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| 1 | MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma显示文摘Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is be-coming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer. | Cameron M Smith David I Watson Michael Z Michael Damian J Hussey | 2010 | World Journal of Gastroenterology2010，16，5： | 23 |
| 2 | Management and prevention of acute and chronic lateral ankle instability in athletic patient populations显示文摘Acute and chronic lateral ankle instability are common in high-demand patient populations. If not managed appropriately, patients may experience recurrent instability, chronic pain, osteochondral lesions of the talus, premature osteoarthritis, and other significantlong-term disability. Certain populations, including young athletes, military personnel and those involved in frequent running, jumping, and cutting motions, are at increased risk. Proposed risk factors include prior ankle sprain, elevated body weight or body mass index, female gender, neuromuscular deficits, postural imbalance, foot/ankle malalignment, and exposure to at-risk athletic activity. Prompt, accurate diagnosis is crucial, and evidence-based, functional rehabilitation regimens have a proven track record in returning active patients to work and sport. When patients fail to improve with physical therapy and external bracing, multiple surgical techniques have been described with reliable results, including both anatomic and nonanatomic reconstructive methods. Anatomic repair of the lateral ligamentous complex remains the gold standard for recurrent ankle instability, and it effectively restores native ankle anatomy and joint kinematics while preserving physiologic ankle and subtalar motion. Further preventative measures may minimize the risk of ankle instability in athletic cohorts, including prophylactic bracing and combined neuromuscular and proprioceptive training programs. These interventions have demonstrated benefit in patients at heightened risk for lateral ankle sprain and allow active cohorts to return to full activity without adversely affecting athletic performance. | Brendan J Mc Criskin Kenneth L Cameron Justin D Orr Brian R Waterman | 2015 | World Journal of Orthopedics2015，6，2： | 20 |
| 3 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 4 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 5 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 8 |
| 6 | 脉压对颈动脉壁重构的影响——探讨Laplace定律对大血管重构的作用显示文摘目的:血管壁的增厚和功能指数正越来越多的被用作评价心血管疾病的重要指标。然而大血管的结构、功能、压力的相互关系在活体上还没有很好的确定。我们研究组对一组正常和高血压病人进行了大血管的结构-功能-压力的相互关系的交叉研究。方法:307例正常和高血压的人群被选择到此研究,其中男110例,女197例。年龄49~75岁。颈动脉内膜和中层厚度(Intima-media wall thickness,IMT)和内腔直径(Lumen diameter,LD)用Diasonic(DRF400)高分辨率超声来确定。血管壁环状压(Circumferential stress,Cs)是依据LAPLACE定律(δ=P×r/h)计算。其中压力(Pressure,P)用平均压和脉压两种方法计算。此动脉的结构和功能指数用年龄、身高和心率来校正。颈动脉压用无创压力感受器测定。结果:共有70例高血压(BP>140/90)患者。用年龄、身高和心率校正后的内中膜厚度和内腔直径在高血压组显著增加。而且IMT随着脉压的增大而增大(r=0.39,P<0.001)。内腔半径与内中膜厚度比值(R/IMT,R=LD/2)和环状压在高血压组明显增加。但是不管高血压或正常人群的R/IMT比值与脉压呈负相关关系(r=0.38,P<0.001),而与平均压无关。结论:在高血压状态下颈动脉壁重构是服从LAPLACE定律的,但颈动脉壁重构不足以抵销高血压状态下的血管壁环状压的增加。 | 梁雨露 Cameron J McGrath BP | 2002 | 中国医药导刊2002，4，1： | 4 |
| 7 | Bleeding outcomes after non-emergency percutaneous coronary intervention in the very elderly显示文摘BackgroundOctogenarians 组成病人为经皮的冠的干预(一种总线标准).MethodsThis 学习评估了的非紧急情况介绍的一个增加的比例在里面医院程序的特征和结果,包括为非紧急情况一种总线标准在 2010 年 1 月和 2012 年 12 月之间介绍给单个大体积的 293 octogenarians 的流血事件第三级的照顾澳大利亚人中心。比较被做, 293 个连续病人,其损害与心肌的梗塞是的 octogenarians.ResultsNon 圣举起被匹配小于等于 60 年变老为在 octogenarians 的非紧急情况一种总线标准的最经常的指示。比作更年轻的队,他们有合作病态和更复杂的冠的疾病的更高的流行,包括更多的类型 C 和钙化的损害。低分子的重量肝磷脂的仙子程序的使用(LMWH;1.0% 对 5.8% ;P < 0.001 ) 并且 glycoprotein IIb/IIIa 禁止者(2.1% 对 9.6% ;P < 0.001 ) 更低,当大腿骨的动脉的存取比在更年轻的病人更通常被使用时(80.9% 对 67.6% ;P < 0.001 ) 。总的来说,向所有流血事件在的更高的发生有一个不重要的趋势老(9.2% 对 5.8% ;P = 0.12 ) 。在存取地点或非存取地点流血和专业或在二个队之间的次要的流血没有重要差别。亚分析没在由 LMWH, glycoprotein IIb/IIIa 禁止者或大腿骨的动脉的存取的使用为率放血上揭示任何重要影响。另外,处于在二 groups.ConclusionsIn 之间的在里面医院死亡,击或尖锐 stent 血栓的率没有重要差别这单个中心研究,我们没包括在经历非紧急情况一种总线标准的 octogenarians 流血的发生在不利在里面医院结果观察重要增加。 | Vimalraj Bogana Shanmugam Dennis T Wong Hashrul Rashid James D Cameron Yuvaraj Malaiapan Peter J Psaltis | 2017 | Journal of Geriatric Cardiology2017，14，10： | 3 |
