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| 1 | 利用变形河流阶地限定帕米尔北缘木什背斜的缩短、隆升和侧向扩展显示文摘位于帕米尔前缘逆冲推覆体(Pamir Front Thrust,PFT)东端的木什滑脱背斜,是帕米尔弧形推覆构造带最前缘和最新的变形带。对地形横剖面、纵剖面和水系发育特征的分析表明,木什背斜总体上具有由西向东扩展生长的特征。在背斜核部及北翼发育数级开阔平坦的沿轴向展布的河流阶地,阶地可划分为4期。利用阶地堆积细颗粒石英光释光测年获得阶地面T2a、T3和T4的形成年龄分别为(15.8±2.40)ka、(55.1±10.3)ka、(131.4±23.9)ka。伴随背斜的生长扩展,河流阶地面发生了横向和纵向掀斜,并形成断层陡坎和褶皱陡坎。木什背斜晚第四纪的缩短和隆升主要是通过褶皱翼旋转机制进行的,估算其最小缩短速率为(1.6±0.3)mm/a,最小隆升速率为(1.9±0.3)mm/a。与此同时,沿轴向背斜发生了向东的侧向迁移和旋转。根据背斜垂直隆升与侧向扩展之间的关系,估算背斜在131~16ka期间向东的侧向迁移扩展速率较快,为(14.6±3.6)mm/a;自16ka至今,侧向迁移扩展速率迅速减小至(1.7±0.3)mm/a,背斜向东的迁移扩展可能已基本停止,而以侧向旋转为主。 | 李涛 陈杰 肖伟鹏 Burbank D W 黄明达 Thompson J | 2011 | 地震地质2011，33，2： | 21 |
| 2 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 3 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 4 | 西南天山前缘乌拉根背斜南翼逆断层的发现及其地质意义显示文摘塔里木盆地新疆喀什以西部分是西南天山和帕米尔两大对冲构造系统的会聚带,关于两者变形前缘和分界的确切位置存在不同认识。在乌恰县以南的玛依卡克盆地南缘,清晰可见属于帕米尔构造带、向N或NNE逆冲的帕米尔前缘逆冲推覆体(PFT)。最近野外调查在盆地北部发现了西南天山前缘的最新变形带:向南逆冲的乌拉根背斜南翼断层。断层总体近EW走向,在克孜勒苏河南岸和别尔托阔依河两岸河流阶地上形成了长约12km、坡向南的逆断坎,近地表断层产状为6°∠15°。由于乌拉根背斜及其南翼断层的活动,断层上盘阶地面上形成了多条弯滑断层,并发生了明显的反向掀斜。高阶地形成以来(区域对比表明,该阶地与木什背斜北翼T2大致为同一期阶地,其光释光年龄约为16ka),西南天山南缘吸收的总缩短量约71.4km,平均缩短速率约4.5mm/a。 | 李涛 陈杰 肖伟鹏 Burbank D W Thompson J 杨晓东 | 2011 | 地震地质2011，33，2： | 8 |
| 5 | 轮轨噪声预测模型研究进展显示文摘从轮对振动声辐射预测模型、轨道结构振动声辐射预测模型与轮轨相互作用预测模型等方面,总结了轮轨噪声预测模型的研究进展,阐述了主要的建模方法及其特点,给出了一些典型结果,并提出了需要进一步研究的问题。研究结果表明:在建立轮对在给定简谐轮轨力作用下的振动声辐射预测模型时,可以将轮对简化为轴对称弹性体,轮对的振动响应通过一个2维的结构有限元模型来预测,而它的声辐射则通过一个2维的声学边界元模型来确定,这样的建模方法可以全面且方便地考虑轮对旋转所带来的陀螺效应和移动荷载效应;在建立轨道结构在给定的简谐轮轨力作用下的振动声辐射预测模型时,可以将轨道结构简化为无限长周期结构,轨道结构的振动响应通过周期结构理论来分析,而它的声辐射则应用2.5维声学边界元来预测,这样的建模方法可以方便地考虑轮轨力沿轨道的高速移动并大大简化声辐射的计算;在建立轮轨相互作用预测模型时,可以利用轮对和钢轨在轮轨接触点处的频率响应函数或脉冲响应函数,这样的建模方法只以轮轨力为未知量,不但使得相应的微分方程或积分方程未知量少,而且完全考虑了轮对的旋转及沿轨道的移动;轮轨噪声预测还需研究的问题包括高速列车轮对的声辐射、高速轨道相对车体的声辐射、地下铁路轮轨噪声,以及包含降噪措施的轮轨噪声预测模型等。 | 圣小珍 成功 THOMPSON D J 葛帅 | 2021 | 交通运输工程学报2021，21，3： | 8 |
| 6 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 7 | Targeting collagen expression in alcoholic liver disease显示文摘Alcoholic liver disease(ALD)is a leading cause of liver disease and liver-related deaths globally,particularly in developed nations.Liver fibrosis is a consequence of ALD and other chronic liver insults,which can progress to cirrhosis and hepatocellular carcinoma if left un-treated.Liver fibrosis is characterized by accumulation of excess extracellular matrix components,including typeⅠcollagen,which disrupts liver microcirculation and leads to injury.To date,there is no therapy for the treatment of liver fibrosis;thus treatments that either prevent the accumulation of typeⅠcollagen or hasten its degradation are desirable.The focus of this review is to examine the regulation of typeⅠcollagen in fibrogenic cells of the liver and to discuss current advances in therapeutics to eliminate excessive collagen deposition. | Kyle J Thompson Iain H McKillop Laura W Schrum | 2011 | World Journal of Gastroenterology2011，17，20： | 7 |
