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| 1 | Laparoscopic Partial Nephrectomy With Segmental Renal Artery Clamping:Technique and Clinical Outcomes显示文摘Background:Warm ischemic injury is one of the most important factors affecting renal function in partial nephrectomy(PN).The technique of segmental renal artery clamping emerges as an alternative to conventional renal artery clamping for renal hilar control.Objective:To evaluate the feasibility and efficiency of laparoscopic PN(LPN) with segmental renal artery clamping in comparison with the conventional technique.Design,setting,and participants:A total of 75 patients underwent LPN from June 2007 to November 2009.All patients had T1a or T1b tumor in one kidney and a normal contralateral kidney.Thirty-seven patients underwent surgeries with main renal artery clamping,and 38 underwent surgeries with segmental artery clamping.Intervention:All procedures were performed by the same laparoscopic surgeon.Measurements:Blood loss,operation time,warm ischemia(WI) time,and complications affected renal function before and after operation were recorded.Results and limitations:All LPNs were completed without conversion to open surgery or nephrectomy.The novel technique slightly increased WI time(p < 0.001) and intraoperative blood loss(p = 0.006),while it provided better postoperative affected renal function(p < 0.001) compared with the conventional technique.The total complication rate was 12%.Among the 38 cases where segmental renal artery clamping was performed,7 had to convert to the conventional method.Tumor size and location influenced the number of clamped segmental arteries.Long-term postoperative renal function is still awaited.Conclusions:LPN with segmental artery clamping is safe and feasible in clinical practice.It minimizes the intraoperative WI injury and improves early postoperative affected renal function compared with main renal artery clamping.(C) 2010 European Association of Urology.Published by Elsevier B.V.All rights reserved. | Shao,P.F. Qin,C. Yin,C.J. Meng,X.X. Ju,X.B. Li,J. Lü,Q.A. Zhang,W. Xu,Z.Q.Shao,Pengfei Qin,Chao Yin,Changjun Meng,Xiaoxin Ju,Xiaobing Li,Jie Lü,Qiang Zhang,Wei Xu,Zhengquan] Nanjing Med Univ,Affiliated Hosp 1,Dept Urol,Nanjing,Peoples R China.Guangzhou Rd 300,Nanjing 210029,Peoples R China. | 2011 | 南京医科大学学报(自然科学版)2011，31，7： | 123 |
| 2 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 3 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 4 | Interactions of IL-12A and IL-12B Polymorphisms on the Risk of Cervical Cancer in Chinese Women显示文摘 | Chen, X. J. Han, S. P. Wang, S. N. Zhou, X. Y. Zhang, M. F. Dong, J. Shi, X. Y. Qian, N. F. Wang, X. R. Wei, Q. Y. Shen, H. B. Hu, Z.B. | 2009 | 南京医科大学学报(自然科学版)2009，29，3： | 16 |
| 5 | 中扬子地区碰撞造山形变作用的3个演化阶段显示文摘中法双方在中扬子区联合调查,于前人侧重研究碰撞造山形成作用的基础上, 更加注重探讨碰撞造山的形变作用.以其形变组合顺序依次分为挤压逆冲隆升-走滑 逃逸流变-引张伸展反转3个发育阶段为依据,将该区碰撞造山的过程划分为初造山 期、主造山期和后造山期3个发育时期.对每个阶段的应力应变轴的变化、节理断裂的 转化以及相关构造的演化,就武功山、九岭山和雪峰山的实测资料进行阐述,绘出模式, 并对同构造期形成的岩石测年值作了相应的解释. | 孙岩 舒良树 朱文斌 郭继春 陈祥云 M. Faure J. Charvet Lin Wei | 2001 | 中国科学(D辑)2001，31，6： | 16 |
| 6 | 肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells. | Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone | 2010 | 中华神经外科疾病研究杂志2010，9，1： | 16 |
