychotics.丁he receptorbinding profile of paliperidone most closely resembles that of risperidone and ziprasidone. Paliperidone differs from risperidone and most other antipsychotics by its relatively low extent of enzymatic hepatic metabolism. To the best of our knowledge, this is the first case described that was successfully treated with paliperidone. | Carmen Maura Carrillo de Albornoz Calahorro Maria Isabel Navarrete Paez Margarita Guerrero Jimenez Luis Gutierrez Rojas | 2019 | General Psychiatry2019，32，4： | 2 |
| 2 | Transient elastography to rule out esophageal varices and portal hypertensive gastropathy in HIV-infected individuals with liver cirrhosis显示文摘 | Maria L. Montes Ramirez Jose F. Pascual-Pareja Matilde Sánchez-Conde Jose I. Bernardino De la Serna Francisco X. Zamora Vargas Pilar Miralles Juan M. Castro Margarita Ramírez Isabel Gutierrez Juan Gonzalez-García Juan Berenguer Jose R. Arribas López | 2012 | AIDS2012，，14： | 1 |
| 3 | Tourism agglomeration and its impact on social welfare: An empirical approach to the Spanish case 显示文摘 | Ainhoa Urtasun Isabel Gutierrez | 2006 | Tourism Management2006，27，4： | 1 |
| 4 | European and Mexican vs US diagnostic extracts of Bermuda grass and cat in skin testing显示文摘 | Désirée Larenas-Linnemann Alfredo Arias Cruz Isabel Rojo Gutierrez | 2011 | Annals of Allergy Asthma&Immunology2011，5，5： | 1 |
| 5 | Diabetes Mellitus in Older People: Position Statement on behalf of the International Association of Gerontology and Geriatrics (IAGG), the European Diabetes Working Party for Older People (EDWPOP), and the International Task Force of Experts in Diabetes显示文摘 | Alan Sinclair John E. Morley Leo Rodriguez-Ma?as Giuseppe Paolisso Tony Bayer Andrej Zeyfang Isabelle Bourdel-Marchasson Ulrich Vischer Jean Woo Ian Chapman Trisha Dunning Graydon Meneilly Joel Rodriguez-Saldana Luis Miguel Gutierrez Robledo Tali Cukierma | 2012 | Journal of the American Medical Directors Association2012，，6： | 1 |
| 6 | Evaluation of Grid Pattern Photocoagulation for Macular Edema in Central Vein Occlusion显示文摘 | John G. Clarkson Elaine Chuang Donald Gass Maria Pedroso Tony Cubillas Erlinda S. Duria Ditte J. Hess Isabel Rams Marguerite Ball Alex Gutierrez Nayla Muniz June Thompson Michele Pall Charles J. Pappas | 1995 | Ophthalmology1995，，10： | 1 |
| 7 | Thl and Th2 lymphocytes in perennialallergic rhinitis显示文摘 | Daniel Aguilar Angeles Ernestina Serrano Miranda Maria Isabel Rojo Gutierrez | 2006 | Rev Alerg Mex2006，53，3： | 1 |
| 8 | Qualitative Plasma PCR Assay (AMPLICOR CMV Test) versus pp65 Antigenemia Assay for Monitoring Cytomegalovirus Viremia and Guiding Preemptive Ganciclovir Therapy in Allogeneic Stem Cell Transplantation显示文摘 | Carlos Solano Isabel Munoz Antonio Gutierrez | 2001 | Journal of Clinical Microbiology2001，39，11： | 1 |
| 9 | Tourism agglomeration and itsimpacton social welfare:An empirical approach to the Spanish case 显示文摘 | Ainhoa Urtasun Isabel Gutierrez | 2006 | Tourism Management2006，27，： | 1 |
| 10 | Hotel location in tourism cities Madrid 1936-1998显示文摘 | Ainhoa Urtasun Isabel Gutierrez | 2006 | Annals of Tourism Research2006，，2： | 1 |
