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| 1 | Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation显示文摘Liver transplantation(LT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma(HCC) who are not candidates for resection. When the Milan criteria are strictly applied, 75% to85%of 3-to 4-year actuarial survival rates are achieved, but up to 20% of the patients experience HCC recurrence after transplantation. The Milan criteria are based on the preoperative tumor macromorphology, tumor size and number on computed tomography or magnetic resonance imaging that neither correlate well with posttransplant histological study of the liver explant nor accurately predict HCC recurrence after LT, since they do not include objective measures of tumor biology. Preoperative biological markers, including alpha-fetoprotein, desgamma-carboxiprothrombin or neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio, can predict the risk for HCC recurrence after transplantation.These biomarkers have been proposed as surrogate markers of tumor differentiation and vascular invasion, with varied risk magnitudes depending on the defined cutoffs. Different studies have shown that the combination of one or several biomarkers integrated into prognostic models predict the risk of HCC recurrence after LT more accurately than Milan criteria alone. In this review, we focus on the potential utility of these serum biological markers to improve the performance of Milan criteria to identify patients at high risk of tumoral Published online: January 27, 2019 recurrence after LT.Liver transplantation(LT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma(HCC) who are not candidates for resection. When the Milan criteria are strictly applied, 75% to85%of 3-to 4-year actuarial survival rates are achieved, but up to 20% of the patients experience HCC recurrence after transplantation. The Milan criteria are based on the preoperative tumor macromorphology, tumor size and number on computed tomography or magnetic resonance imaging that neither correlate well with posttransplant histological study of the liver explant nor accurately predict HCC recurrence after LT, since they do not include objective measures of tumor biology. Preoperative biological markers, including alpha-fetoprotein, desgamma-carboxiprothrombin or neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio, can predict the risk for HCC recurrence after transplantation.These biomarkers have been proposed as surrogate markers of tumor differentiation and vascular invasion, with varied risk magnitudes depending on the defined cutoffs. Different studies have shown that the combination of one or several biomarkers integrated into prognostic models predict the risk of HCC recurrence after LT more accurately than Milan criteria alone. In this review, we focus on the potential utility of these serum biological markers to improve the performance of Milan criteria to identify patients at high risk of tumoral recurrence after LT. | Maria J Citores Jose L Lucena Sara de la Fuente Valentin Cuervas-Mons | 2019 | World Journal of Hepatology2019，11，1： | 12 |
| 2 | Differential adhesion of major surface proteins la and lb of the chrlichial cattle pathogen Anaplasma marginale to bovine erythrecytes and tick cells显示文摘 | DELA FUENTE J GARCIA -GARCIA J C BLOUIN E F | 2001 | Im J Parasitol2001，31，2： | 1 |
| 3 | Infection of tick cells and bovine erythroeytes with one genotype of the intracellular Ehrlichia Anaplasma marginale excludes infection with other genotypes显示文摘 | DE LA FUENTE J GARCIA-GARCIA J C BLOUIN E F | 2002 | Clin Diagn Lab Immunol2002，9，3： | 1 |
| 4 | Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy显示文摘 | Navarro-Gonzdlez J F Mora-Ferndndez C Muros de Fuentes M Garcia-Perez J | 2011 | Nat Rev Nephrol2011，7，： | 1 |
| 5 | Individual differences in the Behavioral Inhibition System are associated with orbitofrontal cortex and precuneus gray matter volume 显示文摘 | Fuentes P Barros-Loscertales A Bustamante J C | 2012 | Cogn Affect Behav Neurosci2012，12，3： | 1 |
| 6 | Biocide tolerance in bacteria 显示文摘 | Morente E O FernandezFuentes M A Burgos M J | 2013 | Int J Food Microbiol2013，162，1： | 1 |
| 7 | The usefulness of UV–visible and fluorescence spectroscopies to study the chemical nature of humic substances from soils and composts显示文摘 | Fuentes M González-Gaitano G García-Mina J M | 2006 | Organic Geochemistry2006，37，12： | 1 |
| 8 | Isomerization of lactose catalyzed by alkaline-substituted sepiolites显示文摘 | FUENTES M A J(A)REZ M RAFAEL D VILLAMIEL M OLANO A | | 0，，03： | 1 |
| 9 | Learners'attention to input during focus on form listening tasks:the role of mobile technology in the second language classroom显示文摘 | DE LA FUENTE M J | 2014 | Computer Assisted Language Learning2014，27，3： | 1 |
| 10 | Efficacy of intra-venous thrombolysis according to stroke subtypes: the Ma- drid Stroke Network data显示文摘 | FUENTES B EGIDO J SIMAL P | 2012 | Eur J Neurol2012，19，12： | 1 |
| 11 | Aroma volatile compounds of Fuji apples in relation to harvest date and cold storage technology: A comparison of two seasons显示文摘 | ECHEVERRIA G FUENTES T GRAELL J LARA I LOPEZ M L | 2004 | Postharvest Biology and Technology2004，32，： | 1 |
| 12 | Pectin esterase gene family in strawberry fruit:study of FaPE1, a ripening-specific isoform显示文摘 | Castillejo C de la Fuente J I Iannetta P | 2004 | J Exp Bot2004，55，398： | 1 |
| 13 | Compositional and structural changes during aerial oxidation of coal and their relations with technological properties 显示文摘 | Iglesias M J de la Puente G Fuente E | 1998 | Vibrational Spectroscopy1998，17，1： | 1 |
| 14 | Long-time observations of the atmospheric exchange of CO2 with a temperate deciduous forest in southern Ontario显示文摘 | LEE X FUENTES J D STAEBLEER R M | 1999 | Journal Canada of Geophysical Research1999，14，15： | 1 |
| 15 | Preparation of MoS2 and WS2 catalysts by in situ decomposition of ammonium thiosalts显示文摘 | Alonso G Del Valle M Cruz J Petranovskii V LiceaClaverie A Fuentes S | | 0，，： | 1 |
| 16 | Rituximab therapy in refractory neuropsychiatric lupus: current clinical evidence显示文摘 | NARVAEZ J RIOS-RODRIGUEZ V DE LA FUENTE D | 2011 | Semin Arthritis Rheum2011，41，3： | 1 |
| 17 | DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children 显示文摘 | Pérez-Maldonado IN D??az-Barriga F de la Fuente H González-Amaro R Calderón J Yá?ez L | 2004 | Environ Res2004，94，1： | 1 |
| 18 | Strategies for development of vaccines for control of ixodid tick species显示文摘 | de la Fuente J K.M.Kocan | | 0，，07： | 1 |
| 19 | Tellurite: history, oxidative stress, and molecular mechanisms of resistance显示文摘 | Chasteen T G Fuentes D E Tantalean J C | 2009 | FEMS Microbiol Rev2009，33，4： | 1 |
| 20 | Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells 显示文摘 | Zaba L C Fuentes D J Eungdamrong N J | 2009 | J Invest Dermatol2009，129，1： | 1 |
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