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| 1 | Utility of serological markers in inflammatory bowel diseases: Gadget or magic?显示文摘为煽动性的肠疾病(IBD ) 的血清学标记的面板很快正在膨胀。尽管 anti-Saccharomyces 啤酒抗体(ASCA ) 和不正常的仙子细胞质的抗体(P-ANCA ) 仍然是的原子反 neutrophil 广泛地调查的大多数,试验性的数据的增加的数量在对各种各样的微生物引起的抗原指导的最新发现的抗体上是可得到的。对在当前的 IBD 诊断算法的各种各样的抗体的评价的角色由于他们的有限敏感经常是可疑的。相反,有疾病行为和显型的血清学标记的协会正在变得逐渐地生长得很好。越来越多的观察证实有 Crohn 在高乳头 ers 表示多重血清学标记的疾病的病人是更可能的有复杂的小肠疾病(例如苛评或穿孔) 并且没有,或与抗体的低乳头 ers,比那些在为外科的更高的风险。基于血清学反应创造同质的疾病亚群可以帮助开发更多的标准化治疗学的途径并且可以在 IBD 的 pathomechanism 的更好的理解帮助。进一步未来的临床的研究被需要在 IBD 建立 serologic 的临床的角色。 | Maria Papp Gary L Norman Istvan Altorjay Peter Laszlo Lakatos | 2007 | World Journal of Gastroenterology2007，13，14： | 24 |
| 2 | Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis显示文摘AIM To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis(PSC) patients.METHODS Sera of 67 PSC patients [median age(range): 32(5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin(AAA Ig A/Ig G) and gliadin(AGA Ig A/Ig G)] and for serum level of intestinal fatty acid-binding protein(I-FABP) by ELISA. Markers of lipopolysaccharide(LPS) exposure [LPS binding protein(LBP)] and various antimicrobial antibodies [anti-OMP Plus Ig A and endotoxin core Ig A antibody(Endo CAb)] were also determined. Poor disease outcome was defined as orthotopic liver transplantation and/or liver-related death during the follow-up [median: 99(14-106) mo]. One hundred and fifty-three healthy subjects(HCONT) and 172 ulcerative colitis(UC) patients were the controls. RESULTS A total of 28.4%, 28.0%, 9% and 20.9% of PSC patients were positive for AAA Ig A, AAA Ig G, AGA Ig A and AGA Ig G, respectively. Frequencies of AAA Ig A and AAA Ig G(P < 0.001, for both) and AGA Ig G(P = 0.01, for both) but not AGA Ig A were significantly higher compared to both of the HCONT and the UC groups. In survival analysis, AAA Ig A-positivity was revealed as an independent predictor of poor disease outcome after adjusting either for the presence of cirrhosis [HR = 5.15(1.27-20.86), P = 0.022 or for the Mayo risk score(HR = 4.24(0.99-18.21), P = 0.052]. AAA Ig A-positivity was significantly associated with higher frequency of antimicrobial antibodies(P < 0.001 for Endo Cab Ig A and P = 0.012 for anti-OMP Plus Ig A) and higher level of the enterocyte damage marker(median I-FABP_(AAA Ig A pos vs neg): 365 vs 166 pg/m L, P = 0.011), but not with serum LBP level. CONCLUSION Presence of Ig A type AAA identified PSC patients with progressive disease. Moreover, it is associated with enhanced mucosal immune response to various microbial antigens and enterocyte damage further highlighting the importance of the gut-liver interaction in PSC. | Tamas Tornai Eszter Palyu Zsuzsanna Vitalis Istvan Tornai David Tornai Peter Antal-Szalmas Gary L Norman Zakera Shums Gabor Veres Antal Dezsofi Gabriella Par Alajos Par Peter Orosz Ferenc Szalay Peter Laszlo Lakatos Maria Papp | 2017 | World Journal of Gastroenterology2017，23，29： | 5 |
| 3 | Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012显示文摘AIM: To analyze the prevalence, length and predictors of hospitalization in the biological era in the populationbased inception cohort from Veszprem province.METHODS: Data of 331 incident Crohn's disease(CD) patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed(median age at diagnosis: 28; IQR: 21-40 years). Both in- and outpatient records were collected and comprehensively reviewed.RESULTS: Probabilities of first CD-related hospitalization and re-hospitalization were 32.3%, 45.5%,53.7% and 13.6%, 23.9%, 29.8%, respectively after one, three and five years of follow-up in Kaplan-Meier analysis. First-year hospitalizations were related to diagnostic procedures(37%), surgery or disease activity(27% and 21%). Non-inflammatory disease behavior at diagnosis(HR = 1.32, P = 0.001) and perianal disease(HR = 1.47, P = 0.04) were