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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Selective catalytic reduction (SCR) of NO by NH3 over TiO2-supported V2O5-WO3 and V2O5MoO3 catalysts显示文摘 | LUCA L ISABELLA N PIO F | 2000 | Topics in Catalysis2000，11，12： | 1 |
| 3 | Evaluation of procalcitonin for predicting septic muhiorgan failure and overall prognosis in secondary peritonitis 显示文摘 | Bettina MR Isabella F Markus W | 2007 | Arch Surg2007，142，2： | 1 |
| 4 | Efficacy of platelet gel in reconstructive bone surgery显示文摘 | Massimo F Paolo D Isabella F | 2005 | Orthopedics2005，28，2： | 1 |
| 5 | Phylogeography and evo- lutionary history of reassortant H9N2 viruses with potential hu- man health implications 显示文摘 | Alice F Isabella M Annalisa S | 2011 | Virology2011，85，： | 1 |
| 6 | Optimal Design of Survivable Mesh Networks Based on Line Switched WDM Self-healing Rings显示文摘 | Andrea F Isabella C Marco T | | 0，，03： | 1 |
| 7 | Base sequence determinants of amonafide stimulation of topoisomerase Ⅱ DNA cleavage 显示文摘 | DE ISABELLA P ZUNINO F CAPRANICO G | 1995 | Nucleic Acids Res1995，23，2： | 1 |
| 8 | Efficacy of platelet gel in reconstructive bone surgery显示文摘 | Massimo F Paolo D Isabella F | 2005 | Orthopedics2005，28，2： | 1 |
| 9 | SCR of NO by NH3 over TiO2-supported V2O5-MoO3 catalysts: Reactivity and redox behavior显示文摘 | LAURA C LUCA L ISABELLA N PIO F ALFONS B | 1999 | Appl Catal B: Environ1999，22，1： | 1 |
| 10 | Analysis of diterpenoic compounds in natural resins applied as bindersin museum objects by capillary electrophoresis 显示文摘 | Anna F Viliam K Isabella K | 2007 | Journal of Chromatography A2007，，1157： | 1 |
| 11 | Establishment and validation of an ELISA for the quantitation of HBsAg in recombinant hepatitis B vaccines显示文摘 | CATLA I C ISABELLA F D JALINE A C C | 2011 | Journal of Virological Methods2011，26，2： | 1 |
| 12 | Phylogeography and evo- lutionary history of reassortant H9N2 viruses with potential hu- man health implications显示文摘 | Alice F Isabella M Annalisa S | 2011 | J Virol2011，85，16： | 1 |
| 13 | Phylogeography and evolutionary history of reassortant H9N2 viruses with potential human health implications 显示文摘 | Alice F Isabella M Annalisa S | 2011 | J Virol2011，85，16： | 1 |
| 14 | Isopropenyl acetate,a remarkable,cheap and acylating agent of amines under solvent-and catalyst-free conditions:a systematic investigation显示文摘 | Romina P Isabella C Marta F | 2012 | Green Chem2012，14，： | 1 |
| 15 | Selective catalytic reduction(SCR) of NO by NH3 over TiO2-supported V2O5-WO3 and V2O5- MoO3 cata- lysts显示文摘 | LUCA L ISABELLA N PIO F | 2000 | Topics in Catalysis2000，11，12： | 1 |
| 16 | Frequency of dementia, depression, and other neuropsychiatric symptoms in 1,449 outpatients with Parkinson’s disease显示文摘 | Oliver Riedel Jens Klotsche Annika Spottke Günther Deuschl Hans F?rstl Fritz Henn Isabella Heuser Wolfgang Oertel Heinz Reichmann Peter Riederer Claudia Trenkwalder Richard Dodel Hans-Ulrich Wittchen | 2010 | Journal of Neurology2010，，7： | 1 |
| 17 | miR-155 gene:A typical multifunctional microRNA显示文摘 | Isabella F Francesca RA John C | 2009 | Biochimica et Biophysica Acta2009，1792，6： | 1 |
| 18 | Haemodynamic effects of acute intravenous metoprolol in apical ballooning syndrome with dy- amic left ventricular outflow tract obstruction 显示文摘 | Migliore F Bilato C Isabella G | 2010 | Eur J Heart Fail2010，12，3： | 1 |
| 19 | Reaction pathway of the reduction by CO under dry conditions of NOx species stored onto Pt-Ba/Al2O3 lean NOx trap catalysts显示文摘 | PIO F LUCA L ISABELLA N | 2010 | Journal of Catalysis2010，274，2： | 1 |
| 20 | Expression of celt cycle pro- teins in male breast carcinoma显示文摘 | Rani K Isabella F Theresa R | 2010 | World J Surg Oncol2010，12，8： | 1 |
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