| 8 | Reuse of liver grafts following the brain death of the initial recipient显示文摘AIM: To determine if there is a reasonable prospect of success of a re-use liver transplantation.METHODS: We systematically searched for reports of liver graft re-use using electronic searches of PubMed and Web of Knowledge. We performed hand searches of references lists of articles reporting re-use of grafts.RESULTS: A systematic review of the literature reveals 28 liver transplantations using previously transplanted grafts. First and second recipients ranged in age from 4 to 72 years and 29 to 62 years respectively. Liver disease in the first recipient was varied including 5(18%) patients with fulminant liver failure who died subsequently of cerebral edema. The second transplanta-tion was performed after a median interval of 5 d(one day-13 years). Viral hepatitis was present in 3(11%) of the initial recipients and in 8(29%) of final recipients. Hepatocellular carcinoma was present in 6(21%) of the final recipients. Early survival after the final transplantation was 93%, whereas long-term survival was 78% with a mean follow-up of 23.3(3-120) mo.CONCLUSION: Outcomes of transplantation using previously transplanted grafts in this select population are similar to those seen with conventional grafts. | Hideaki Tanaka Vivian C McAlister Mark A Levstik Cameron N Ghent Paul J Marotta Douglas Quan William J Wall | 2014 | World Journal of Hepatology2014，6，6： | 3 |
| 9 | Advanced Synthesis Techniques for Microwave Filters显示文摘With the advent of the ‘digital revolution’ that has made possible services such as the world wide web, satellite broadcasting and mobile and trunk telephony, the finite RF spectrum allocated for terrestrial and satellite telecommunication systems is becoming increasingly crowded. This has impacted significantly upon the performance required from the microwave equipment that comprises these systems. In the case of microwave filters, greater in-band linearity to avoid signal distortion and out-of-band isolation to suppress interference are routinely specified, which can only be satisfied by advanced filtering characteristics. This article presents the coupling matrix approach to the synthesis of prototype filter networks, enabling the realization of the hardware embodying the enhanced performance needed by today’s high capacity systems. | Richard J Cameron | 2011 | ZTE Communications2011，9，2： | 2 |
| 10 | Recurrent calcium nephrolithiasis associated with primary aldosteronism 显示文摘 | Shey J Cameron M A Sakhaee K | 2004 | Am J Kidney Dis2004，44，1： | 1 |
| 11 | TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA显示文摘 | CHOCKALINGAM A BROOKS J C CAMERON J L | 2009 | Immunol Cell Biol2009，87，3： | 1 |
| 12 | Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including HSN1 avian influenza显示文摘 | Macdonald S J Cameron R Demaine D A | 2005 | J Med Chem2005，48，8： | 1 |
| 13 | Novel Cell Culture Device Enabling Three-Dimensional Cell Growth and hnproved Cell Function 显示文摘 | Bokhari M Camachan R J Cameron N R | 2007 | Biochem Biophys Res Comnmn2007，354，4： | 1 |
| 14 | Fast generation of Chebyshev filter prototypes with asymmetrically-prescribed transmission zeros显示文摘 | R J Cameron | 1982 | ESA J1982，6，： | 1 |
| 15 | One Thousand Consecutive Pancreaticoduodenectomies 显示文摘 | Cameron JL Raiall TS Caleman J | 2006 | Ann Surg2006，244，1： | 1 |
| 16 | Adenocarcinoma of the esophagogastric junction and Barrett's esophagus 显示文摘 | Cameron A J Lomboy CT Pera M | 1995 | Gastroenterology1995，109，5： | 1 |
| 17 | Murray river water,raised cyanobacterial counts and gastrointestinal and dermatological symptoms显示文摘 | El Saadi O Esterman A J Cameron S | 1995 | Medical Journal of Australia1995，162，： | 1 |
| 18 | A prospective randomized study of anterior cruciate ligament reconstruction:a comparison of patellar tendon and quadruple-strand semitendinosus/gracilis tendons fixed with bioabsorbable interference screws显示文摘 | Maletis G B Cameron S L Tengan J J | | 0，，03： | 1 |
| 19 | Advanced Coupling Matrix Synethesis Techniques for Microwave Filters显示文摘 | Cameron R J | | 0，，： | 1 |
| 20 | Calnexin phosphorylation:linking cytoplasmic signalling to endoplasmic reticulum lumenal functions显示文摘 | Chevet E Smirle J Cameron PH | 2010 | Semin Cell Dev Biol2010，21，5： | 1 |
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