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| 1 | Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice显示文摘Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in mineralization.Collectively, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone. | Eric E Beier Tzong-Jen Sheu Emily A Resseguie Masahiko Takahata Hani A Awad Deborah A Cory-Slechta J Edward Puzas | 2017 | Bone Research2017，5，2： | 3 |
| 2 | Effectiveness and complications of mitomycin C use during pediatric glaucoma surgery 显示文摘 | A1 - Hazmi A Zwaan J Awad A | 1998 | Ophthalmology1998，105，10： | 1 |
| 3 | Expermental measure ment of the vortex development downstream of a lobed forced mixer显示文摘 | Eckerie W A Sheibani H Awad J | 1992 | Journal of Engineering for Gas Turbines and Power1992，114，1： | 1 |
| 4 | Orthodromic median and ulnar fourth digit sensory conductions in mild carpal tunnel syndrome显示文摘 | Uncini A Di Muzio A Cutarella R Awad J Gambi D | 1990 | Neurophysiol Clin1990，20，1： | 1 |
| 5 | Effects of luminal deoxynivalenol and L-proline on eleetrophysiologieal parameters in the jejunums of lay- ing hens 显示文摘 | Awad W A Rehman H Bohm J | 2005 | Poultry Science2005，84，6： | 1 |
| 6 | Preliminary studies of a newly developed subunit vaccine for channel cat- fish virus disease 显示文摘 | AWAD M A NUSBAUM K E BRADY Y J | 1989 | Journal of Aquatic Animal Health1989，1，7： | 1 |
| 7 | Decontamination and detoxification strategies for the Fusarium mycotoxin deoxyni- valenol in animal feed and the effectiveness of microbial biodeg- radation 显示文摘 | AWAD W A GHAREEB K BOHM J | 2010 | Food Additives & Contaminants Part A Chemistry Analysis Control Exposure & Risk Assessment2010，27，4： | 1 |
| 8 | In vitro effects of deoxynivalenol on small intestinal D-glucose uptake and absorp- tion of deoxynivalenol across the isolated jejunal epithelium of lay- ing hens显示文摘 | Awad W A Aschenbach J R Setyabud: F | 2007 | Poultry Science2007，86，1： | 1 |
| 9 | Effect of addition of a probiotic microorganism to'broiler diets contaminated with deoxynivalenol on performance and histological alterations of in- testinal villi of broiler chickens显示文摘 | Awad W A Bohm J Razzazi-Fazeli E | 2006 | Poultry Science2006，85，6： | 1 |
| 10 | In vitro effects of deoxynivalenol on small intestinal D-glucose uptake and absorp- tion of deoxynivalenol across the isolated jejunal epithelium of lay- ing hens显示文摘 | Awad W A Aschenbach J R Setyabudi F | 2007 | Poultry Science2007，86，1： | 1 |
| 11 | CYP4F2 genetic variant alters required warfarin dose显示文摘 | CALDWELL M D AWAD T JOHNSON J A | 2008 | Blood2008，111，8： | 1 |
| 12 | Effect of addition of a probiotic microorganism to broiler diets contaminated with deoxynivalenol on performance and histological alterations of intestinal villi of broiler chicken 显示文摘 | AWAD W A BOHM J RAZZAZI-FAZELI E | 2006 | Poultry Science2006，85，6： | 1 |
| 13 | β-sitosterol inhibits growth of HT-29 human colon cancer cells by activating the sphin-gomyelin cycle显示文摘 | Awad A B Von Holtz R L Cone J P | 1998 | Anticancer Res1998，18，： | 1 |
| 14 | Gastroenterol 显示文摘 | AWAD J A ROBERTS L J BURK R F | 1996 | Clin North Am1996，25，： | 1 |
| 15 | Chondrogenic differentiation of adipose-derived adult stem cells in agarose,alginate,and gelatin scaffolds显示文摘 | Awad H A Wickham M Q Leddy H A Gimble J M Guilak F | | 0，，： | 1 |
| 16 | Formation of novel non-cy-clooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetra- chloride hepatotoxicity显示文摘 | J D Morrow J A Awad T Kato | 1992 | J Clin Invest1992，90，： | 1 |
| 17 | Blastoeystis hominis as a cause of hypoalbuminemia and anasarea显示文摘 | Nassir E Awad J Abel A B | 2004 | Eur J Clin Micro- biol Inefeet Dis2004，23，5： | 1 |
| 18 | The increasing incidence and prevalence of female multiple sclerosis-a critical analysis of potential environmen-tal factors显示文摘 | Sellner J Kraus J Awad A | 2011 | Autoimmun Rev2011，10，： | 1 |
| 19 | Three-dimensional lung tumor segmentation from x-ray computed tomography using sparse field active models 显示文摘 | Awad J Owrangi A Villemaire L | 2012 | Medical physics2012，39，2： | 1 |
| 20 | Effects of feeding deoxynivalenol contaminated wheat on growth performance,organ weights and histological parameters of the intestine of broiler chickens显示文摘 | AWAD W A BOHM J RAZZAZI-FAZELI E | 2006 | Journal of Animal Physiology and Animal Nutrition2006，90，12： | 1 |
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