|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 肌萎缩性侧索硬化蛋白激活小胶质细胞NLRP3炎性小体显示文摘小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS)的SOD1G93A模型中,半胱天冬酶-1和IL-1β均促进疾病进展,提示小胶质NLRP3在该进程中发挥作用。然而先前的研究表明,SOD1G93A小鼠小胶质细胞不表达NLRP3,SOD1G93A蛋白在小胶质细胞中产生独立于NLRP3的IL-1β。本研究论证了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。本研究显示聚集和可溶性SOD1G93A均可激活小鼠原代小胶质细胞中的炎性小体,导致半胱天冬酶-1和IL-1β裂解,ASC斑点形成以及呈剂量和时间依赖性的IL-1β分泌。重要的是,SOD1G93A无法从缺乏Nlrp3的小胶质细胞或者用特异性NLRP3抑制剂MCC950预处理的小胶质细胞中诱导IL-1β分泌,从而证实NLRP3是介导SOD1诱导的小胶质细胞IL-1β分泌的关键炎症小体复合物。在TDP-43Q331K ALS小鼠模型中也观察到小胶质NLRP3上调,TDP-43野生型和突变蛋白亦可以NLRP3依赖性的方式激活小胶质炎性小体。从机制上讲,本研究确定了活性氧簇和ATP的生成是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,而病理ALS蛋白激活小胶质NLRP3炎性小体。因此,NLRP3抑制可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。 | Vandana Deora John D Lee Eduardo AAlbornoz Luke McAlary Cyril J Jagaraj Avril A B Robertson Julie D Atkin Matthew A Cooper Kate Schroder Justin J Yerbury Richard Gordon Trent MWoodruff 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，9： | 13 |
| 2 | Return to sport following tibial plateau fractures: A systematic review显示文摘AIM To systemically review all studies reporting return to sport following tibial plateau fracture, in order to provide information on return rates and times to sport, and to assess variations in sporting outcome for different treatment methods.METHODS A systematic search of CINAHAL, Cochrane, EMBASE, Google Scholar, MEDLINE, PEDro, Scopus, SPORTDiscus and Web of Science was performed in January 2017 using the keywords 'tibial', 'plateau', 'fractures', 'knee', 'athletes', 'sports', 'non-operative', 'conservative', 'operative', 'return to sport'. All studies which recorded return rates and times to sport following tibial plateau fractures were included. RESULTS Twenty-seven studies were included: 1 was a randomised controlled trial, 7 were prospective cohort studies, 16 were retrospective cohort studies, 3 were case series. One study reported on the outcome of conservative management(n = 3); 27 reported on the outcome of surgical management(n = 917). Nine studies reported on Open Reduction Internal Fixation(ORIF)(n = 193), 11 on Arthroscopic-Assisted Reduction Internal Fixation(ARIF)(n = 253) and 7 on Frame-Assisted Fixation(FRAME)(n = 262). All studies recorded 'return to sport'rates. Only one study recorded a 'return to sport' time. The return rate to sport for the total cohort was 70%. For the conservatively-managed fractures, the return rate was 100%. For the surgically-managed fractures, the return rate was 70%. For fractures managed with ORIF, the return rate was 60%. For fractures managed with ARIF, the return rate was 83%. For fractures managed with FRAME was 52%. The return rate for ARIF was found to be significantly greater than that for ORIF(OR 3.22, 95%CI: 2.09-4.97, P < 0.001) and for FRAME(OR 4.33, 95%CI: 2.89-6.50, P < 0.001). No difference was found between the return rates for ORIF and FRAME(OR 1.35, 95%CI: 0.92-1.96, P = 0.122). The recorded return time was 6.9 mo(median), from a study reporting on ORIF.CONCLUSION Return rates to sport for tibial plateau fractures remain limited compared to other fractures. ARIF provides the best return rates. There is limited data regarding return times to sport. Further research is required to determine return times to sport, and to improve return rates to sport, through treatment and rehabilitation optimisation. | Greg A J Robertson Seng J Wong Alexander M Wood | 2017 | World Journal of Orthopedics2017，8，7： | 10 |
| 3 | Lower limb stress fractures in sport:Optimising their management and outcome显示文摘Stress fractures in sport are becoming increasing more common,comprising up to 10%of all of sporting injuries.Around 90%of such injuries are located in the lower limb.This articles aims to define the optimal management of lower limb stress fractures in the athlete,with a view to maximise return rates and minimise return times to sport.Treatment planning of this condition is specific to the location of the injury.However,there remains a clear division of stress fractures by'high'and'low'risk.'Low risk'stress fractures are those with a low probability of fracture propagation,delayed union,or non-union,and so can be managed reliably with rest and exercise