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| 1 | Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy. | Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，44： | 5 |
| 2 | Expression of CD55 and CD59 on peripheral blood cells in patients with lymphoproliferative disease of granular lymphocytes显示文摘 | Isoda A Tsukamoto N Mitsui T | 2007 | Int J Lab Hematol2007，29，1： | 1 |
| 3 | Expression of CD55 and CD59 on peripheral blood cells in patients with lymphoproliferative disease of granular lymphocytes显示文摘 | Tsukamoto N Mitsui T | 2007 | Int J Lab Hematol2007，29，1： | 1 |
| 4 | Pathogenicity of a highly pathogenic avian influenza virus,A/chicken/Yamaguchi/7/04(H5N1)in different species of birds and mammals显示文摘 | Sakoda Y Kishida N | 2006 | Arch Virol2006，151，7： | 1 |
| 5 | Pathogenicity of H5 influenza viruses for ducks显示文摘 | Sakoda Y Isoda N | 2005 | Arch Virol2005，150，7： | 1 |
| 6 | A novel method of endoscopic mucosal resection using sodium hyaluronate 显示文摘 | Yamamoto H Yube T Isoda N | 1999 | Gastrointest Endosc1999，50，2： | 1 |
| 7 | Hepatoprotective effect of vitamin B12 on dimethylnitrosamine-induced liver injury 显示文摘 | Isoda K Kagaya N Akamatsu S | 2008 | Biol Pharm Bull2008，31，2： | 1 |
| 8 | Long-term outcomes for patients with solitary hepatocellular carcinoma treated by laparoscopic microwave coagulation 显示文摘 | Kawamoto C Ido K Isoda N | 2005 | Cancer2005，103，5： | 1 |
| 9 | Clinical efficacy of superfine dispersed lentinan (beta-1,3-glucan) in patients with hepatocellular carcinoma显示文摘 | ISODA N EGUCHI Y NUKAYA H | 2009 | Hepatogastroenterology2009，56，： | 1 |
| 10 | Expressions of galectin- 3, glutathione S-transferase A2 and peroxiredoxin-1 by nonylphenol-incubated Caco-2 cells and reduction in transepithelial electrical resistance by nonylphenol显示文摘 | Isoda H Talorete T P N Han J | 2006 | Toxicology in Vitro2006，20，： | 1 |
| 11 | Lack of interleukin - 1 receptor antagonist modulates plaque composition in apolipopro- tein E - deficient mice显示文摘 | ISODA K SAWADA S ISHIGAMI N | 2004 | Arterioseler Thromb Vase Biol2004，24，6： | 1 |
| 12 | Expression of CD55 and CD59 on peripheral blood cells in patients with tymphoproliferative disease of granular lymphocytes 显示文摘 | Isoda A Tsukamoto N Mitsui T | 2007 | lnt J Lab Hematol2007，29，1： | 1 |
| 13 | Catalytic activities of NiMo and CoMo/A1203 of variable Ni and Co contents for the hydrodesulfurization of 4,6-dimethyldibenzothiophene in the presence of naphthalene显示文摘 | Isoda T Shinichi N Ma X | 1997 | Applied Catalysis A: General1997，150，1： | 1 |
| 14 | Infection of a Japanese patient by genotype 4 hepatitis E virus while traveling in Vietnam显示文摘 | Koizumi Y Isoda N Sato Y | 2004 | J Clin Microbiol2004，42，： | 1 |
| 15 | Research and development programs on timber structures in Japan显示文摘 | ISODA H OKADA H KAWAI N | 2002 | NISP Special Publication SP2002，2，3： | 1 |
| 16 | Arteriovenous malformation of the brain:histological study and micrometric measurement of abnormal vessels显示文摘 | Isoda K Fukuda H Takamura N | 1981 | Acta Pathol Jpn1981，31，： | 1 |
| 17 | Arteriovenous malformation of the brain:histological study and micrometric measurement of abnormal vessels显示文摘 | Isoda K Fukuda H Takamura N | 1981 | Acta Pathol Jpn1981，31，5： | 1 |
| 18 | A novel method of endoscopic mucosal resection using sodium hyaluronate 显示文摘 | Yamaraoto H Yube T Isoda N | 1999 | Gastrointest Endosc1999，50，2： | 1 |
| 19 | Prognosis of small hepatocellular carcinoma after laparoscopic ethanol injection显示文摘 | Kawamoto C Ido K Isoda N | 1999 | Gastrolntest Endosc1999，50，2： | 1 |
| 20 | Arteriovenous malformation of the brain:histological study and micrometric measurement of abnormal vessels显示文摘 | Isoda K Fukuda H Takamura N | | 0，，： | 1 |
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