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| 1 | A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley显示文摘瞄准:为了系统地检验风险因素的关联的程度,例如年龄,与原因的体的 Tp53 分子损害消费了饮食的习惯和家庭倾向在北印度的 Kashmiri 人口之中提高食道的有鳞的房间癌(ESCC ) 的致癌作用严厉。方法:所有情况(n = 51 ) 并且控制(n = 150 ) 是克什米尔山谷的永久居民。基因改变在 Tp53 肿瘤的前 ons 5-8 被决定压制或在 45 个 ESCC 盒子之中的基因组织学地由 PCR-SSCP 分析证实了。为单个癌症盒子的数据(n = 45 ) 并且住院病人控制(n = 150 ) 与非癌症,疾病在癌症的家庭历史上包括了信息,与病人的年龄组一起的三十个占优势的普通饮食的风险因素。在到从这些参数的万物有灵论的数据的 p53 前 ons 的基因损害的关联被 Chi 平方测试与健康控制一起产生到所有 45 个组织学地证实的 ESCC 盒子。结果:(77.8%) 45 中的 35 个组织学地描绘了与 45 正常样品中的 1 个对比的有的类似的体细胞突变从一样的耐心的显示出的细菌线变化从邻近的区域获得了的肿瘤样品。 SSCP 分析表明了改变在 6 上在前被发现的那很普通的 p53 基因(77.7%),那没与个人和 clinicopathological 参数的年龄相关,但是与癌症的家庭历史显示出重要词语索引( P<0.05 )( CD = 58 ),在消费的一个未知地点,和饮食的习惯建议细菌线倾向局部地种芥属蔬菜“ Hakh ”( CD = 19.5 ),红 chillies ( CD = 20.2 ),热咸苏打茶( CD = 2.37 )并且本地烤的面包( CD = 1.1 )。结论:我们的学习建议那体的染色体变化特别在 6 Tp53 基因上的前,在人种上的食道的癌症病人之中,克什米尔山谷的同质的人口是仔细与到各种各样的普通饮食的风险因素,特别热的咸茶,肉,烤的面包和“ Hakh ”的继续的暴露有关,那富于 nitrosoamines 和家庭癌症历史。 | Imtiyaz Murtaza Dhuha Mushtaq Mushtaq A Margoob Amit Dutt Nisar Ahmad Wani Ishfaq Ahmad Mohan Lal Bhat | 2006 | World Journal of Gastroenterology2006，12，25： | 8 |
| 2 | 柏芩提取液的药效学及对奶牛子宫内膜炎的疗效评价显示文摘柏芩提取液是由黄柏、黄芩、红花、党参等组成,为了探讨其对奶牛子宫内膜炎的治疗作用,采用实验性家兔子宫内膜炎模型进行柏芩提取液的主要药效学研究。确定药效作用后,按照农业农村部颁布的《防治奶牛临床子宫内膜炎的抗微生物兽药的靶动物安全性和有效性试验指导原则》对其进行奶牛子宫内膜炎的临床疗效评价。药效学试验结果表明,与模型组比较,柏芩提取液能明显改善实验性子宫内膜炎家兔的临床症状,血液白细胞计数分类、子宫分泌物涂片镜检、尿液及子宫分泌物化学检查结果趋于正常,并且能够减轻子宫充血、炎性细胞浸润、上皮细胞脱落等组织病理学改变。临床疗效试验结果表明,给药后第10天,柏芩提取液高、中剂量组的治愈率极显著高于低剂量组(P<0.01),且与阳性药物对照组无显著差异(P>0.05);各试验组的总有效率差异均不显著(P>0.05)。给药后第21天,柏芩提取液高、中剂量组的治愈率显著高于低剂量组(P<0.05),且与阳性药物对照组差异不显著(P>0.05);各试验组的总有效率未见明显差异(P>0.05)。以上结果证明柏芩提取液对实验性家兔子宫内膜炎和临床奶牛子宫内膜炎具有良好的治疗作用,其中1.5和1.0 g/mL浓度(30 mL/次)对临床病例的治疗效果明显,与土霉素效果相似,0.5 g/mL浓度效果不明显。本研究为其进一步研究和开发应用奠定了基础。 | 钱峰 苗钰松 MUHAMMAD Ishfaq 尹鹏 尹建丽 李继昌 | 2020 | 中国畜牧兽医2020，47，5： | 6 |
| 3 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 4 | 黄曲霉毒素B_1诱导的AA肉鸡亚慢性肝损伤模型的建立与评价显示文摘72只AA肉鸡适应性饲养3d后随机分为4组,分别为空白对照组(不合黄曲霉毒素B1(AFB1)的空白饲料)、AFB1低剂量组(饲料中含1mg/kgAFB1)、AFB1中剂量组(饲料中含3mg/kgAFB1)、AFB1高剂量组(饲料中含5mg/kgAFB1)。结果表明,连续饲喂高剂量AFB128d时,AA肉鸡肝体指数显著高于对照组(P〈0.05);血清酶学指标谷丙转氨酶(ALT)、谷草转氨酶(AST)活性极显著高于对照组(P〈0.01),碱性磷酸酶(ALP)活性显著高于对照组(P〈0.05);肝脏总超氧化物岐化酶(T—SOD)和谷胱甘肽过氧化物酶(GSH—Px)活性极显著低于对照组(P〈0.01),丙二醛(MDA)含量极显著高于对照组(P〈0.01)。病理切片结果显示,在28dAFB1高剂量组肉鸡肝脏发生严重病变。平均日增重结果表明,在14~21d,AFB1中、高剂量组AA肉鸡均极显著低于对照组(P〈0.01);21.28d,高剂量组平均日增重极显著低于对照组(P〈0.01),中剂量组平均日增重显著低于对照组(P〈0.05)。综上所述,连续饲喂含有5mg/kgAFB1的饲料28d可以成功建立肉鸡亚慢性肝损伤模型,饲料中污染AFB1能严重影响AA肉鸡增重。 | 孙晓琦 崔晓旭 李伟 韩美玉 Ishfaq Muhammad 王鹤 程平 张秀英 | 2016 | 中国家禽2016，38，24： | 3 |
| 5 | Growth,yield and water productivity of dry direct seeded rice and transplanted aromatic rice under different irrigation management regimes显示文摘Sustainability of traditionally cultivated rice in the rice-wheat cropping zone(RWCZ)of Pakistan is dwindling due to the high cost of production,declining water resources and escalating labour availability.Thus,farmers and researchers are compelled to find promising alternatives to traditional transplanted rice(TPR).A field study was conducted in Punjab,Pakistan,in 2017 and 2018 to explore the trade-offs between water