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| 1 | Tamoxifen induced multinucleated cells (symplasts) and distortion of seminiferous tubules in rat testis显示文摘Aim: To evaluate the effect of tamoxifen citrate on male reproductive system of rat. Methods: Groups of male rats were gavaged with tamoxifen at doses of 200 mg.kg·^-1.d^-1, 400 mg·kg·^-1.d^-1 or 800 mg.kg^-1·d^-1 in 0.1 mL olive oil for 10 consecutive days. Controls were treated with 0.1 mL olive oil. Rats were anesthetized and killed on d 3, d 15 or d 35 after the last dose. Testes were collected, processed for paraffin embedding, sectioned at 5μm thickness, stained with H&E and analyzed microscopically. Results: There was a dose-dependent increase in the occurrence of seminiferous tubular distortion with germinal cell sloughing. The highest dose increased the number of multinucleated giant cells on d 3 and d 15. Conclusion: Tamoxifen citrate induces multinucleated giant cells and germinal epithelial sloughing in a dose-dependent manner and these changes are detrimental to male fertility. (Asian J Androl 2003 Sep; 5: 217-220) | Urban J.A.D'Souza | 2003 | Asian Journal of Andrology2003，5，3： | 5 |
| 2 | Deepest exposed crust of Brazil-SHRIMP establishes three events显示文摘 | Hartmann L.A Santos J.O.S Leiete J.A.D McNaughton N.J | | 0，，： | 1 |
| 3 | Effect of heat and enzymatic treatment on the antihypertensive activity of whey protein hydrolysates显示文摘 | Costa E.L Gontijo J.A.D Netto F.M | | 0，，06： | 1 |
| 4 | Effect of tamoxifen on spermatogenesis and tubular morphology in rats显示文摘Aim: To observe the effect of tamoxifen citrate on spermatogenesis and tubular morphology in rats.Methods: The effect of tamoxifen citrate i.g. at doses of 400 and 800 mg·kg^-1·day^-1 in 0.1 mL olive oil for 30 days on seminiferous tubular morphology, seminiferous epithelial diameter (STD), epithelial height (SEH), epididymal sperm count and percent abnormal sperm were evaluated at day 1, 12 and 36 after treatment. Controls were given the vehicle. Results: The higher dose resulted in tubular atrophy on day 31. The STD, SEH and sperm count were decreased and the abnormal spermatozoa increased in a dose-dependent manner with the maximal effect on day 36.Conclusion: Tamoxifen citrate induces tubular shrinkage and atrophy and sperm abnormality at a dose-dependent manner. (Asian J Androl 2004 Sep; 6: 223-226) | Urban J.A.D'Souza | 2004 | Asian Journal of Andrology2004，6，3： | 1 |
| 5 | Computation of phase equilibria by linear programming:a tool for geodynamic modeling and its application to subduction zone decarbonation显示文摘 | Connolly J.A.D | | 0，，： | 1 |
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