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| 1 | Molecular genetics and genomics of the Rosoideae: state of theart and future perspectives显示文摘The Rosoideae is a subfamily of the Rosaceae that contains a number of species of economic importance,including the soft fruit species strawberry(Fragaria 3ananassa),red(Rubus idaeus)and black(Rubus occidentalis)raspberries,blackberries(Rubus spp.)and one of the most economically important cut flower genera,the roses(Rosa spp.).Molecular genetics and genomics resources for the Rosoideae have developed rapidly over the past two decades,beginning with the development and application of a number of molecular marker types including restriction fragment length polymorphisms,amplified fragment length polymorphisms and microsatellites,and culminating in the recent publication of the genome sequence of the woodland strawberry,Fragaria vesca,and the development of high throughput single nucleotide polymorphism(SNP)-genotyping resources for Fragaria,Rosa and Rubus.These tools have been used to identify genes and other functional elements that control traits of economic importance,to study the evolution of plant genome structure within the subfamily,and are beginning to facilitate genomic-assisted breeding through the development and deployment of markers linked to traits such as aspects of fruit quality,disease resistance and the timing of flowering.In this review,we report on the developments that have been made over the last 20 years in the field of molecular genetics and structural genomics within the Rosoideae,comment on how the knowledge gained will improve the efficiency of cultivar development and discuss how these advances will enhance our understanding of the biological processes determining agronomically important traits in all Rosoideae species. | Sara Longhi Lara Giongo Matteo Buti Nada Surbanovski Roberto Viola Riccardo Velasco Judson AWard Daniel J Sargent | 2014 | Horticulture Research2014，1，1： | 7 |
| 2 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 3 | The role of squamous cell carcinoma antigen in the management of laryngeal and hypopharyngeal cancer显示文摘 | Lara P C Cuyas J M | 1995 | Cancer1995，76，5： | 1 |
| 4 | Activity of high-dose toremifene plus cisplatin in platinum-treated non-small-cell lung cancer: a phase Ⅱ California Cancer Consortium Trial显示文摘 | Lara PN Jr Gandara DR Longmate J | 2001 | Cancer Chemother Pharmacol2001，48，1： | 1 |
| 5 | Involvement of the S-layer proteins Hpi and S1pA in the maintenance of cell integrity in Deinococcns radiodnrans Rl显示文摘 | Rotlifnss H Lara J C Sclnnid A K | 2006 | Microbiology2006，152，9： | 1 |
| 6 | The proteosome inhibitor PS-341 (Bortezomib) in platinum (plat)-treated extensive stage small cell lung cancer (E-SCLC):A SWOG (0327)phase Ⅱ trial显示文摘 | Johl J Chansky K Lara PN | 2005 | Proc Am Soc Clin Oncol2005，，： | 1 |
| 7 | Black liquor lignin biodegradation by Trametes elegans 显示文摘 | Lara M A R M Antonio J R Orlando J | 2003 | Intemation Biodeterioration & Biodegradation2003，52，3： | 1 |
| 8 | Phase Ⅱ trial of irinote-ean/cisplatin compared with etoposide/cisplatin in extersive-stage small-cen lung cancer:clinical and pharmarogenomic results from SWOG SO124 显示文摘 | Lara P N Jr Natale R Crouley J | 2009 | J Clin Onco12009，27，15： | 1 |
| 9 | Phase Ⅲ trial of irinotecan/cisplatin compared with etoposide/cisplatin in extensive-stage small-cell lung cancer:clinical and pharmacogenomic results from SWOGS0124显示文摘 | Lara PN Jr Natale R Crowley J | 2009 | J Clin Oncol2009，27，15： | 1 |
| 10 | Quaternary nannofossil biostratigraphy from ocean drilling program leg 189,Tasmanian Gateway显示文摘 | Stant S A Lara J McGonigal K L | | 0，，： | 1 |
| 11 | Passivation of the calcite surface with malonate ion 显示文摘 | Salinas-Nolasco M F Mendez-Vivar J Lara V H | 2004 | Journal of Colloid and Interface Science2004，274，1： | 1 |
| 12 | In vivo suppression of precore mRNA synthesis is associated with mutations in the hepatitis B virus core promoter显示文摘 | Laras A Koskinas J Hadziyannis SJ | 2002 | Virology2002，295，： | 1 |
| 13 | Aroma volatile compounds of Fuji apples in relation to harvest date and cold storage technology: A comparison of two seasons显示文摘 | ECHEVERRIA G FUENTES T GRAELL J LARA I LOPEZ M L | 2004 | Postharvest Biology and Technology2004，32，： | 1 |
| 14 | Numerical analysis of wave overtopping of rubble mound breakwaters显示文摘 | Losada I J Lara J L Guanchea R Gonzalez-Ondina J M | 2008 | Coastal Engineering2008，55，1： | 1 |
| 15 | Two-level evolution of foraging agent communities显示文摘 | ALFONSECA M LARA J | 2002 | BioSystems2002，66，： | 1 |
| 16 | Accounting Conservatism and Corporate Governance 显示文摘 | Lara J Osma B Penalva F | 2009 | Review of Accounting Studies2009，14，1： | 1 |
| 17 | Periodic solutions in electrodynamic tethers on inclined orbits显示文摘 | Pelfiez J Lara M | | 0，，： | 1 |
| 18 | A comparison of pal iative stenting or emergent surgery for obstructing incurable colon cancer显示文摘 | Vemulapal i R Lara LF Sreenarasimhaiah J | | 0，，10： | 1 |
| 19 | Clean recovery of antioxidant flavonoids from citrus peel:optimizing an aqueous ultrasound-assisted extraction method显示文摘 | Londono-Londono J Delima VR Lara O | | 0，，01： | 1 |
| 20 | Effects of exercise modalities on arterial stiffness and wave refleetiom a systematic review and meta-analysis of randomized controlled trials显示文摘 | Ashor AW Lara J Siervo M | 2014 | PLoS 0ne2014，9，11： | 1 |
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