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| 1 | Risk factors for bleeding after endoscopic mucosal resection显示文摘AIM: To clarify the risk factors for bleeding after endoscopic mucosal resection (EMR).METHODS: A total of 297 consecutive patients who underwent EMR were enrolled. Some of the patients had multiple lesions. Bleeding requiring endoscopic treatment was defined as bleeding after EMR. Odds ratios (OR) with 95% confidence intervals (CI), calculated by logistic regression with multivariate adjustments for covariates,were the measures of association.RESULTS: Of the 297 patients, 57 (19.2%) patients with bleeding after EMR were confirmed. With multivariate adjustment, the cutting method of ENR, diameter, and endoscopic pattern of the tumor were associated with the risk of bleeding after ENR. The multivariate-adjusted OR for bleeding after EMR using endoscopic aspiration mucosectomy was 3.07 (95%CI, 1.59-5.92) compared with strip biopsy. The multiple-adjusted OR for bleeding after EMR for the highest quartile (16-50 mm) of tumor diameter was 5.63 (95%CI, 1.84-17.23) compared with that for the lowest (4-7 mm). The multiple-adjusted OR for bleeding after EM R for depressed type of tumor was 4.21 (95%CI, 1.75-10.10) compared with elevated type.CONCLUSION: It is important to take tumor characteristics (tumor size and endoscopic pattern) and cutting method of EMR into consideration in predicting bleeding after ENR. | Masatsugu Shiba Kazuhide Higuchi Kaori Kadouchi Ai Montani Kazuki Yamamori Hirotoshi Okazaki Makiko Taguchi Tomoko Wada Atsushi Itani Toshio Watanabe Kazunari Tominaga Yoshihiro Fujiwara Tomoshige Hayashi Kei Tsumura Tetsuo Arakawa | 2005 | World Journal of Gastroenterology2005，11，46： | 25 |
| 2 | Stem cells in neuroinjury and neurodegenerative disorders: challenges and future neurotherapeutic prospects显示文摘The prevalence of neurodegenerative diseases and neural injury disorders is increasing worldwide. Research is now focusing on improving current neurogenesis techniques including neural stem cell therapy and other biochemical drug-based approaches to ameliorate these disorders. Unfortunately, we are still facing many obstacles that are rendering current neurotherapies ineffective in clinical trials for reasons that are yet to be discovered. That is why we should start by fully understanding the complex mechanisms of neurogenesis and the factors that affect it, or else, all our suggested therapies would fail since they would not be targeting the essence of the neurological disorder but rather the symptoms. One possible paradigm shift is to switch from neuroprotectant therapies towards neurodegeneration/neurorestorative approaches. In addition, other and our laboratories are increasingly focusing on combining the use of pharmacological agents(such as Rho-associated kinase(ROCK) inhibitors or other growth factors(such as brain-derived neurotrophic factor(BDNF)) and stem cell treatment to enhance the survivability and/or differentiation capacity of transplanted stem cells in neurotrauma or other neurodegeneration animal models. Ongoing stem cell research is surely on the verge of a breakthrough of multiple effective therapeutic options for neurodegenerative disorders. Once, we fully comprehend the process of neurogenesis and its components, we will fully be capable of manipulating and utilizing it. In this work, we discuss the current knowledge of neuroregenerative therapies and their associated challenges. | Tarek H.Mouhieddine Firas H.Kobeissy Muhieddine Itani Amaly Nokkari Kevin K.W.Wang | 2014 | Neural Regeneration Research2014，9，9： | 9 |
| 3 | Influence of earthquake ground motion incoherency on multi-support structures显示文摘A linear response history analysis method is used to determine the influence of three factors: geometric incoherency, wave-passage, and local site characteristics on the response of multi-support structures subjected to differential ground motions. A one-span frame and a reduced model of a 24-span bridge, located in Las Vegas, Nevada are studied, in which the influence of each of the three factors and their combinations are analyzed. It is revealed that the incoherency of earthquake ground motion can have a dramatic influence on structural response by modifying the dynamics response to uniform excitation and inducing pseudo-static response, which does not exist in structures subjected to uniform excitation. The total response when all three sources of ground motion incoherency are included is generally larger than that of uniform excitation. | 杨庆山 M.Saiid Saiidi 王航 Ahmad Itani | 2002 | Earthquake Engineering and Engineering Vibration2002，1，2： | 9 |
