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| 1 | Evaluation of the sperm DNA fragmentation index in infertile Japanese men by in-house flow cytometric analysis显示文摘Semen analysis has long been used to evaluate male fertility.Recently,several sperm function tests have been developed.Of those,the sperm DNA fragmentation index(DFI),which describes the status of the sperm DNA,is thought to be a suitable parameter for evaluating male fertility.However,there have been no large-scale studies on the sperm DFI of Japanese men.Therefore,we investigated the feasibility of using an in-house flow cytometry-based sperm DFI analysis based on the sperm DNA fragmentation test of sperm chromatin structure assay(SCSA)to assess male fertility in Japan.This study enrolled 743 infertile and 20 fertile Japanese men.To evaluate reproducibility,inter-and intraobserver precision was analyzed.A receiver operating characteristic curve analysis was used to set a cutoff value for the sperm DFI to identify men who could father children by timed intercourse or intrauterine insemination.The variability of the sperm DFI among fertile volunteers was determined.The relationship between semen parameters and the sperm DFI was assessed by Spearman’s rho test.A precision analysis revealed good reproducibility of the sperm DFI.The cutoff value of sperm DNA fragmentation in infertile men was 24.0%.Semen volume had no relationship with the sperm DFI.Sperm concentration,sperm motility,total motile sperm count,and percentage of normal-shaped sperm were significantly and negatively correlated with the sperm DFI.The median sperm DFI was smaller in fertile volunteers(7.7%)than that in infertile men(19.4%).Sperm DNA fragmentation analysis can be used to assess sperm functions that cannot be evaluated by ordinary semen analysis. | Akiyoshi Osaka Hiroshi Okada Sae Onozuka Takashi Tanaka Toshiyuki Iwahata Yukihito Shimomura Yoshitomo Kobori Kazutaka Saito Kouhei Sugimoto | 2022 | Asian Journal of Andrology2022，24，1： | 2 |
| 2 | Hormonal therapy(hCG and rhFSH) for infertile men with adult-onset idiopathic hypogonadotropic hypogonadism显示文摘 | Kobori Y Suzuki K Iwahata T et M | 2015 | Systems biology in reproductive medicine2015，61，2： | 1 |
| 3 | Inflammatory bowel disease in subfertile men and the effect of mesalazine on fertility显示文摘 | Takeshi Shin Yoshitomo Kobori Keisuke Suzuki Toshiyuki Iwahata Hiroshi Yagi Shigehiro Soh Gaku Arai Hiroshi Okada | 2014 | Systems Biology in Reproductive Medicine2014，，： | 1 |
| 4 | Aminoacids and minerals in ancient remnants of fish sauce(garum)sampled in the “Garum Shop” of Pompeii,Italy显示文摘 | Miro Smriga Toshimi Mizukoshi Daigo Iwahata | 2010 | Journal ofFood Composition and Analysis2010，23，5： | 1 |
| 5 | Amino acids and minerals in ancient remnants of fish sauce ( garum ) sampled in the 'Garum Shop' of Pompeii, Italy 显示文摘 | SMRIGA M MIZUKOSHI T IWAHATA D | 2010 | Journal of Food Composition and Analysis2010，23，5： | 1 |
| 6 | Amino acids andminerals in ancient remnants of fish sauce(garum)sampled in the GarumShop of Pompeii,Italy显示文摘 | SMRIGA M MIZUKOSHI T IWAHATA D | 2010 | Journal of Food Composition and Analysis2010，23，5： | 1 |
| 7 | Amino acids and minerals in ancient remnants of fish sauce(garum)sampled in the 'Garuln Shop' of Pompeii,Italy显示文摘 | Smriga M Mizukoshi T Iwahata D | | 0，，05： | 1 |
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