| 11 | Diabetes Mellitus in Older People: Position Statement on behalf of the International Association of Gerontology and Geriatrics (IAGG), the European Diabetes Working Party for Older People (EDWPOP), and the International Task Force of Experts in Diabetes显示文摘 | Alan Sinclair John E. Morley Leo Rodriguez-Ma?as Giuseppe Paolisso Tony Bayer Andrej Zeyfang Isabelle Bourdel-Marchasson Ulrich Vischer Jean Woo Ian Chapman Trisha Dunning Graydon Meneilly Joel Rodriguez-Saldana Luis Miguel Gutierrez Robledo Tali Cukierma | 2012 | Journal of the American Medical Directors Association2012，，6： | 1 |
| 12 | In vitro study of experimental factors affecting the microdialysis results 显示文摘 | Maria Santos Martinez Marttnez Beatriz Gutierrez Hurtado Clara- Isabel | 2002 | Analytica Chimica Acta2002，459，： | 1 |
| 13 | A direct test of the information content of the OECD growth forecasts 显示文摘 | Jef Vuchelen Maria Isabel Gutierrez | 2005 | International Journal of Forecasting2005，21，1： | 1 |
| 14 | Tourism agglomeration and its impact on social welfare:An empirical approach to the Spanish case显示文摘 | Ainhoa Urtasun Isabel Gutierrez | 2005 | Tourism Management2005，26，： | 1 |
| 15 | DNA methylation of multiple promoter-associated CpG islands in meningiomas: relationship with the allelic status at 1p and 22q显示文摘 | M. Josefa Bello Cinthia Ami?oso Isabel Lopez-Marin Dolores Arjona Pilar Gonzalez-Gomez M. Eva Alonso Jesus Lomas Jose M. Campos M. Elena Kusak Jesus Vaquero Alberto Isla Manuel Gutierrez Jose L. Sarasa Juan A. Rey | 2004 | Acta Neuropathologica2004，，5： | 1 |
| 16 | Phase Ⅱ trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A显示文摘Cyclin-dependent kinases 4 and 6(CDK4/6)inhibitors demonstrated activity in terms of progression-free survival(PFS)in advanced dedifferentiated liposarcoma(DD-LPS),a sarcoma with CDK4 amplification.CDK4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK inhibitors.Preclinical investigators of this study found that CDK4 overexpression,while not of CDKN2A,was the most consistent predictive factor for palbociclib efficacy in sarcomas.Advanced adult-type soft-tissue sarcoma,excluding DD-LPS,or bone sarcoma patients,progressing after at least one systemic line,whose tumors overexpressed CDK4,but not CDKN2A at baseline biopsy,were accrued in this single-arm phase II trial(EudraCT number:2016-004039-19).With the main endpoint of a 6-month PFS rate,40%was considered promising in this population.Palbociclib was administered orally at 125 mg/day for 21 days in 28-day cycles.A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening,archival material(141),and screening,baseline biopsy(95).There were 28(29%)with favorable mRNA profiles from 95 screened patients at baseline.From 23 enrolled patients,21 evaluable,the 6-month PFS rate was 29%(95%CI 9–48),and there were 6 patients out of 21 with a PFS longer than 6 months.The median PFS and overall survival were 4.2(95%CI 3.6–4.8)and 12(95%CI 8.7–15.4)months,respectively.Translational research showed a significant correlation between CDK4 mRNA and protein expression.Palbociclib was active in a variety of sarcoma subtypes,selected by CDK4/CDKN2A,and deserves further investigation in the sarcoma context. | Javier Martin-Broto Jeronimo Martinez-Garcia David SMoura Andres Redondo Antonio Gutierrez Antonio Lopez-Pousa Javier Martinez-Trufero Isabel Sevilla Roberto Diaz-Beveridge Maria Pilar Solis-Hernandez Amancio Carnero Marco Perez David Marcilla Jesus Garcia-Foncillas Pablo Romero Javier Fernandez-Jara Daniel Lopez-Lopez Ivan Arribas Nadia Hindi | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
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