| 4 | Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis显示文摘BACKGROUND The coexistence of sarcopenia and obesity is referred to as sarcopenic obesity(SO)and it has been hypothesized that the two components of SO may synergistically increase their negative effects. However, many uncertainties still surround this condition especially with regard to its potential negative effects on health outcomes.AIM To conduct a systematic review to determine the prevalence of sarcopenia among adults with overweight and obesity and to investigate whether SO was associated with a higher risk of type 2 diabetes(T2 D).METHODS This study was conducted in adherence with the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. Literature searches, study selection, methodology development and quality appraisal were performed independently by two authors and the data were collated by means of metaanalysis and narrative synthesis.RESULTS Of the 606 articles retrieved, 11 studies that comprised a total of 60118 adults with overweight and obesity of both genders met the inclusion criteria and were reviewed, revealing two main findings. First, the overall prevalence of sarcopenia is 43% in females and 42% in males who are with overweight and obesity.Secondly, the presence of SO increases the risk of T2D by 38% with respect to those without SO(OR = 1.38, 95%CI: 1.27-1.50).CONCLUSION A high prevalence of sarcopenia has been found among adults with overweight and obesity regardless of their gender and this condition seems to be associatedwith a higher risk of T2D. Clinician should be aware of this scenario in their clinical practice for the better management of both obesity and T2D. | Dima Khadra Leila Itani Hana Tannir Dima Kreidieh Dana El Masri Marwan El Ghoch | 2019 | World Journal of Diabetes2019，10，5： | 6 |
| 5 | Effect of mucin production on survival in colorectal cancer:A case-control study显示文摘AIM: To investigate the impact of mucin production on prognosis in colorectal cancer, in terms of overall survival (OS) and time to disease progression (TTP) in patients with mucinous compared to those with non-mucinous colorectal cancer (NMCRC), matched for age, gender, and tumor stage.METHODS: Thirty five patients with mucinous colorectal cancer (MCRC) were matched for age, gender, and tumor stage with 35 controls having NMCRC. OS and TTP were compared among 4 groups divided according to mucin content: group A (50%-75% mucin), group B (75%-100% mucin), group C or controls (< 50% mucin). Group D consisted of all patients with tumors having < 75% mucin (controls and groups A together).RESULTS: Median survival in MCRC and NMCRC groups was 46.2 and 112.9 mo, respectively (P = 0.26). OS in groups A and B was 70.1 and 32.8 mo (P = 0.46), and in groups B and D was 32.8 and 70.1 mo, respectively (P = 0.143). TTP in MCRC and NMCRC was 50.17 and 44.77 mo, respectively (P = 0.795). TTP in groups A, B, and D was 70.1, 24.8, and 65.5 mo, respectively. Twenty-eight percent of patients with MCRC had poorly differentiated adenocarcinoma versus 8.6% in NMCRC patients (P = 0.028).CONCLUSION: MCRC is associated with a non-significant decrease in median survival and TTP, particularlywhen mucin content is > 75% of tumor volume. However, it tends to be more poorly differentiated. A larger study matching for stage and grade is needed. | Mirna H Farhat Kassem A Barada Ayman N Tawil Doha M Itani Hassan A Hatoum Ali I Shamseddine | 2008 | World Journal of Gastroenterology2008，14，45： | 6 |
| 6 | Myxedema ascites with high CA-125:Case and a review of literature显示文摘Ascites appearing in a previously healthy female patient is usually ascribed to a variety of causes,among which,is a cancerous process,especially if it comes with a raised CA-125 level.Although the CA-125 antigen is present on more than 80% of malignant epithelial ovarian tissue of non-mucinous type,it is also found on both healthy and malignant cells of mesothelial and non-mesothelial origin.Myxedema ascites which is caused by hypothyroidism is a rare entity,but on the other hand is easy to treat.It is one of the differential diagnoses when the ascites is refractory to treatment and no other obvious cause can be identified.If the diagnosis is delayed,patients will frequently receive unnecessary procedures,while treatment has very good response rates and ascites resolve with serum CA-125 normalization after adequate hormonal treatment. | Bou Khalil Roula El Rassi Patrick Chammas Nizar Obeid Jean Ghabach Maroun Sakr Charles Itani Tarek Farhat Said | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 7 | 开放与腹腔镜下腹壁切口疝修补术术后并发症的分级和评估:前瞻性随机对照研究显示文摘目的介绍一种针对腹部切口疝修补术后并发症的评估方法。方法 2004-2006年间,146例病人被随机分为两组,一组接受腹腔镜切口疝修补术(腹腔镜组,n=73),另一组接受传统开放式切口疝修补术(传统组,n=73)。研究对象是术后8周内出现的并发症。利用'三步法'来评价并发症的严重性。首先,将所有并发症根据Clavien分级分类。第二步,5位研究员分别独自运用直观叙述问卷模式对并发症的严重程度分级:0表示无术后并发症,100表示术后死亡。第三步,分别用中位数、最低和最高值对腹腔镜组与传统组术后并发症进行评价。结果传统组术后并发症发生率要显著高于腹腔镜组(47.9%vs.31.5%,P=0.026),而腹腔镜组术后并发症的严重度高于传统组。非参数分析显示传统组术后并发症发生率较高(四分位数间距为:开放组0-20对比腹腔镜组0-10;P=0.049)。在敏感性比较中,中位数、最高值和最低值获得了类似结果。结论该方法可以对两种术式术后并发症的发生做出直接评价。评估方法的合法性、可靠性和普遍性有待进一步的研究证实。 | Kaafarani HMA Hur K Campasano M Reda DJ Itani KMF | 2011 | 中国实用外科杂志2011，31，4： | 4 |