saving and paddy yield,water productivity and economics of two aromatic rice varieties under dry direct seeded rice(DDSR)and TPR.The experiment was comprised of three irrigation regimes on the basis of soil moisture tension(SMT)viz.,continuous flooded(>–10 kPa SMT),alternate wetting and drying(AWD)(–20 kPa SMT)and aerobic rice(–40 kPa SMT),maintained under TPR and DDSR systems.Two aromatic rice verities:Basmati-515 and Chenab Basmati-2016 were used during both years of study.In both years,DDSR produced higher yields(13–18%)and reduced the total water inputs(8–12%)in comparison to TPR.In comparison to traditional continuous flooded(CF),AWD under DDSR reduced total water input by 27–29%and improved the leaf area index(LAI),tillering,yield(7–9%),and water productivity(44–50%).The performance of AWD with regard to water savings and increased productivity was much higher in DDSR system as compared to AWD in TPR system.Cultivation of DDSR with aerobic irrigation improved water savings(49–55%)and water productivity(22–30%)at the expense of paddy yield reduction(36–39%)and spikelet sterility.With regard to variety,the highest paddy yield(6.6 and 6.7 t ha–1)was recorded in DDSR using Chenab Basmati-2016 under AWD irrigation threshold that attributed to high tiller density and LAI.The economic analysis showed DDSR as more beneficial rice establishment method than TPR with a high benefit-cost ratio(BCR)when the crop was irrigated with AWD irrigation threshold.Our results highlighted that with the use of short duration varieties,DDSR cultivation in conjunction with AWD irrigation can be more beneficial for higher productivity and crop yield. | Muhammad Ishfaq Nadeem Akbar Shakeel Ahmed Anjum Muhammad Anwar-Ul-haq | 2020 | Journal of Integrative Agriculture2020，19，11： | 2 |
| 6 | 抗鸡毒支原体与大肠埃希氏菌混合感染中药复方配比的优化显示文摘建立混合感染鸡的模型,再用筛选出的中药组合物,包括板蓝根、连翘、桑白皮、银杏叶、甘草和丹参6味中药,用于治疗混合感染鸡以寻求最佳配比。利用均匀试验六因素十水平的设计方法(U^(*)_(10)(10^(6)))制备复方水提物,对10个组别的感染鸡进行灌服治疗。采用多指标评估方法,分别以体外试验中鸡毒支原体和大肠埃希氏菌的最小抑菌浓度、体内试验中气囊和气管病变程度这4个指标进行评估。再用最小-最大归一化方法对4个指标的得分进行归一化处理,并赋予它们相同比例的权重以计算总得分。最后以总分为指标,利用数据处理系统(data processing system, DPS)建立了多元非线性回归方程。经以上数据分析,发现板蓝根、连翘、银杏叶、桑白皮、甘草和丹参的最优剂量比例为14:7:11:12:5:3。 | 吴志勇 范倩倩 包佳鑫 李睿 Muhammad Ishfaq 李继昌 | 2021 | 动物医学进展2021，42，3： | 2 |
| 7 | Motion estimation for content adaptive video compression 显示文摘 | Luo Jiancong Ahmad Ishfaq Liang Yongfang | 2008 | IEEE Trans on Circuits and Systems for Video Technology2008，18，7： | 1 |
| 8 | Hub location–allocation in intermodal logistic networks显示文摘 | Rafay Ishfaq Charles R. Sox | 2010 | European Journal of Operational Research2010，，2： | 1 |
| 9 | Design of intermodal networks with hub delays显示文摘 | Ishfaq R Sox C R | 2012 | European Journal of Operational Research2012，220，3： | 1 |
