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2篇 您的检索式：作者名="Isao Narama"

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		题名	作者	年代	出处	被引量
	1	Diabetes enhances dental caries and apical periodontitis in caries-susceptible wbn/ko- bslc rats显示文摘	Yasushi Kodama Isao Narama	2011	Comp Med2011，61，1：	1
	2	The Anatomic Pathology Evaluation of Liver with Diethylinitrosamine Treated via Intraperitoneal Injection Singly and Peros for 90 Days Carcinogenicity Study in F344 Rats显示文摘Objective:To establish the integrity experiment method of short(medium)-term carcinogenicity test pursuant to GLP,make into relative SOP and improve the safeguard in the center.Methods:Diethylinitrosamine(DEN) is known as carcinogenic agent,whose target organ is liver. Using the two-stage carcinogenesis test method,DEN was treated to F344 rats via intraperitoneal injection singly(200 mg/kg),and peros administrated for 90 days(10 ppm). The liver in any group rat will be examined by light microscopy.Results:In pathologic examination,no liver cell tumor was shown in the livers of the rats that were singly treated with a carcinogenic chemical-DEN.Foci of cellular alteration were observed in the livers of these rats. The proliferation lesions of liver from slight to seveity(foci of cellular alteration-hepatocelluar adenoma-hepatocellular carcinoma)were observed in the livers of the rats which exposed peros to a low dose of DEN for 90 days after initiation by a single intraperitoneal injection. The incidence of hepatocelluar tumor was 35% in male animal,which was not shown in the liver of female rat.Conclusion:For current results,it may be possible that low-dose DEN acts as a promotor of hepatocelluar tumor if it was exposed in a population for a long time. It is considered that male hormone has a synergistic effect on hepatocelluar tumor development of DEN. This two-stage carcinogenesis test might be a new model for the study of drug induced and promoted carcinogenesis,which could be used to evaluate the carcinogenesis of chemical compound fast.	LI Shan-shan ZHANG Lin LI Bao-wen LANG Shu-hui YANG Yan-wei ZHANG Di ZHANG Yang NARAMA Isao KAWAYI Zeshow KANEKO Toyozo XING Rui-chang WANG Xiu-wen LI Bo	2008	Chinese Journal of Biomedical Engineering(English Edition)2008，17，2：	0

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