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| 1 | Prospective study of differential diagnosis of hepatic tumors by pattern-based classification of contrast-enhanced sonography显示文摘AIM: To prospectively evaluate the usefulness of a pattern-based classification of contrast-enhanced sonographic findings for differential diagnosis of hepatic tumors. METHODS: We evaluated the enhancement pattern of the contrast-enhanced sonography images in 586 patients with 586 hepatic lesions, consisting of 383 hepatocellular carcinomas, 89 metastases, and 114 hemangiomas. After injecting a galactose-palmitic acid contrast agent, lesions were scanned by contrast- enhanced harmonic gray-scale sonography in three phases: arterial, portal, and late. The enhancement patterns of the initial 303 lesions were classified retrospectively, and multiple logistic regression analysis was used to identify enhancement patterns that allowed differentiation between hepatic tumors. We then used the pattern-based classification of enhancement we had retrospectively devised to prospectively diagnose 283 liver tumors. RESULTS: Seven enhancement patterns were found to be significant predictors of different hepatic tumors. The presence of homogeneous or heterogeneous enhancement both in the arterial and portal phase was the typical enhancement pattern for hepatocellular carcinoma, while the presence of peritumoral vessels in the arterial phase and ring enhancement or a perfusion defect in the portal phase was the typical enhancement pattern for metastases, and the presence of peripheral nodular enhancement both in the arterial and portal phase was the typical enhancement pattern forhemangioma. The sensitivity, specificity, and accuracy of prospective diagnosis based on the combinations of enhancement patterns, respectively, were 93.2%, 96.2%, and 94.0% for hepatocellular carcinoma, 87.9%, 99.6%, and 98.2% for metastasis, and 95.6%, 94.1%, and 94.3% for hemangioma. CONCLUSION: The pattern-based classification of the contrast-enhanced sonographic findings is useful for differentiating among hepatic tumors. | Kazushi Numata Tetsuo Isozaki Manabu Morimoto Kazuya Sugimori Reiko Kunisaki Toshio Morizane Katsuaki Tanaka | 2006 | World Journal of Gastroenterology2006，12，39： | 18 |
| 2 | Lansoprazole ameliorates intestinal mucosal damage induced by ischemia-reperfusion in rats显示文摘AIM: To investigate the protective effect of lansoprazoleon ischemia and reperfusion (I/R)-induced rat intestinalmucosal injury in vivo.METHODS: Intestinal damage was induced by clampingboth the superior mesenteric artery and the celiac trunkfor 30 rain followed by reperfusion in male Sprague-Dawleyrats. lansoprazole was given to rats intraperitoneally 1 hbefore vascular clamping.RESULTS: Both the intraluminal hemoglobin and proteinlevels, as indices of mucosal damage, significantlyincreased in I/R-groups comparion with those of sham-operation groups. These increases in intraluminal hemoglobinand protein levels were significantly inhibited by the treatmentwith lansoprazole at a dose of 1 mg/kg. Small intestineexposed to I/R resulted in mucosal inflammation that wascharacterized by significant increases in thiobarbituric acid-reactive substances (TBARS), tissue-associatedmyeloperoxidase activity (MPO), and mucosal content of ratcytokine-induced neutrophil chemoattractant-1 (CINC-1).These increases in TBARS, MPO activities and CINC-1 contentin the intestinal mucosa after I/R were all inhibited bypretreatment with lansoprazole at a dose of 1 mg/kg.Furthermore, the CINC-1 mRNA expression was increasedduring intestinal I/R, and this increase in mRNA expressionwas inhibited by treatment with lansoprazole.CONCLUSION: Lansoprazole inhibits lipid peroxidation andreduces development of intestinal mucosal inflammationinduced by I/R in rats, suggesting that lansoprazole mayhave a therapeutic potential for I/R injury. | Hiroshi Ichikawa Norimasa Yoshida Tomohisa Takagi Naoya Tomatsuri Kazuhiro Katada Yutaka Isozaki Kazuhiko Uchiyama Yuji Naito Takeshi Okanoue Toshikazu Yoshikawa | 2004 | World Journal of Gastroenterology2004，10，19： | 10 |