| 8 | Response of a 2-story test-bed structure for the seismic evaluation of nonstructural systems显示文摘A full-scale,two-story,two-by-one bay,steel braced-frame was subjected to a number of unidirectional ground motions using three shake tables at the UNR-NEES site.The test-bed frame was designed to study the seismic performance of nonstructural systems including steel-framed gypsum partition walls,suspended ceilings and fire sprinkler systems.The frame can be configured to perform as an elastic or inelastic system to generate large floor accelerations or large inter story drift,respectively.In this study,the dynamic performance of the linear and nonlinear test-beds was comprehensively studied.The seismic performance of nonstructural systems installed in the linear and nonlinear test-beds were assessed during extreme excitations.In addition,the dynamic interactions of the test-bed and installed nonstructural systems are investigated. | Siavash Soroushian E. “Manos” Maragakis Arash E. Zaghi Esmaeel Rahmanishamsi Ahmad M. Itani Gokhan Pekcan | 2016 | Earthquake Engineering and Engineering Vibration2016，15，1： | 3 |
| 9 | Autoimmune pancreatitis complicated by gastric varices:A report of 3 cases显示文摘We present three cases of autoimmune pancreatitis(AIP) complicated by gastric varices.Case 1:A 57-yearold man was diagnosed with AIP complicated by gastric varices and splenic vein obstruction.Splenomegaly was not detected at the time of the diagnosis.The AIP improved using steroid therapy,the splenic vein was reperfused,and the gastric varices disappeared;case 2:A 55-year-old man was diagnosed with AIP complicated by gastric varices,splenic vein obstruction,and splenomegaly.Although the AIP improved using steroid therapy,the gastric varices and splenic vein obstruction did not resolve;case 3:A 68-year-old man was diagnosed with AIP complicated by gastric varices,splenic vein obstruction,and splenomegaly.The gastric varices,splenic vein obstruction,and AIP did not improve using steroid therapy.These three cases suggest that gastric varices or splenic vein obstruction without splenomegaly may be an indication for steroid therapy in patients with AIP because the complications will likely become irreversible over time. | Norihiro Goto Jun Mimura Toshinao Itani Motohito Hayashi Yukari Shimada Tomoaki Matsumori | 2012 | World Journal of Gastroenterology2012，18，31： | 2 |
| 10 | Linezolid reduces length of stay and duration of intravenous treatment compared with vancomycin for complicated skin and soft tissue infections due to suspected or proven methicillin-resistant Staphylococcus aureus (MRSA)显示文摘 | Itani K M Weigelt J Li J Z | 2005 | lnt J Antimicrob Agents2005，26，6： | 1 |
| 11 | Management of recur- rent inguinal hernias显示文摘 | Itani KM Fitzgibbons R Jr Awad SS | 2009 | J Am Coil Surg2009，209，65： | 1 |
| 12 | Clinical Efficacy of Oral Linezolid Compared With Intravenous Vancomycin for the Treatment of Methicillin-Resistant Staphylococcus aureus –Complicated Skin and Soft Tissue Infections: A Retrospective, Propensity Score–Matched, Case-Control Analysis显示文摘 | Kamal M.F. Itani Pinaki Biswas Arlene Reisman Helen Bhattacharyya Alice M. Baruch | 2012 | Clinical Therapeutics2012，，8： | 1 |
| 13 | Linezolid versus vancomycin in treatment of complicated skin and soft tissue infections 显示文摘 | Weigeh J Itani K Stevens D | 2005 | Antimicrob Agents Chemother2005，49，： | 1 |
| 14 | Chemical and sensory evalution of aromatic rice cuhivars显示文摘 | Itani T Takada A Tamaki M | 1994 | Crop Science1994，34，： | 1 |
| 15 | Laparoscopic inguinal hernia repair 显示文摘 | Neumayer L Fitzgibbons R Jr Itani K | 2005 | J Am Coll Surg2005，201，3： | 1 |
| 16 | Management of recurrent inguinal herinas显示文摘 | Itani KMF Fitzgibbons JrR Award SS | | 0，，5： | 1 |
| 17 | Predictors of Comprehension during Surgical Informed Consent显示文摘 | Aaron S. Fink Allan V. Prochazka William G. Henderson Debra Bartenfeld Carsie Nyirenda Alexandra Webb David H. Berger Kamal Itani Thomas Whitehill James Edwards Mark Wilson Cynthia Karsonovich Patricia Parmelee | 2010 | Journal of the American College of Surgeons2010，，6： | 1 |
| 18 | Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha 显示文摘 | Itani SI Ruderman NB Schmieder F | 2002 | Diabetes2002，51，7： | 1 |
| 19 | MicroRNA-21 correlates with tumorigenesis in malignant peripheral nerve sheath tumor (MPNST) via programmed cell death protein 4 (PDCD4)显示文摘 | Itani S Kunisada T Morimoto Y | | 0，，： | 1 |
| 20 | Variation of 2-acetyl- 1-pyrroline concentration in aromatic rice grains collect- ed in the same region in Japan and factors affecting its concentration 显示文摘 | Itani T Tamaki M Hayata Y | 2004 | Plant Production Science2004，7，2： | 1 |
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