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| 1 | Deep-learning classifier with ultrawide-field fundus ophthalmoscopy for detecting branch retinal vein occlusion显示文摘AIM: To investigate and compare the efficacy of two machine-learning technologies with deep-learning(DL) and support vector machine(SVM) for the detection of branch retinal vein occlusion(BRVO) using ultrawide-field fundus images. METHODS: This study included 237 images from 236 patients with BRVO with a mean±standard deviation of age 66.3±10.6 y and 229 images from 176 non-BRVO healthy subjects with a mean age of 64.9±9.4 y. Training was conducted using a deep convolutional neural network using ultrawide-field fundus images to construct the DL model. The sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and area under the curve(AUC) were calculated to compare the diagnostic abilities of the DL and SVM models. RESULTS: For the DL model, the sensitivity, specificity, PPV, NPV and AUC for diagnosing BRVO was 94.0%(95%CI: 93.8%-98.8%), 97.0%(95%CI: 89.7%-96.4%), 96.5%(95%CI: 94.3%-98.7%), 93.2%(95%CI: 90.5%-96.0%) and 0.976(95%CI: 0.960-0.993), respectively. In contrast, for the SVM model, these values were 80.5%(95%CI: 77.8%-87.9%), 84.3%(95%CI: 75.8%-86.1%), 83.5%(95%CI: 78.4%-88.6%), 75.2%(95%CI: 72.1%-78.3%) and 0.857(95%CI: 0.811-0.903), respectively. The DL model outperformed the SVM model in all the aforementioned parameters(P<0.001). CONCLUSION: These results indicate that the combination of the DL model and ultrawide-field fundus ophthalmoscopy may distinguish between healthy and BRVO eyes with a high level of accuracy. The proposed combination may be used for automatically diagnosing BRVO in patients residing in remote areas lacking access to an ophthalmic medical center. | Daisuke Nagasato Hitoshi Tabuchi Hideharu Ohsugi Hiroki Masumoto Hiroki Enno Naofumi Ishitobi Tomoaki Sonobe Masahiro Kameoka Masanori Niki Yoshinori Mitamura | 2019 | International Journal of Ophthalmology(English edition)2019，12，1： | 16 |
| 2 | Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH显示文摘 | Yuki Kimura Hideyuki Hyogo Sho-ichi Yamagishi Masayoshi Takeuchi Tomokazu Ishitobi Yoshitaka Nabeshima Koji Arihiro Kazuaki Chayama | 2010 | Journal of Gastroenterology2010，，7： | 3 |
| 3 | Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia显示文摘 | Hideyuki Hyogo Susumu Tazuma Koji Arihiro Keiko Iwamoto Yoshitaka Nabeshima Motoki Inoue Tomokazu Ishitobi Michihiro Nonaka Kazuaki Chayama | 2008 | Metabolism2008，，12： | 2 |
| 4 | Efluxes of dissolved organic phosphorus (DOP) and phosphate from the sediment to the overlying water at high temperature and low dissolved oxygen concentration conditions in an eutrophic brackish lake 显示文摘 | Kamiya H Ishitobi | 2001 | Japanese Journal of Limnology2001，62，1： | 1 |
| 5 | Prognostic significance of neutropenia On day one of anthracycline-based neoadjuvant chemotherapy in operable breast cancer显示文摘 | Ishitobi M Komoike Y Mommura K | 2010 | Oncology2010，78，34： | 1 |
| 6 | Nonlinear adap- tive model following control for a 3-DOF tandem rotor model helicopter 显示文摘 | Ishitobi M Nishi M Nakasaki K | 2010 | Control Engineering Practice2010，3，： | 1 |
| 7 | Retrospective Analysis of Concurrent vs Sequential Administration of Radiotherapy and Hormone Therapy Using Aromatase Inhibitor for Hormone Receptor- positive Postmenopausal Breast Cancer 显示文摘 | Makoto Ishitobi Yoshifumi Komoike | 2009 | Anticancer Research2009，29，： | 1 |
| 8 | Stability of zeros of sampled system with fractional order hold显示文摘 | ISHITOBI M | 1996 | IEE Proceedings-Control Theory and Applications1996，143，2： | 1 |
| 9 | Chaos and bifurcations in a nonlinear vehicle model 显示文摘 | ZHU Q ISHITOBI M | 2004 | Journal of Sound and Vibration2004，275，345： | 1 |
| 10 | Hypomanic switching during influenza infection without intracranial infection in an adolescent patient with bipolar disorder显示文摘 | Ishitobi M Shukunami K Murata T | 2011 | Pediatr Emerg Care2011，27，7： | 1 |
| 11 | Codeand Data Placement for Embedded Processors with Scratehpad and Cache Memories 显示文摘 | YURIKO Ishitobi TOHRU Ishihara HIROTO Yasuura | 2010 | Journal of Signal Processing Systems2010，6，2： | 1 |
| 12 | Stability of zeros of discrete-time multivariable with GSHF显示文摘 | LIANG S XIAN X D ISHITOBI M | 2010 | International Journal of Innovative Computing Information and Control2010，6，7： | 1 |
| 13 | Association of CRHR1and CRHR2with major depressive disorder and panic disorder in a Japanese population显示文摘 | Ishitobi Y Nakayama S Yamaguchi K | 2012 | Am J Med Genet B Neuropsychiatr Genet2012，159，4： | 1 |
| 14 | Distinguishing between autism spectrum disorder and attention deficit hyperactivity disorder by using behavioral checklists, cognitive assessments, and neuropsychological test battery显示文摘 | Matsuura N Ishitobi M Aral S | 2014 | Asian J Psychiatr2014，12，： | 1 |
| 15 | Hypomanic switc- hing during influenza infection without intracranial infection in an adolescent patient with bipolar disorder 显示文摘 | Ishitobi M Shukunami K Murata T | 2011 | Pediatr Emerg Care2011，27，7： | 1 |
| 16 | Salivary alpha-amylase and cortisol re- sponsiveness following electrical stimulation stress in panic disorder patients 显示文摘 | Tanaka Y Ishitobi Y Maruyama Y Kawano A An- do T Imanaga J Okamoto S Kanehisa H Higuma H Ninomiya T Tsuru J Hanada H Isogawa K Akiyoshi J | 2012 | NeurosciRes2012，73，2： | 1 |
| 17 | Development of Alumi- num Hood Structure for Pedestrian Protection显示文摘 | Koki Ikeda Hideki Ishitobi | 2003 | AE Paper2003，，1： | 1 |
| 18 | Breast cancer subtype and distant recurrence after ipsilateral breast tumor recurrence显示文摘 | Ishitobi M Okumura Y Arima N | 2013 | Ann Surg Oncol2013，20，6： | 1 |
| 19 | Subhypnotic doses of propofol accelerate extinction of conditioned taste aversion显示文摘 | Ishitobi S Miyamoto T Oi K | 2003 | Behav Brain Res2003，141，2： | 1 |
| 20 | Mesenchymal- stem-cell-derived exosomes accelerate skeletal muscle regen- eration显示文摘 | Nakamura Y Miyaki S Ishitobi H | 2015 | FEBS Lett2015，589，11： | 1 |
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