limitation.These include stress fractures of the PosteroMedial Tibial Diaphysis,Metatarsal Shafts,Distal Fibula,Medial Femoral Neck,Femoral Shaft and Calcaneus.'High risk'stress fractures,in contrast,have increased rates of fracture propagation,displacement,delayed and non-union,and so require immediate cessation of activity,with orthopaedic referral,to assess the need for surgical intervention.These include stress fractures of the Anterior Tibial Diaphysis,Fifth Metatarsal Base,Medial Malleolus,Lateral Femoral Neck,Tarsal Navicular and Great Toe Sesamoids.In order to establish the optimal methods for managing these injuries,we present and review the current evidence which guides the treatment of stress fractures in athletes.From this,we note an increased role for surgical management of certain high risk stress fractures to improve return times and rates to sport.Following this,key recommendations are provided for the management of the common stress fracture types seen in the athlete.Five case reports are also presented to illustrate the application of sportfocussed lower limb stress fracture treatment in the clinical setting. | Greg A J Robertson Alexander M Wood | 2017 | World Journal of Orthopedics2017，8，3： | 7 |
| 4 | 中国农村地区居民蔬菜的纤维含量和摄入状况的研究显示文摘目的了解中国不同地区农村居民主要摄入的蔬菜类食物的膳食纤维含量分布特点。方法利用1983年的全国65个县生态学调查资料,整理农村居民主要摄入的蔬菜类食物的膳食纤维数据,用均值和标准差来表达不同食物的膳食纤维含量值。按照国务院'十一五'规划中全国8个区域的划分设计,用方差分析和组间两两比较的Q检验分析同一种蔬菜膳食纤维含量在不同地区间的差异。结果不同蔬菜类食物的消费在全国的分布是不同的,其中只有萝卜、芸豆、茄子、红辣椒、南瓜、萝卜缨、油菜、大白菜、圆白菜、芹菜和韭菜的食用范围在全国分布较广,其它蔬菜类则仅限于部分地区食用。各种食物中膳食纤维和/或其单体的含量分布也存在不均衡的现象,其中萝卜、芸豆、红辣椒、南瓜、葫芦、圆白菜、甜土豆叶、菠菜和韭菜的纤维或其单体的含量在不同地区间存在明显差异(P<0.01,P<0.05)。用该数据对中国农村居民1982、1992和2002年的营养调查数据进行分析评价,农村居民每标准人日通过蔬菜类食物的膳食纤维摄入量随时间而降低,分别占AI值的32.7%、32.2%和29.7%。结论不同蔬菜类食物的消费在全国的分布是不平衡的,且其膳食纤维含量在不同地区间存在显著差异。 | 杨月欣 何梅 王光亚 Robertson J VanSoest P 陈君石 | 2007 | 卫生研究2007，36，6： | 6 |
| 5 | All-optical neuromorphic binary convolution with a spiking VCSEL neuron for image gradient magnitudes显示文摘All-optical binary convolution with a photonic spiking vertical-cavity surface-emitting laser(VCSEL) neuron is proposed and demonstrated experimentally for the first time, to the best of our knowledge. Optical inputs, extracted from digital images and temporally encoded using rectangular pulses, are injected in the VCSEL neuron,which delivers the convolution result in the number of fast(<100 ps long) spikes fired. Experimental and numerical results show that binary convolution is achieved successfully with a single spiking VCSEL neuron and that alloptical binary convolution can be used to calculate image gradient magnitudes to detect edge features and separate vertical and horizontal components in source images. We also show that this all-optical spiking binary convolution system is robust to noise and can operate with high-resolution images. Additionally, the proposed system offers important advantages such as ultrafast speed, high-energy efficiency, and simple hardware implementation,highlighting the potentials of spiking photonic VCSEL neurons for high-speed neuromorphic image processing systems and future photonic spiking convolutional neural networks. | YAHUI ZHANG JOSHUA ROBERTSON SHUIYING XIANG MATĚJ HEJDA JULIÁN BUENO ANTONIO HURTADO | 2021 | Photonics Research2021，9，5： | 4 |
| 6 | Upper gastrointestinal bleeding in Scotland 2000-2010: Improved outcomes but a significant weekend effect显示文摘AIM: To assess numbers and case fatality of patients with upper gastrointestinal bleeding(UGIB),effects of deprivation and whether weekend presentation affected outcomes.METHODS: Data was obtained from Information Services Division(ISD) Scotland and National Records of Scotland(NRS) death records for a ten year period between 2000-2001 and 2009-2010. We obtained data from the ISD Scottish Morbidity Records(SMR01) database which holds data on inpatient and daycase hospital discharges from non-obstetric and nonpsychiatric hospitals in Scotland. The mortality data was obtained from NRS and linked with the ISD SMR01 database to obtain 30-d case fatality. We used 23 ICD-10(International Classification of diseases) codes which identify UGIB to interrogate database. We analysed these data for trends in number of hospital admissions with UGIB,30-d mortality over time and