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| 1 | Total pancreatectomy and islet autotransplantation: A decade nationwide analysis显示文摘AIM: To investigate outcomes and predictors of inhospital morbidity and mortality after total pancreatectomy(TP) and islet autotransplantation. METHODS: The nationwide inpatient sample(NIS) database was used to identify patients who underwent TP and islet autotransplantation(IAT) between 2002-2012 in the United States. Variables of interest were inherent variables of NIS database which included demographic data(age, sex, and race), comorbidities(such as diabetes mellitus, hypertension, and deficiency anemia), and admission type(elective vs nonelective). The primary endpoints were mortality and postoperative complications according to the ICD-9 diagnosis codes which were reported as the second to 25 th diagnosis of patients in the database. Risk adjusted analysis was performed to investigate morbidity predictors. Multivariate regression analysis was used to identify predictors of in-hospital morbidity.RESULTS: We evaluated a total of 923 patients who underwent IAT after pancreatectomy during 2002-2012. Among them, there were 754 patients who had TP + IAT. The most common indication ofsurgery was chronic pancreatitis(86%) followed by acute pancreatitis(12%). The number of patients undergoing TP + IAT annually significantly increased during the 11 years of study from 53 cases in 2002 to 155 cases in 2012. Overall mortality and morbidity of patients were 0% and 57.8 %, respectively. Postsurgical hypoinsulinemia was reported in 42.3% of patients, indicating that 57.7% of patients were insulin independent during hospitalization. Predictors of inhospital morbidity were obesity [adjusted odds ratio(AOR): 3.02, P = 0.01], fluid and electrolyte disorders(AOR: 2.71, P < 0.01), alcohol abuse(AOR: 2.63, P < 0.01), and weight loss(AOR: 2.43, P < 0.01). CONCLUSION: TP + IAT is a safe procedure with no mortality, acceptable morbidity, and achieved high rate of early insulin independence. Obesity is the most significant predictor of in-hospital morbidity. | Reza Fazlalizadeh Zhobin Moghadamyeghaneh Aram N Demirjian David K Imagawa Clarence E Foster Jonathan R Lakey Michael J Stamos Hirohito Ichii | 2016 | World Journal of Transplantation2016，6，1： | 9 |
| 2 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 3 | 相对于男性,女性进行冠状动脉造影产生的额外的心血管病风险与严重受损的冠状动脉血流储备,而非阻塞性疾病相关显示文摘与男性相比,女性的心血管病死亡率更高,但是阻塞性冠状动脉疾病(coronary artery disease,CAD)在女性中不太普遍。冠状动脉血流储备(coronary flow reserve,CFR)是大、小血管CAD和心肌缺血的综合测量指标,可识别出具有心血管病死亡风险的患者,但其在临床实践中不是常规测量的指标。该研究试图调查性别、CFR和血管造影CAD严重程度对不良心血管事件的影响。 | 刘莉 叶鹏 Taqueti VR Shaw LJ Cook NR Murthy VL Shah NR Foster CR Hainer J Blankstein R Dorbala S Di Carli MF | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 4 | Strength and Deformation of High-Strength Concrete Shearwalls显示文摘 | Farvashany Firooz Emamy Foster Stephen J Rangan B Vijaya | 2008 | ACI Structural Journal2008，，1： | 2 |
| 5 | Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias显示文摘 | Steven L Higgins John D Hummel Imran K Niazi Michael C Giudici Seth J Worley Leslie A Saxon John P Boehmer Michael B Higginbotham Teresa De Marco Elyse Foster Patrick G Yong | 2003 | Journal of the American College of Cardiology2003，，8： | 2 |
| 6 | Grid services, for distributed system integration显示文摘 | Foster I Kesselman C Nick J M | 2002 | Compute2002，35，6： | 1 |
| 7 | Grid services for distributed systems integration显示文摘 | FOSTER I KESSELMAN C NICK J | 2002 | IEEE Comput2002，35，6： | 1 |
| 8 | Regulation of calcium levels in brain tissue from adult and aged rats 显示文摘 | Michaelis M L Foster C T Jayawichreme C J | 2002 | Mechanisms of Ageing and Development2002，62，3： | 1 |
| 9 | Oxidation products formed from gaseous alkane by the bacterium Pseudomonas metharica 显示文摘 | Leadbetter E R Foster J W | 1959 | Arch Biochem Biophys1959，82，： | 1 |
| 10 | The 2-pebbling property and a conjecture of Graham's显示文摘 | Foster J A | 2000 | Graphs Combin2000，16，2： | 1 |
| 11 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 12 | Uhrasound biom- icroscopy of anterior segment structures in normal and glau-comatous eyes 显示文摘 | Pavlin C J Harasiewicz K Foster FS | 1992 | Am JOph thamol1992，113，： | 1 |
| 13 | Determination of optimal pacing strategy in track cycling with an energy flow model显示文摘 | DE KONING J J BOBBERT M F FOSTER C | 1992 | J Sci Med Sport1992，2，3： | 1 |
| 14 | The analytical foundations of evolutionary economics显示文摘 | Foster J | 1997 | Structural Change and Economic Dynamics1997，，8： | 1 |
| 15 | AIDS-related experience, knowledge, attitudes and beliefs amongst nurses in area with a high rate of HIV infection显示文摘 | Plant M L Foster J | 1993 | Journal of Advanced Nursing1993，18，： | 1 |
| 16 | Central corneal thickness and intraocular pressure in a Mongolian population显示文摘 | Foster PJ Bassanhu J Alsbirk PH | 1998 | Ophthalmology1998，105，： | 1 |
| 17 | The definition and classification of glaucoma in prevalence surveys 显示文摘 | FOSTER P J BUHRMANN R QUIGLEY H A | 2002 | Br J Ophthalmol2002，86，2： | 1 |
| 18 | Grid services for distributed system integration 显示文摘 | FOSTER I KESSELMAN C NICK J | 2002 | Computer2002，35，6： | 1 |
| 19 | The effect of various electrolyte additives on reversible Li-graphite intercalation显示文摘 | Foster D L Behl W K Wolfenstine J | 2000 | J Power Sources2000，85，2： | 1 |
| 20 | Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway显示文摘 | Foster J S Fernando R I Ishida N | 2003 | J Biol Chem2003，278，41： | 1 |
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