associated with time to first CD-related hospitalization, while disease behavior change(HR = 2.38, P = 0.002) and need for steroids(HR = 3.14, P = 0.003) were associated with time to first re-hospitalization in multivariate analyses.Early CD-related hospitalization(within the year of diagnosis) was independently associated with need for immunosuppressives(OR = 2.08, P = 0.001) and need for surgeries(OR = 7.25, P < 0.001) during the disease course.CONCLUSION: Hospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and rehospitalization. | Petra A Golovics Laszlo Lakatos Michael D Mandel Barbara D Lovasz Zsuzsanna Vegh Zsuzsanna Kurti Istvan Szita Lajos S Kiss Tunde Pandur Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 4 | Synth-esis of D-ristosamine and its derivatives显示文摘 | ISTVAN P SZTARICSKAI F SZILAGY L | 1979 | Carbohydr Res1979，68，： | 1 |
| 5 | Synthesis and complexation properties of a new macrocyclic polyaza polyphosphinate ligand显示文摘 | Istvan L Dean S Ravichandran R | 1991 | Inorg Chem1991，30，26： | 1 |
| 6 | Co-operative production plan- ning for small and medium-sized enterprises显示文摘 | Istvan T Gyorgy L K Paolo P | 2000 | International Journal of Production Economics2000，64，1： | 1 |
| 7 | Composite bioceramics in the system hydroxyapatite (fluorapatite)-yttria stabilized zirconia显示文摘 | Margrita D L Peter L Istvan S | 1995 | Adv Sci Technol1995，12，： | 1 |
| 8 | Composite bioceramics in the system hydroxyapatite (fluorapatite)-yttria stabilized zirconia显示文摘 | Margrita D L Peter L Istvan S | 1995 | Adv SciTechnol1995，12，： | 1 |
| 9 | Phage pattem and antibiotic resistance pattern of coagulase negative staphylococci obtained from immuno compromised patient显示文摘 | Istvan B Agnes H Andras L | 1992 | Microbiol Immunol1992，36，9： | 1 |
| 10 | Down-Regulation of Weel Kinase by a SpeciflcSubset of microRNA in Human Sporadic Pityita- ry Adenomas显示文摘 | Henriett B Istvan L Sandor C | 2010 | J Clin Endocrinol Metab2010，95，10： | 1 |
| 11 | Effects of silymain (Legalon) treatment on the antioxidant deffence system and lipid peroxidation in patients with chronic alcoholic liver disease (a double-blind study)显示文摘 | GYORGY M GYORGY D ISTVAN L | 1990 | Orv Hetil1990，131，16： | 1 |
| 12 | Geographical origin identification of pure Sri Lanka tea infusions with electronic nose,electronic tongue and sensory profile analysis显示文摘 | ZOLTAN K ISTVAN D LARINA L | | 0，，： | 1 |
| 13 | Geographical origin identification of pure Sri Lanka tea infusions with electronic nose,electronic tongue and sensory profile analysis显示文摘 | ZOLTAN K ISTVAN D LARINA L | | 0，，24： | 1 |
| 14 | Serum cathepsin B and plasma urokinase-type plasminogen activator levels in gastrointestinal tract cancers显示文摘 | Herszenyi L Istvan G Cardin R | 2008 | Eur J Cancer Prey2008，17，5： | 1 |
| 15 | Mixed micelles of fluorinated and hydrogenated surfactants 显示文摘 | NORDSTIERNA L ISTVAN FURQ STILBS P | 2006 | J Am Chem Soc2006，，128： | 1 |
| 16 | Preliminary studies on the genetic variability of six Hungarian common carp strains using microsatellite DNA markers显示文摘 | Istvan L Istvan M Csaba H | 2005 | Hydrobiologia2005，533，： | 1 |
| 17 | The bindingavidity of a nanoparticle-based multivalent targeted drug deliveryplatform显示文摘 | SEUNGPYO H PASCALE R L ISTVAN J M | 2007 | Chem Biol2007，14，1： | 1 |
| 18 | Structural vulnerability of the North American power grid显示文摘 | Albert Reka Albert Istvan Nakarado Gary L | 2004 | Physical Review E-Statistical Nonlinear and Soft Matter Physics2004，69，22： | 1 |
| 19 | Rock mechanics for gas storage in bedded salt caverns显示文摘 | ISTVAN J A EVANS L J WEBER J H | 1997 | Int J Rock Mech Min Sci1997，34，： | 1 |
| 20 | Rock mechanics for gas storage in bedded salt caverns显示文摘 | ISTVAN JA EVANS L J WEBER J H | 1997 | International Journal of Rock Mechanics and Mining Sciences1997，34，34： | 1 |
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