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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | The role of squamous cell carcinoma antigen in the management of laryngeal and hypopharyngeal cancer显示文摘 | Lara P C Cuyas J M | 1995 | Cancer1995，76，5： | 1 |
| 3 | Mamey sapote cultivars in Florida显示文摘 | Campbell C W S P Lara | 1982 | Processdings of the Florida State Horticultural Society1982，95，： | 1 |
| 4 | 显示文摘 | Lara Wilfredo C Jeremy S Lewis Rodney P | 1998 | Journal of Long-Term Effects of Medical Implants1998，8，1： | 1 |
| 5 | A simple method for real-time DSP-based neutron-chopper speed and phase control显示文摘 | ROSE C R LARA P D NELSON R O | 2001 | Proceedings of the Particle Accelera- tor Conference2001，，： | 1 |
| 6 | Social and spatial relation- ships in captive southern white rhinoceros(Ceratotherium simum)显示文摘 | Lara C Linda M P George H W | 2007 | Zoo Biology2007，26，6： | 1 |
| 7 | The rpoN gene product of Pseudo-monas aeruginosa is required for expression of diverse genes,inclu-ding the flagellin gene显示文摘 | Totten P A Lara J C Lory S | | 0，，01： | 1 |
| 8 | Phosphorus stress in common bean: root transcript and metabolic, responses 显示文摘 | Hern6ndez G Ramirez M Valdes-L6pez O Tesfaye M Graham M A Czechowski T Schlereth A Wandrey M Erban A Cheung F Wu H C Lara M Town C D Kopka J Udvardi M K Vance C P | 2007 | Plant Physiol2007，144，： | 1 |
| 9 | Changes in the oral environment during four stages of orthodontic treatment显示文摘 | Lara C E Normam M Leonor S P | 2010 | Korean J Orthod2010，40，2： | 1 |
| 10 | Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer显示文摘 | Petrylak D P Tangen C M Hussain M H Lara P N Jr Jones J A Taplin M E | 2004 | N Engl J Med2004，351，： | 1 |
| 11 | Social and spatial relationships in captive southern white rhinoceros( Ceratotherium simum simum ) 显示文摘 | Lara C Linda M P George H W | 2007 | Zoo Biology2007，26，6： | 1 |
| 12 | Beyond antiepidermal growth factor receptors and antiangiogenesis strategies for non-small cell lung cancer:exploring a new frontier显示文摘 | SANGHA R LARA P N Jr MACK P C | 2009 | Curr Opin Oncol2009，21，2： | 1 |
| 13 | Relaxation of nutrient requirements on livestock rations through interactive multigoal programming显示文摘 | LARA P ROMERO C | 1994 | Agricultural Systems1994，45，4： | 1 |
| 14 | Role of CD4 and CD8 T-lymphoeytes, B-lymphocytes and natural killer cells in the prediction of radiation-induced late toxicity in cervical cancer patients 显示文摘 | Bordon E Henriquez-Hemandez L A Lara P C | 2011 | Int J Radiat Biol2011，87，4： | 1 |
| 15 | Multicriteria fractional model for feed formulation : economic, nutritional and environmental criteria显示文摘 | CASTRODEZA C LARA P PEI'7 IA T | 2005 | Agricultural Systems2005，86，1： | 1 |
| 16 | Sorafenih with interferon alfa-2b as first line treatment of advanced renal carcinoma: a phase lI study of the Southwest Oncology Group 显示文摘 | Ryan C W Goldman B H Lara P N Jr Mack P C Beer T M Tangen C M | 2007 | J Clin Oncol2007，25，： | 1 |
| 17 | Plasmino- gen activator inhibitor-l(PAI-1)expression in relation to hypoxia and oncoproteins in clinical cervical tumors 显示文摘 | LARA P C Lloret M VALENCIANO A | 2012 | Strahlenther Onkol2012，188，12： | 1 |
| 18 | Uremic malnutrition is a predictorof death independent of inflammation status 显示文摘 | Kayser C Raymond H | 2004 | Kidney Int2004，66，： | 1 |
| 19 | Craniomaxillofacial features in hereditary mul-tiple exostosis显示文摘 | Ruiz L P Lara J C | 2012 | Craniofac Surg2012，23，4： | 1 |
| 20 | Role of CD4 and CD8 T-lymphocytes,B-lymphocytes and Natural Killer cells in the prediction of radiation-induced late toxicity in cervical cancer patients显示文摘 | Bord6n E Henríquez-Hernández L A Lara P C | | 0，，04： | 1 |
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