| 7 | White Matter Abnormalities in Major Depression Biotypes Identified by Diffusion Tensor Imaging显示文摘Identifying data-driven biotypes of major depressive disorder(MDD) has promise for the clarification of diagnostic heterogeneity. However, few studies have focused on white-matter abnormalities for MDD subtyping. This study included 116 patients with MDD and118 demographically-matched healthy controls assessed by diffusion tensor imaging and neurocognitive evaluation.Hierarchical clustering was applied to the major fiber tracts, in conjunction with tract-based spatial statistics, to reveal white-matter alterations associated with MDD.Clinical and neurocognitive differences were compared between identified subgroups and healthy controls. With fractional anisotropy extracted from 20 fiber tracts, cluster analysis revealed 3 subgroups based on the patterns of abnormalities. Patients in each subgroup versus healthy controls showed a stepwise pattern of white-matter alterations as follows: subgroup 1(25.9% of patient sample),widespread white-matter disruption;subgroup 2(43.1% of patient sample), intermediate and more localized abnormalities in aspects of the corpus callosum and left cingulate;and subgroup 3(31.0% of patient sample),possible mild alterations, but no statistically significant tract disruption after controlling for family-wise error. The neurocognitive impairment in each subgroup accompanied the white-matter alterations: subgroup 1, deficits in sustained attention and delayed memory;subgroup 2, dysfunction in delayed memory;and subgroup 3, no significant deficits. Three subtypes of white-matter abnormality exist in individuals with major depression, those having widespread abnormalities suffering more neurocognitive impairments, which may provide evidence for parsing the heterogeneity of the disorder and help optimize typespecific treatment approaches. | Sugai Liang Qiang Wang Xiangzhen Kong Wei Deng Xiao Yang Xiaojing Li Zhong Zhang Jian Zhang Chengcheng Zhang Xin-min Li Xiaohong Ma Junming Shao Andrew J. Greenshaw Tao Li | 2019 | Neuroscience Bulletin2019，35，5： | 9 |
| 8 | Identification of JWA as a novel functional gene responsive to environmental oxidative stress induced by benzo a pyrene and hydrogen peroxide显示文摘 | Chen, R. Qiu, W. Liu, Z. L. Cao, X. J. Zhu, T. Li, A. P. Wei, Q. Y. Zhou, J. W. | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 9 |
| 9 | Efficacy and safety of FIREHAWK abluminal groove filled biodegradable polymer sirolimus-eluting stents for the treatment of long coronary lesions: nine-month angiographic and one-year clinical results from TARGET I trial lona cohort显示文摘 | XU Bo GAO Run-lin ZHANG Rui-yan WANG Hai-chang LI Zhan-quan YANG Yue-jin MA Chang-sheng HAN Ya-ling Alexandra J. Lansky HUO Yong LI Wei Martin B. Leon | 2013 | Chinese Medical Journal2013，，6： | 8 |
| 10 | Possible effect of ENSO on annual sediment discharge of debris flows in the Jiangjia Ravine based on Morlet wavelet transforms显示文摘The multi-time-scale structures of an annual sediment discharge series of debris flow in the Jiangjia Ravine and the Southern Oscillation index are analysed using the method of Morlet wavelet transformations. The possible effects of El Nio episodes on the annual sediment discharge are discussed by comparing the period variations of ENSO and the discharge. The results show that the annual sediment discharge series of debris flow is related to El Nio episodes. Generally, the annual sediment discharge of debris flow is less than usual during an El Nino episode and debris flow is less active. On the contrary, the annual sediment discharge of debris flows is greater than usual during a La Nia episode and debris flows are more frequent. There is a relationship between the annual sediment discharges of debris flow in the Jiangjia Ravine and the summer Southern Oscillation index, with both having quasi-periodic variations of 2 and 5–6 years. | J. H. ZHANG F. Q. WEI S. Z. LIU C. GAO | 2008 | International Journal of Sediment Research2008，23，3： | 5 |