| 3 | A visible light-driven plasmonic photocatalyst显示文摘We demonstrate a bottom-up approach to fabricating a visible light-driven titania photocatalyst device bearing an embeddedtwo-dimensional (2D) array of gold nanoparticles (AuNPs) as a near-field light-generating layer. The device is a layered structureprepared by depositing a 2D array of AuNPs on a transparent conductive substrate (10 nm indium tin oxide (ITO) layer on quartz),coating the 2D array of AuNPs with a monolayer of trimethoxyoctylsilane (TMOS), and depositing titania nanocrystals on the anchoringmolecule (TMOS) layer. The visible light activity of the device was tested using photocatalytic degradation of methylene blue (MB) byilluminating the device with visible light (700 nm light) and ultraviolet (UV) light (250–380 nm). The localized surface plasmonresonance peak of the 36 nm AuNP 2D array is around 700 nm with a full-width at half-maximum of 350 nm. In comparison with othercontrol samples, the device showed the highest photocatalytic activity with visible irradiation, which was 1.7 times higher than that oftitania with UV irradiation. The origin of the visible light activity was confirmed by both quadratic incident light power dependency andaction spectrum to be plasmon-induced (near-field enhancement by AuNPs) two-photon absorption. | Francesca Pincella Katsuhiro Isozaki Kazushi Miki | 2014 | Light(Science & Applications)2014，3，1： | 7 |
| 4 | Secular change in lifetime of granitic crust and the continental growth: A new view from detrital zircon ages of sandstones显示文摘U-Pb ages of detrital zircons were newly dated for 4 Archean sandstones from the Pilbara craton in Australia, Wyoming craton in North America, and Kaapvaal craton in Africa. By using the present results with previously published data, we compiled the age spectra of detrital zircons for 2.9, 2.6, 2.3,1.0, and0.6 Ga sandstones and modern river sands in order to document the secular change in age structure of continental crusts through time. The results demonstrated the following episodes in the history of continental crust:(1) low growth rate of the continents due to the short cycle in production/destruction of granitic crust during the Neoarchean to Paleoproterozoic(2.9-23 Ga),(2) net increase in volume of the continents during Paleo-to Mesoproterozoic(2.3-1.0 Ga), and(3) net decrease in volume of the continents during the Neoproterozoic and Phanerozoic(after 1.0 Ga). In the Archean and Paleoproterozoic, the embryonic continents were smaller than the modern continents, probably owing to the relatively rapid production and destruction of continental crust. This is indeed reflected in the heterogeneous crustal age structure of modern continents that usually have relatively small amount of Archean crusts with respect to the post-Archean ones. During the Mesoproterozoic, plural continents amalgamated into larger ones comparable to modern continental blocks in size. Relatively older crusts were preserved in continental interiors, whereas younger crusts were accreted along continental peripheries.In addition to continental arc magmatism, the direct accretion of intra-oceanic island arc around continental peripheries also became important for net continental growth. Since 1.0 Ga, total volume of continents has decreased, and this appears consistent with on-going phenomena along modern active arc-trench system with dominant tectonic erosion and/or arc subduction. Subduction of a huge amount of granitic crusts into the mantle through time is suggested, and this requires re-consideration of the mantle composition and heterogeneity. | Hikaru Sawada Yukio Isozaki Shuhei Sakata Takafumi Hirata Shigenori Maruyama | 2018 | Geoscience Frontiers2018，9，4： | 4 |
| 5 | 900~2800K多晶石墨电阻率与温度的关系显示文摘1.前言石墨,在惰性气氛下有3300K以上的耐热性,加之它在导电、耐粒子等方面也显示优异的特性,因此作为超高温炉的发热体、宇航材料、原子反应堆用材料等被广泛利用。然而,测定1800K以上的物性,在设备和技术方面是困难的。目前超高温用石墨材料的设计是采用从低温区域得到的石墨数据外推值,再参考经验积累的推断值进行的。因此,开发能够高精度测量炭,石墨材料的电气、机械、高温特性的设备,进而确立可靠性高的评价技术就显得很迫切。有关3300K温度范围内的电导率,虽然美国,苏联已有报告发表,但测试设备和测试条件没有详细说明,并且测试的试样也只局限于特定的石墨种类。 | Masakazu Adachi Hiroshi Shioyama Masaki Narisawa Shigeru Ikeda kuniaki Tatsumi Isao Souma Hideo Isozaki kazunori Egawa Hirofumi Kyutoku Takesi Tanamura 刘培桐 | 1991 | 炭素技术1991，10，4： | 4 |
| 6 | Clinical evaluation of lymph node metastasis in gastric cancer defined by the fifth edition of the TNM classification in comparison with the Japanese system 显示文摘 | Fujii K Isozaki H Okajima E | 1999 | Br J Surg1999，86，5： | 1 |
| 7 | Gain - of- functionmutation of c - kit in human gastrointestinal stromal tumor 显示文摘 | Hirota S Isozaki K Moriiyama Y | 1998 | Science1998，279，5350： | 1 |
| 8 | Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors 显示文摘 | Hirota S Isozaki K Moriyama Y | 1998 | Science1998，279，5350： | 1 |
| 9 | Splenectomy for treatment of gastric cancer:Japanese experience显示文摘 | Okajima K Isozaki H | 1995 | Workd J Surg1995，19，4： | 1 |
