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| 1 | Hepatic ischemic preconditioning increases portal vein flow in experimental liver ischemia reperfusion injury显示文摘BACKGROUND: Ischemic preconditioning(IPC) has been shown to decrease liver injury and to increase hepatic microvascular perfusion after liver ischemia reperfusion. This study aimed to evaluate the effects of IPC on hemodynamics of the portal venous system. METHODS: Thirty-two rats were randomized into two groups: IPC group and control group. The rats of the IPC group underwent IPC by 10 minutes of liver ischemia followed by 10 minutes of reperfusion before liver ischemia, and the rats of the control group were subjected to 60 minutes of partial liver ischemia. Non-ischemic lobes were resected immediately after reperfusion. The animals were studied at 4 hours and 12 hours after reperfusion. Mean arterial pressure, heart rate, portal vein flow and pressure were analyzed. Blood was collected for the determination of the levels of aspartate aminotransferase, alanine aminotransferase, calcium, lactate, pH, bicarbonate, and base excess. RESULTS: IPC increased the mean portal vein flow at 4 hours and 12 hours after reperfusion. IPC recovered 78% of the meanportal vein flow at 12 hours after reperfusion. IPC decreased the levels of aspartate aminotransferase, alanine aminotransferase and lactate, and increased the levels of ionized calcium, bicarbonate and base excess at 12 hours after reperfusion. CONCLUSIONS: This study demonstrated that IPC increases portal vein flow and enhances hepatoprotective effects in liver ischemia reperfusion. The better recovery of portal vein flow after IPC may be correlated with the lower levels of transaminases and with the better metabolic profile. | Estela RR Figueira Joel A Rocha-Filho Mauro Nakatani Marcelo FS Buto Eduardo R Tatebe Vitor O Andre Ivan Cecconello Luiz AC D'Albuquerque | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，1： | 6 |
| 2 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 3 | HLA-Haploidentical Bone Marrow Transplantation for Hematologic Malignancies Using Nonmyeloablative Conditioning and High-Dose, Posttransplantation Cyclophosphamide显示文摘 | Leo Luznik Paul V. O'Donnell Heather J. Symons Allen R. Chen M. Susan Leffell Marianna Zahurak Ted A. Gooley Steve Piantadosi Michele Kaup Richard F. Ambinder Carol Ann Huff William Matsui Javier Bola?os-Meade Ivan Borrello Jonathan D. Powell Elizabeth Ha | 2008 | Biology of Blood and Marrow Transplantation2008，，6： | 4 |
| 4 | Transgene and mitochondrial DNA are indicators of efficient composting of transgenic pig carcasses显示文摘 | Dave Murray Roy G. Meidinger Serguei P. Golovan John P. Phillips Ivan P. O’Halloran Ming Z. Fan Roger R. Hacker Cecil W. Forsberg | 2006 | Bioresource Technology2006，，9： | 1 |
| 5 | Aggregation Properties and Mixing Behavior ofHydrocarbon,Fluorocarbon,and Hylbrid Hydrocarbon Fluorocarbon Cationic DimericSurfactants显示文摘 | Reiko O Ivan H | 2000 | Langmuir2000，16，25： | 1 |
| 6 | Intrinsic time-scale decomposition:timefreqeucny-energy analysis and real-time filtering of non-station-ary signals显示文摘 | MARK G F IVAN O | 2007 | Proceedings of the Royal Society A2007，463，： | 1 |
| 7 | A concise synthesis of the octalactins显示文摘 | O'Sul ivan P T Buhr W Fuhry M A M | | 0，，07： | 1 |
| 8 | The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse 显示文摘 | Jacob PR Jacobsen Ivan O Medvedev | 2012 | Phil Trans R Soc B2012，367，5： | 1 |
| 9 | Deciphering the complexity of Toll-like receptor signaling显示文摘 | Renato O Ivan Z Francesca G | 2010 | Cellular and Molecular Life Sciences2010，67，： | 1 |
| 10 | Is Mitral Valve Repair Safe Procedure in Elderly Patients?显示文摘 | Igor Medved Darko Ani? Marin O?tri? Boris Zrni? Aldo Ivan?i? Vjekoslav Tomuli? | 2010 | Collegium Antropologicum2010，，2： | 1 |
| 11 | Optical properties of metal nanoparticles with arbitrary shapes显示文摘 | Ivan O Sosa Cecila Noguez Ruben G Barrera | 2003 | Journal of Physical Chemistry B2003，107，26： | 1 |
| 12 | Water-soluble derivative of propolis and its polyphenolic compounds enhance tumoricidal activity of macrophages显示文摘 | NADA O IVAN B | 2005 | J Ethnopharmaco2005，102，1： | 1 |
| 13 | Selenium concentration in wheat grain:Is there sufficient genotypic variation to use in breeding显示文摘 | Graham L Ivan O M James S | 2005 | Plant and Soil2005，，： | 1 |
| 14 | Computing Localized Power-efficient Data Aggregation Tree for Sensor Networks 显示文摘 | Huseyin O T Ibraihim K Ivan S | 2011 | IEEE Transactions on Parallel and Distributed Systems2011，22，3： | 1 |
| 15 | Effects of the root lesion nematode, Pratylenchus thornei, on wheat yields in Mexico显示文摘 | Julie M Nicol Ivan O M | 2004 | Nernatology2004，6，4： | 1 |
| 16 | A framework instantiation approach based on the Features Model显示文摘 | MATHIAS F IVAN DE O | 2004 | The Journal of Systems and Software2004，732，： | 1 |
| 17 | Mapping the Distribution of DDT Residues as DDE in the Soils of the Irrigated Regions of Northern New South Wales, Australia Using ELISA and GIS显示文摘 | Shivaramaiah H M Odeh I O A Kennedy Ivan R | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 18 | SJES14121200095083显示文摘 | Sonia A. Melo Hikaru Sugimoto Joyce T. O’Connell Noritoshi Kato Alberto Villanueva August Vidal Le Qiu Edward Vitkin Lev T. Perelman Carlos A. Melo Anthony Lucci Cristina Ivan George A. Calin Raghu Kalluri | 2014 | Cancer Cell2014，，5： | 1 |
| 19 | Aggregation properties and mixing behavior of hydrocarbon, fluorocarbon, and hydrocarbon - fluorocarbon cationic dimeric surfactants 显示文摘 | REIKO O IVAN H | 2000 | Langmuir2000，16，25： | 1 |
| 20 | Thermal Effects in Cellulose Pyrolysis: Relationship to Char formation Processes显示文摘 | Ivan M Vahur O Eric M S | 1996 | Ind Eng Chem Res1996，35，3： | 1 |
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