| 11 | NUMERICAL SIMULATION OF TEMPERATURE FIELDS FOR WELD METAL SOLIDIFICATION CRACKING IN STAINLESS STEELS显示文摘This paper has analyzed the influences of the heat input of welding arc, the latent heat of solidifica- tion,fluid flow of liquid metal on the heat conductivity pertaining to welding solidification crack of stainless steels. As a result,two - dimensional heat conduction models with prescribed heat flux mov- ing along the the have been developed that can simulate welding arc, convection and radiation heat loss from top and bottom surfaces of the workpiece. Finally, the finite element model was used to ana- lyze and calculate the temperature field. | R. P. Liu Z. J. Dong and Y. H. Wei( 1)Harbin Research Institute of Welding, Harbin 150080, China 2)National Key Laboratory of Advanced Welding Production Technology, HIT, Harbin 150001, China) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，1： | 5 |
| 12 | Phase 2 trial of linifanib (ABT‐869) in patients with unresectable or metastatic hepatocellular carcinoma显示文摘 | Han Chong Toh Pei‐Jer Chen Brian I. Carr Jennifer J. Knox Sharlene Gill Peter Ansell Evelyn M. McKeegan Barry Dowell Michelle Pedersen Qin Qin Jiang Qian Frank A. Scappaticci Justin L. Ricker Dawn M. Carlson Wei Peng Yong | 2012 | Cancer2012，，2： | 4 |
| 13 | A Light-Independent Allele of Phytochrome B Faithfully Recapitulates Photomorphogenic Transcriptional Networks显示文摘Arabidopsis phytochrome B 的主导的 gain-of-function 等位基因最近被显示授与光无关的、组成的 photomorphogenic (警察) 显型到转基因的植物(苏和 Lagarias, 2007 ) 。在现在的学习,介绍实验的比较抄写被执行估计这些等位基因精确地调整的基因表示的模式是否在野类型的 Arabidopsis 反映 photomorphogenesis 的过程。表示 phyB (YHB ) 的 Y276H 异种的黑暗成年的 phyAphyB 幼苗的整个染色体的抄写侧面揭示了那 YHB 改编以一种光无关的方式的大约 13% Arabidopsis transcriptome。调整 YHB 的 transcriptome 证明品质上类似到但是不到 15 或 50 种的野类型的幼苗的比那些大的份量上 ? 摩尔 ? m ? 2 ? m ? 1 盏连续的红灯(Rc ) 。在 2977 基因之中统计上重要双重(SSTF ) 当光不在时由 YHB 调整了包括光合的仪器, tetrapyrrole/pigment biosynthetic 小径,和早光应答的发信号因素的那些编码部件。Rc 调整的约 80% 基因 SSTF 也是调整 YHB 的。346 调整 YHB 的基因的一个著名子集的表示证明了被 Rc 强烈稀释,显示补偿由 phyC-E 或另外的 Rc 依赖的进程的规定。因为这 346 基因的多数被生理节奏的钟调整,这些结果建议 phyA 独立、 phyB 独立的轻发信号小径强烈影响钟输出。和黑暗成年的 YHB 幼苗的唯一的质体形态学,这些分析显示 YHB 异种经由以一种光无关的方式表明小径的 phyB 的忠诚重建导致组成的 photomorphogenesis。 | Wei Hu Yi-Shin Su J. Clark Lagarias | 2009 | Molecular Plant2009，2，1： | 4 |
| 14 | Atorvastatin Reduces the Ability of Clopidogrel to Inhibit Platelet Aggregation: A New Drug–Drug Interaction显示文摘 | Wei C. Lau Lucy A. Waskell Paul B. Watkins Charlene J. Neer Kevin Horowitz Amy S. Hopp Alan R. Tait David G.M. Carville Kirk E. Guyer Eric R. Bates | 2003 | Circulation: Journal of the American Heart Association2003，，1： | 3 |
| 15 | Increasing surface ozone concentrations in the background atmosphere of Southern China, 1994–2007显示文摘 | Wang T. Wei X. L. Ding A. J. Poon C. N. Lam K. S. Li Y. S. Chan L. Y. Anson M | 2009 | Atmospheric Chemistry and Physics2009，，175： | 3 |
| 16 | SEPARATION OF Ce(Ⅳ) AND Th(Ⅳ) FROM RE(Ⅲ) IN HNO_3 SOLUTION BY CYANEX 923 EXTRACTANT显示文摘1.IntroductionStraightchainalkylphosphineoxidemixtureCyanex923isonecommercialextractantsdevelopedbyCytecCanadaInc..ComparedwithotherphosphinereagelltsuchasTOPO,theextractatlthajsseveraladvantagesincludinglittleliablehydrolyzation,lowsolubilityinaqueo... | J. Lu and D.Q. Li(Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, The Chinese Academy of Sciences, Changchun 130022, China)Z.G. Wei and Z.C. Jiang(Department of Chemistryt Wuhan University, Wuhan 430072, China)Ma | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，2： | 3 |