assessed effects of social deprivation. We compared weekend and weekday admissions for differences in 30-d mortality and length of hospital stay. We determined comorbidities for each admission to establish if comorbidities contributed to patient outcome. RESULTS: A total of 60643 Scottish residents were admitted with UGIH during January,2000 and October,2009. There was no significant change in annual number of admissions over time,but there was a statistically significant reduction in 30-d case fatality from 10.3% to 8.8%(P < 0.001) over these 10 years. Number of admissions with UGIB was higher for the patients from most deprived category(P < 0.05),although case fatality was higher for the patients from the least deprived category(P < 0.05). There was no statistically significant change in this trend between 2000/01-2009/10. Patients admitted with UGIB at weekends had higher 30-d case fatality compared with those admitted on weekdays(P < 0.001). Thirty day mortality remained significantly higher for patients admitted with UGIB at weekends after adjusting for comorbidities. Length of hospital stay was also higher overall for patients admitted at the weekend when compared to weekdays,although only reached statistical significance for the last year of study 2009/10(P < 0.0005). CONCLUSION: Despite reduction in mortality for UGIB in Scotland during 2000-2010,weekend admissions show a consistently higher mortality and greater lengths of stay compared with weekdays. | Asma Ahmed Matthew Armstrong Ishbel Robertson Allan John Morris Oliver Blatchford Adrian J Stanley | 2015 | World Journal of Gastroenterology2015，21，38： | 4 |
| 7 | In vivo lung lavage as an experimental model of the respiratory distress syndrome 显示文摘 | Lachmann B Robertson B Vogel J | 1980 | Acta Anaesthesiol Scand1980，24，3： | 2 |
| 8 | Structural changes in the haemagglutinin which accompany egg adaptation of an influenza A(H1 N1 ) virus显示文摘 | Robertson J S Bootman J S Newman R | 1987 | Virology1987，160，1： | 2 |
| 9 | A comparison of size seleetion of haddock and whiting by square and diamond mesh codends显示文摘 | Robertson J H Stewart P A | 1988 | J Cons Int Expl Mer1988，44，： | 2 |
| 10 | Glucose toxicity in β - ceils: type 2 diabetes, good radicals gone bad, and the glutathionc connection 显示文摘 | Robertson RP Harmon J Tran PO | 2003 | Diabetes2003，52，： | 1 |
| 11 | Symposium:carbohudrate methodology,metabolism,and nutritional implications in dairy cattle:Methods for dietary fibre,neutral detergent fibre,and nonstarch polysaccharides in relation to animal nutrition显示文摘 | Van Scest P J Robertson J B Lewis B A | 1991 | Journal of Dairy Science1991，74，10： | 1 |
| 12 | Destruction of cyanobacterial toxins by semiconductor photocatalysis显示文摘 | ROBERTSON P K J LAWTON L A MANCH B | 1997 | Chem Commun1997，，4： | 1 |
| 13 | Role of insulin-like growth factors in embryonic and postnatal growth显示文摘 | Liu J P Robertson E J | 1993 | Cell1993，75，： | 1 |
| 14 | Lung infections:role of apoptosis in host defense and pathogenesis of disease显示文摘 | Behnia M Robertson KA Martin W J 2nd | 2000 | Chest2000，117，6： | 1 |
| 15 | Simultaneous nitrification and denitrification in aerobic chemostat culture of Thiosphaera patotropha显示文摘 | ROBERTSON L A VAN NIEL E W J TORREMANS R A M | 1988 | Applied Environmental Microbiology1988，54，11： | 1 |
| 16 | Precision determination of lattice parameters and coefficients of thermal expansion of BiFeO3显示文摘 | Bucci J D Robertson B K James W J | 1972 | J Appl Cryst1972，5，： | 1 |
| 17 | Survival following hepatic resection of colorectal cancer metastases: a national experience 显示文摘 | Robertson D J Stukel TA Gottlieb D J | 2009 | Cancer2009，115，4： | 1 |
| 18 | Effect of atorvastatin on kidney function in chronic kidney disease: a randomised double-blind placebo-controlled trial显示文摘 | Fassett R G Robertson I K Ball M J | 2010 | Atherosclerosis2010，213，1： | 1 |
| 19 | Phosphate plume persistence at two decommissioned septic system sites显示文摘 | Robertson W D Harman J | 1999 | Ground Water1999，37，22： | 1 |
| 20 | Preservation of giardia cysts in stool samples for subsequent PCR analysis 显示文摘 | HANS W ROBERTSON L J | 2009 | Journal of Microbiological Methods2009，，78： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员