| 10 | Modified Harris Hawks Optimization Based Test Case Prioritization for Software Testing显示文摘Generally,software testing is considered as a proficient technique to achieve improvement in quality and reliability of the software.But,the quality of test cases has a considerable influence on fault revealing capability of software testing activity.Test Case Prioritization(TCP)remains a challenging issue since prioritizing test cases is unsatisfactory in terms of Average Percentage of Faults Detected(APFD)and time spent upon execution results.TCP ismainly intended to design a collection of test cases that can accomplish early optimization using preferred characteristics.The studies conducted earlier focused on prioritizing the available test cases in accelerating fault detection rate during software testing.In this aspect,the current study designs aModified Harris Hawks Optimization based TCP(MHHO-TCP)technique for software testing.The aim of the proposed MHHO-TCP technique is to maximize APFD and minimize the overall execution time.In addition,MHHO algorithm is designed to boost the exploration and exploitation abilities of conventional HHO algorithm.In order to validate the enhanced efficiency of MHHO-TCP technique,a wide range of simulations was conducted on different benchmark programs and the results were examined under several aspects.The experimental outcomes highlight the improved efficiency of MHHO-TCP technique over recent approaches under different measures. | Manar Ahmed Hamza Abdelzahir Abdelmaboud Souad Larabi-Marie-Sainte Haya Mesfer Alshahrani Mesfer Al Duhayyim Hamza Awad Ibrahim Mohammed Rizwanullah Ishfaq Yaseen | 2022 | Computers, Materials & Continua2022，，7： | 1 |
| 11 | Static Scheduling Algorithms for Allocating Directed Task Graphs to Multiprocessors 显示文摘 | K Yu-Kwong A Ishfaq | 1999 | ACM Computing Surveys1999，31，4： | 1 |
| 12 | Multi-view video: get ready for next-generation television 显示文摘 | ISHFAQ A | 2007 | IEEE Distributed Systems Online2007，8，3： | 1 |
| 13 | On multiprocessor task scheduling using efficient state space search approaches 显示文摘 | Kwok Yu-Kwong Ahmad Ishfaq | 2005 | Journal of Parallel and Distributed Computing2005，65，12： | 1 |
| 14 | Multi-view video: get ready for next-generation television显示文摘 | Ishfaq A | 2007 | IEEE Distributed Systems Online2007，8，3： | 1 |
| 15 | Credit worthiness of rural borrowers of Pakistan显示文摘 | Chaudhary M Ishfaq M | | 0，，： | 1 |
| 16 | Static Scheduling Algorithms for Allocating Directed Task Graphs to Multiprocessors 显示文摘 | Yu-Kwong Kwok Ishfaq Ahmad | 1999 | ACM Computing Surveys1999，31，4： | 1 |
| 17 | Efficient Scheduling of Arbitrary Task Graphs to Multiprocessors Using a Parallel Genetic Algorithm显示文摘 | Yu-Kwong Kwok Ishfaq Ahmad | 1997 | Journal of Parallel and Distributed Computing1997，，1： | 1 |
| 18 | Multi-view Video: Get Ready for Next-generation Television显示文摘 | Ishfaq A | 2007 | IEEE Distributed Systems Online2007，8，3： | 1 |
| 19 | Active caching of On-Line-Analytical-Processing queries in WWW proxies显示文摘 | Thanasis Loukopoulos Panos Kalnis Ishfaq Ahmad Dimitris Papadias | 2001 | IEEE Computer Society2001，01，93918： | 1 |
| 20 | Intermodal logistics: The interplay of financial, op- erational and service issues显示文摘 | Ishfaq R Sox C R | 2010 | Transportation Research Part E: Logis- tics and Transportation Review2010，46，6： | 1 |
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