| 8 | 澳大利亚肉类标准和分级体系显示文摘澳大利亚肉类标准(meat standards Australia,MSA)是一个肉类全面质量管理系统,旨在为消费者提供一个肉类食用品质的准确描述。MSA已经通过对消费者进行大规模的品尝实验,确定了牛肉供应链中影响牛肉可口性的生产、屠宰、加工和价值以及各个生产环节的关键控制点(critical control points,CCPs)评分。这些关键控制点评分通过两种方式管理牛肉的可口性。首先,屠宰加工领域的关键控制点一直作为胴体评分的强制性标准;其次,其他生产和加工领域的关键点控制评分被合并到一个模型当中,用来预测不同个体肌肉和烹饪技巧的可口性。MSA模型可以用来支持新的营销创新。已经有充分的证据表明,消费者愿意为优质牛肉付出高价。目前已出现几个零售的例子采用MSA可口性评分来给牛肉定价。这样胴体价值的计算方法即为每块零售肉质量乘以不同质量评分的价格,并按照零售价的比例支付牛肉生产者。该系统可以用不同的胴体性状相关的经济权重来计算。由于等级是基于持续的质量规模,生产者在这个系统中的质量和产量方面即便小有增加,也会获得相应的经济回报。MSA系统已经支撑了一个新的和创新的营销系统,该系统的定价是透明的,可以帮助生产者对肉品的质量和产量的调整作出明智的决定。MSA系统不仅在澳大利亚有效地用于预测牛肉的可口性,而且在其他国家也都证明了其应用的有效性。在欧洲启动的ProSafeBeef项目也表明,欧洲也可用类似MSA的系统进行肉类的分级。 | R POLKINGHORNE J M THOMPSON J F HOCQUETTE D W PETHICK 霍云龙 孟庆祥 | 2015 | 肉类研究2015，29，2： | 6 |
| 9 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 10 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 5 |
| 11 | Ionotropic receptors and ion channels in ischemic neuronal death and dysfunction显示文摘到神经原的精力供应的损失在击期间导致被称为缺氧的去极的膜潜力的快速的损失。因为离子的流动的 dysregulation 和 ATP 的损失,缺氧的去极在神经原上导致巨大的生理的应力驾驶维持电气化学的坡度的离子泵。在这评论,我们在场一些被认为贡献神经原并且随后的缺氧的去极的 ionotropic 受体和离子隧道的概述,到房间死亡。为作为门 ligand 的阳离子隧道工作的 glutamate 和 ATP 的 ionotropic 受体在神经原的死亡和机能障碍是批评的。有趣地,二这些受体(P2X7 和 NMDAR ) 被显示了联合离子隧道到 pannexin-1 (Panx1 ) 。我们也讨论短暂受体潜力(TRP ) 的重要角色响应局部缺血的隧道和酸察觉到的离子隧道(ASIC ) 。从我们缺氧的去极的当前的理解出现的中央挑战是需要阐明这些离子隧道到的机械学、时间的相互关系充分在击期间在神经原上欣赏他们的影响。 | Nicholas L WEILINGER Valentyna MASLIEIEVA Jennifer BIALECKI Sarup S SRIDHARAN Peter L TANG Roger J THOMPSON | 2013 | Acta Pharmacologica Sinica2013，34，1： | 5 |
| 12 | 帕米尔北缘木什背斜第四纪滑脱褶皱作用与北翼逆断裂的生长显示文摘发育在帕米尔弧形推覆构造带最前缘的木什活动背斜是一南缓北陡的第四纪滑脱褶皱,背斜的最小地壳缩短量为0.7km,构造隆升幅度可达1.5km。木什背斜北翼逆断层由一系列坡向北的反向断层陡坎组成,不同断坎间垂直位移分布呈现此消彼长的特征,不论是整个北翼逆断层西段还是单条断坎,其垂直位移均呈东高西低的不对称分布,位移梯度东高西低,这可能反映了背斜西段晚第四纪褶皱作用的东强西弱。该断层可能是背斜生长过程中为了调节褶皱逐渐紧闭时不断减小的核部空间形成的浅部、无根的前翼次级剪切逆冲断层,本身不会产生中强地震。该断层晚第四纪平均水平缩短速率为0.8mm/a,仅吸收了该区现今GPS地壳缩短速率的1/5。木什背斜和背斜北翼逆断层的生长均遵从根据全球断层数据获得的断层长度>100m的标度律。木什背斜北翼逆断层西段陡坎的幂律回归标度指数n=1.37(R2=0.88),其断层最大位移(Dmax)与断层长度(L)的比值(k)远小于木什背斜的约4.3%,但比全球地震地表破裂带的k值(10-4~10-5)要大1~2个数量级,这表明木什背斜北翼断裂陡坎可能是数个中强震的派生产物,但尚处于断层发育的早期。 | 肖伟鹏 陈杰 李涛 李文巧 Thompson J | 2011 | 地震地质2011，33，2： | 5 |
| 13 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 3 |
| 14 | Impaired CTLA-4 responses in COPD are associated with systemic inflammation显示文摘 | Dino BA Tan Sonia Fernandez PatriciaPrice Martyn A French Philip J Thompson Yuben P Moodley | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 15 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet . 2009 (9666)2009，，9666： | 3 |
