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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | De- termination of undegradable intake protein digestibility of forages using the mobile nylon bag technique 显示文摘 | HAUGEN H L IVAN S K MAC DONALD J C | 2006 | J Anita Sci2006，84，： | 1 |
| 3 | Glycolyzed poly (ethylene terephthalate) waste and castor oil - based polyols for waterborne polyurethane adhesives containing hexamethoxymethyl melamine显示文摘 | SUZANA M C IVAN S R MILENA M | 2015 | Progress in Organic Coatings2015，78，： | 1 |
| 4 | Crystallization and thermal properties in waterborne polyurethane elasto- mers:Influence of mixed soft segment block显示文摘 | SUZANA M C IVAN S R IVAN K | 2014 | Materials Chemistry and Physics2014，144，： | 1 |
| 5 | Association between nailfold capillaroscopy findings and pulmonary function tests in patients with systemic sclerosis 显示文摘 | Ivan C Carmen Pilar SA Menica S etal | 2015 | J Rheumatol2015，42，2： | 1 |
| 6 | On the Estimation of Technical Inefficiency in the Stochastic Frontier Production Function Model显示文摘 | James Jondrow C A Knox Lovell Ivan S Materov Peter Schmidt | 1982 | Journal of Econometrics1982，19，23： | 1 |
| 7 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 8 | Pollinator of Helleborus niger in Slovenian naturally occurring populations显示文摘 | ANDRFJ (S)U(S)EK ANTON IVAN (C) I (C) | 2006 | Acta agriculture Slovenica2006，87，： | 1 |
| 9 | Identifica- tion of two major vlrion protein genes of white spot syndrome vires of shrlmp显示文摘 | IVan Huhen M C W Westenberg M Goodall S D | 2000 | Virology2000，266，： | 1 |
| 10 | Thermophysical propcrties of biporous heat pipe evaporators显示文摘 | TADEJ S LIN Ying-Yu IVAN C | 2008 | Journal of Heat Transfer2008，，： | 1 |
| 11 | Effect of partitioning equilibria on the activity of β-galaetosidase in heterogeneous media 显示文摘 | Julieta M S Ivan C Maria A P | 2005 | Biophysical Chemistry2005，118，2： | 1 |
| 12 | Thermal development of microstructure and precipitation effects in Mg-10%wtGd alloy显示文摘 | JAKUB C IVAN P BOHUMIL A IVANA S RADOMIR K ZDENEK M J VIKTOR C | 2006 | Phys Star A2006，203，： | 1 |
| 13 | Membrane Bioreactor (MBR)as an dvanced Wastewater Treatment Technology显示文摘 | Jelena Radjenovi(c) Marin Mato(s)i(c) Ivan Mijatovi(c) Mira Petrovi(c) Damiá Barcel ó | | 0，，02： | 1 |
| 14 | A Study of Partial Discharges from Water Droplets on a Silicone Rubber Insulating Surface显示文摘 | IVAN J S L SHESHA H J EDWARD A C | 2001 | IEEE Transactions on Dielectrics and Electrical Insulation2001，4，8： | 1 |
| 15 | Forest floor CO2 fluxes estimated by eddy covariance and chamber-based model 显示文摘 | Ivan A J Andrew S K Reinhart C | 2001 | Agricultural and Forest Meteorology2001，106，： | 1 |
| 16 | Optical characteristics of one-dimensional Si/SiO2 photonic crystals for thermophotovoltaic applications显示文摘 | FRANCIS S IVAN C NATALIJA J | 2005 | J Appl Phys2005，97，03： | 1 |
| 17 | Protective effect of quercetin and luteolin in human melanoma HMB-2 cells显示文摘 | KATARNA H A IVAN C LIVIA S A | 2005 | Mutation Research2005，565，： | 1 |
| 18 | Glycolyzed products from PET waste and their application in synthesis of polyurethane dispersions 显示文摘 | SUZANA M C IVAN S R MILENA M C | 2012 | Progress in Organic Coatings2012，74，： | 1 |
| 19 | On the estimation of technical inefficiency in the stochastic frontierproduction function mdoel显示文摘 | James Jondrow Lovell C Knox Ivan S Materov | 1982 | Journal of Econometics1982，19，： | 1 |
| 20 | On the Estimation of Technical Inefficiency in theStochastic Frontier Production Function Model显示文摘 | Jondrow J Knox Lovell C A Materov Ivan S Schmidt Peter | 1982 | Journal of Econometrics1982，19，23： | 1 |
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