| 10 | Impact of the expression of cyclindependent kinase inhibitor p27^kip1 and apoptosis in tumor cells on the overall survival of patients with non-early stage gastric carcinoma显示文摘 | Ohtani M Isozaki H Fujii K etal | 1999 | Cancer1999，85，8： | 1 |
| 11 | An assessment of the feasibility of sentinel lymph node-guided surgery for gastric cancer显示文摘 | Isozaki H Kimura T Tanaka N | 2004 | Gastric Cancer2004，7，3： | 1 |
| 12 | Endoscopic ultrasonography-guided fine needle aspiration biopsy in follow- up patients with gastrointestinal stromal tumors 显示文摘 | Kinoshita K Isozaki K Tsutsui S | 2003 | Eur J Gastroenterol Hepatol2003，15，11： | 1 |
| 13 | Distant lymph node metastasis of early gastric cancer显示文摘 | Isozaki H Okajima K Ichinona T | | 0，，： | 1 |
| 14 | Diferential diagnosis of hepatic tumors by using contrast enhancement patterns at US显示文摘 | Isozaki T Numata K Kiba T | 2003 | Radiology2003，229，： | 1 |
| 15 | Gain-of-function mutaitions of c-kit in human gastrointestinal stromal tumors 显示文摘 | Hirota S Isozaki K Moriyama Y | 1998 | Science1998，279，5350： | 1 |
| 16 | Splenectomy for treatment of gastric cancer:Japanese experience显示文摘 | Okajima K Isozaki H | 1995 | World J Surg1995，19，4： | 1 |
| 17 | Gain-of-function mutations of C-kit in human gastrointe: stinal stromal tumor显示文摘 | Hirota S Isozaki K Moriyama Y | 1998 | Science1998，279，5350： | 1 |
| 18 | Risk factors of esophagojejunal anastomotic leakage after total gastrectomy for gastric cancer显示文摘 | Isozaki H Okajima K Ichinona T | 1997 | Hepatogastroenterology1997，44，17： | 1 |
| 19 | 400 V class high-speed current limiting circuit breaker for electric power system显示文摘 | GENJI T NAKAMURA O ISOZAKI M | 1994 | IEEE Transactions on Power Delivery1994，9，3： | 1 |
| 20 | High-reliability zircon separation for hunting the oldest material on Earth: An automatic zircon separator with image-processing/microtweezers-manipulating system and double-step dating显示文摘Despite the recent development in radiometric dating of numerous zircons by LA-ICPMS, mineral separation still remains a major obstacle, particularly in the search for the oldest material on Earth. To improve the efficiency in zircon separation by an order of magnitude, we have designed/developed a new machine-an automatic zircon separator(AZS). This is designed particularly for automatic pick-up of100 μm-sized zircon grains out of a heavy mineral fraction after conventional separation procedures. The AZS operates in three modes:(1) image processing to choose targeted individual zircon grains out of all heavy minerals spread on a tray,(2) automatic capturing of the individual zircon grains with microtweezers, and(3) placing them one-by-one in a coordinated alignment on a receiving tray. The automatic capturing was designed/created for continuous mineral selecting without human presence for many hours. This software also enables the registration of each separated zircon grain for dating, by recording digital photo-image, optical(color) indices, and coordinates on a receiving tray. We developed two new approaches for the dating; i.e.(1) direct dating of zircons selected by LA-ICPMS without conventional resin-mounting/polishing,(2) high speed U-Pb dating, combined with conventional sample preparation procedures using the new equipment with multiple-ion counting detectors(LA-MIC-ICPMS).With the first approach, Pb-Pb ages obtained from the surface of a mineral were crosschecked with the interior of the same grain after resin-mounting/polishing. With the second approach, the amount of time required for dating one zircon grain is ca. 20 s, and a sample throughput of >150 grains per hour can be achieved with sufficient precision(ca. 0.5%).We tested the practical efficiency of the AZS, by analyzing an Archean Jack Hills conglomerate in Western Australia with the known oldest(>4.3 Ga) zircon on Earth. Preliminary results are positive; we were able to obtain more than 194 zircons that are over 4.0 Ga out of ca. 3800 checked grains, and 9 grains were over 4300 Ma with the oldest at 4371 ± 7 Ma. This separation system by AZS, combined with the new approaches, guarantees much higher yield in the hunt for old zircons. | Yukio Isozaki Shinji Yamamoto Shuhei Sakata Hideyuki Obayashi Takafumi Hirata Ken-ichi Obori Toshinori Maebayashi Satoshi Takeshima Toshikazu Ebisuzaki Shigenori Maruyama | 2018 | Geoscience Frontiers2018，9，4： | 1 |
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