| 16 | Emerging therapeutic options for the management of hepatitis C infection显示文摘Until recently the traditional treatment for hepatitis C infection included pegylated interferon and ribavirin combination therapy.The sustained virological response(SVR)seen with this combination is poor and requires lengthy treatment to achieve.Additionally,significant side effects and numerous contraindications prevented many patients from being successfully treated with this therapy.In 2011,two new protease inhibitors,telaprevir and boceprevir,were approved for use with pegylated interferon and ribavirin in the United States by the United States Food and Drug Administration.These agents have significantly improved SVR rates;however significant problems with toxicity remain including severe skin rash and neutropenia.There are a wide range of compounds in late stage development for the future treatment of hepatitis C that exploit many different mechanisms of viral inhibition.Some of these compounds include additional protease inhibitors,like telaprevir and boceprevir,as well as inhibitors of other nonstructural proteins in the viral genome such as NS5A and NS5B,and compounds that target host proteins within the virus.Some of these agents are being developed for oral administration once daily and various combinations are being assessed for use without the need for pegylated interferon and ribavirin.This paper reviews agents in late phase development that may be commercially available within 1-2 years. | J Richard Thompson | 2014 | World Journal of Gastroenterology2014，20，23： | 2 |
| 17 | Centrifuge modeling of transport processes for pollutants in soils显示文摘 | Arulanandan K Thompson P Y Kutter B L Meegoda N J Muraleetharan K K Yogachandran C | 1988 | Journal of Geotechnical Engineering Division American Society of Civil Engineering1988，，： | 2 |
| 18 | The crystal chemistry underlying ferroelectricity in Bi4 Ti3 O12,Bi3TiNbO9,and Bi2WO6显示文摘 | WITERSRL THOMPSONJGRL THOMPSON J D etal | 1991 | J Solid State Chem1991，94，： | 2 |
| 19 | 澳大利亚MSA体系:通过食用品质评价牛肉品质显示文摘<正>澳大利亚肉类标准(MSA)是一个质量管理体系,旨在为消费者提供牛肉食用品质的准确描述。MSA分级系统中,消费者品尝的感官效果被用来描述牛肉的可口性。简单来讲,未经培训的消费者采用0~100直线标度的方法对牛肉样品的嫩度、多汁性、风味和总体接受度进行测试打分,包括下列语言叙述:不满意等级(无评分级)、普通级(或3星级)、良好级(或4星级)、优级(或5星级)。然后对4个感官指标通过权重换算。 | Pethick D W olkinghorne R P Thompson J M 吴鑫 | 2015 | 中国畜牧杂志2015，51，S1： | 2 |
| 20 | No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer显示文摘AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene. | Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah J Plummer Thomas C Tucker Graham Case Li Li | 2009 | World Journal of Gastroenterology2009，15，30： | 2 |
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