| 17 | HAZ CRACKING AND HOT DUCTILITY OF Ni_3AI CONTAINING Zr ALLOY显示文摘The HAZ cracking test in EB welding condition and hot ductility test show that the cracking mechanism is the formation of Ni - Ni5Zr eutectic which is resulting from the enrichment of Zr in grain boundaries during welding.In order to eliminate HAZ cracks the diffusion and recrystalization anealing treatment after cast and during cold rolling should be conducted in vacuum or protecting atmosphere and at the same time a slow welding speed is necessary. | B. N. Qian J. L. Li J. T. Guo and B. Z. Wei (1)Institute of Metal Research, The Chinese Academy of Sciences, Shenyang 110015, China 2)Shanghai University, Shanghai 200072, China) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，1： | 3 |
| 18 | Bevacizumab in Combination With Chemotherapy As First-Line Therapy in Advanced Gastric Cancer: A Biomarker Evaluation From the AVAGAST Randomized Phase III Trial显示文摘 | Eric Van Cutsem Sanne de Haas Yoon-Koo Kang Atsushi Ohtsu Niall C. Tebbutt Jian Ming Xu Wei Peng Yong Bernd Langer Paul Delmar Stefan J. Scherer Manish A. Shah | 2012 | Journal of Clinical Oncology2012，，17： | 3 |
| 19 | Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance显示文摘Objective: Lack of effective therapies remains a problem in the treatment of oral squamous cell carcinoma(OSCC), especially in patients with advanced tumors. OSCC development is driven by multiple aberrancies within the cell cycle pathway, including amplification of cyclin D1 and loss of p16. Hence, cell cycle inhibitors of the CDK4/6-cyclin D axis are appealing targets for OSCC treatment. Here, we determined the potency of palbociclib and identified genetic features that are associated with the response of palbociclib in OSCC.Methods: The effect of palbociclib was evaluated in a panel of well-characterized OSCC cell lines by cell proliferation assays and further confirmed by in vivo evaluation in xenograft models. PIK3CA-mutant isogenic cell lines were used to investigate the effect of PIK3CA mutation towards palbociclib response.Results: We demonstrated that 80% of OSCC cell lines are sensitive to palbociclib at sub-micromolar concentrations.Consistently, palbociclib was effective in controlling tumor growth in mice. We identified that palbociclib-resistant cells harbored mutations in PIK3CA. Using isogenic cell lines, we showed that PIK3CA mutant cells are less responsive to palbociclib as compared to wild-type cells with concurrent upregulation of CDK2 and cyclin E1 protein levels. We further demonstrated that the combination of a PI3 K/mTOR inhibitor(PF-04691502) and palbociclib completely controlled tumor growth in mice.Conclusions: This study demonstrated the potency of palbociclib in OSCC models and provides a rationale for the inclusion of PIK3CA testing in the clinical evaluation of CDK4/6 inhibitors and suggests combination approaches for further clinical studies. | Nur Syafinaz Zainal Bernard Kok Bang Lee Zheng Wei Wong Iuan Sheau Chin Pei San Yee Chai Phei Gan Kein Seong Mun Zainal Ariff Abdul Rahman J. Silvio Gutkind Vyomesh Patel Sok Ching Cheong | 2019 | Cancer Biology & Medicine2019，16，2： | 3 |
| 20 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
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