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| 1 | Skin bioprinting:the future of burn wound reconstruction?显示文摘Burns are a significant cause of trauma,and over the years,the focus of patient care has shifted from just survival to facilitation of improved functional outcomes.Typically,burn treatment,especially in the case of extensive burn injuries,involves surgical excision of injured skin and reconstruction of the burn injury with the aid of skin substitutes.Conventional skin substitutes do not contain all skin cell types and do not facilitate recapitulation of native skin physiology.Three-dimensional(3D)bioprinting for reconstruction of burn injuries involves layer-by-layer deposition of cells along with scaffolding materials over the injured areas.Skin bioprinting can be done either in situ or in vitro.Both these approaches are similar except for the site of printing and tissue maturation.There are technological and regulatory challenges that need to be overcome for clinical translation of bioprinted skin for burn reconstruction.However,the use of bioprinting for skin reconstruction following burns is promising;bioprinting will enable accurate placement of cell types and precise and reproducible fabrication of constructs to replace the injured or damaged sites.Overall,3D bioprinting is a very transformative technology,and its use for wound reconstruction will lead to a paradigm shift in patient outcomes.In this review,we aim to introduce bioprinting,the different stages involved,in vitro and in vivo skin bioprinting,and the various clinical and regulatory challenges in adoption of this technology. | Mathew Varkey Dafydd O.Visscher Paul P.Mvan Zuijlen Anthony Atala James J.Yoo | 2019 | Burns & Trauma2019，7，1： | 8 |
| 2 | 3.0T三维各向同性肩关节MR关节成像与二维MR关节成像在诊断关节唇病变方面的比较显示文摘目的 使用3.0T成像设备比较三维各向同性MR关节成像与二维MR关节成像对肩关节唇病变的诊断准确性。方法 机构审查委员会批准本回顾性研究,免除了知情同意书。2006年3月—2007年1月,100例病人经3.0T成像设备进行三维各向同性和二维肩关节成像,随后接受关节镜手术。 | J.Y.Jung Y.C.Yoon S.H.Choi J.W.Kwon J.Yoo B.K.Choe 高欣 | 2009 | 国际医学放射学杂志2009，32，2： | 6 |
| 3 | Clinicopathological features of CpG island methylator phenotype‐positive colorectal cancer and its adverse prognosis in relation to KRAS/BRAF mutation显示文摘 | SunLee Nam‐YunCho MinheeChoi Eun J.Yoo Jung‐HoKim Gyeong H.Kang | 2008 | Pathology International2008，，2： | 2 |
| 4 | Electrochemical determination of the degree of atomic surface roughness in Pt-Ni alloy nanocatalysts for oxygen reduction reaction显示文摘Pt-Ni alloy nanocrystals with Pt-enriched shells were prepared by selective etching of surface Ni using sulfuric acid and hydroquinone.The changes in the electronic and geometric structure of the alloy nanoparticles at the surface were elucidated from the electrochemical surface area,the potential of zero total charge(PZTC),and relative surface roughness,which were determined from CO-and CO_(2)-displacement experiments before and after 3000 potential cycles under oxygen reduction reaction conditions.While the highest activity and durability were achieved in hydroquinone-treated Pt–Ni,sulfuric acidtreated one showed the lower activity and durability despite its higher surface Pt concentration and alloying level.Both PZTC and QCO_(2)/QCO ratio(desorption charge of reductively adsorbed CO_(2) normalized by COad-stripping charge)depend on surface roughness.In particular,QCO_(2)/QCO ratio change better reflects the roughness on an atomic scale,and PZTC is also affected by the electronic modification of Pt atoms in surface layers.In this study,a comparative study is presented to find a relationship between surface structure and electrochemical properties,which reveals that surface roughness plays a critical role to improve the electrochemical performance of Pt-Ni alloy catalysts with Pt-rich surfaces. | Tae-Yeol Jeon Seung-Ho Yu Sung J.Yoo Hee-Young Park Sang-Kyung Kim | 2021 | Carbon Energy2021，3，2： | 2 |
| 5 | Tissue Engineering of Functional Salivary Gland Tissue显示文摘 | AkiraJoraku Christopher A.Sullivan James J.Yoo AnthonyAtala | 2009 | The Laryngoscope2009，，2： | 1 |
| 6 | Fetal sonographic diagnosis of aortic arch anomalies显示文摘 | S.‐J.Yoo J.‐Y.Min Y.‐H.Lee K.Roman E.Jaeggi J.Smallhorn | 2003 | Ultrasound Obstet Gynecol2003，，5： | 1 |
| 7 | Fetal sonographic diagnosis of aortic arch anomalies显示文摘 | S.‐J.Yoo J.‐Y.Min Y.‐H.Lee K.Roman E.Jaeggi J.Smallhorn | 2003 | Ultrasound Obstet Gynecol2003，，5： | 1 |
| 8 | Three‐vessel view of the fetal upper mediastinum: an easy means of detecting abnormalities of the ventricular outflow tracts and great arteries during obstetric screening显示文摘 | S. ‐J.Yoo Y.‐H.Lee E. S.Kim H. M.Ryu M. Y.Kim H.‐K.Choi K. S.Cho A.Kim | 2002 | Ultrasound Obstet Gynecol2002，，3： | 1 |
| 9 | Normal pericardial fluid in the fetus: color and spectral Doppler analysis显示文摘 | S.‐J.Yoo J.‐Y.Min Y.‐H.Lee | 2002 | Ultrasound Obstet Gynecol2002，，3： | 1 |
| 10 | Association Between Visceral Obesity and Sarcopenia and Vitamin D Deficiency in Older Koreans: The Ansan Geriatric Study显示文摘 | HyunjooCho Hye J.Yoo Kyung M.Choi Dong S.Choi ChangsuHan | 2012 | J Am Geriatr Soc2012，，4： | 1 |
| 11 | Leading Approaches to Vascularize Kidney Constructs in Tissue Engineering显示文摘There is an unprecedented need for new treatments for renal failure,as the incidence of this disease is increasing disproportionately to advancements in therapies.Current treatments are limited by the availability of viable organs,for which there is a worldwide lack.These treatment modalities also require a substantial amount of infrastructure,significantly limiting the access to care in most countries.Kidney tissue engineering approaches promise to develop alternative solutions that address many of the inadequacies in current care.Although many advancements have been made—primarily in the past decade—in biofabrication and whole-organ tissue engineering,many challenges remain.One major hindrance to the progress of current tissue engineering approaches is establishing successful vascularization of developed engineered tissue constructs.This review focuses on the recent advancements that address the vascular challenge,including the biofabrication of vasculature,whole-organ engineering through decellularization and recellularization approaches,microscale organogenesis,and vascularization using organoids in the context of kidney tissue engineering.We also highlight the specific challenges that remain in developing successful strategies capable of clinical translation. | Diana S.Lim John D.Jackson Anthony Atala James J.Yoo | 2022 | Engineering2022，，12： | 0 |
| 12 | Re nanoclusters anchored on nanosheet supports: Formation of Re-O-matrix bonding and evaluation as all-pH-range hydrogen evolution reaction (HER) electrocatalysts显示文摘Although the water splitting-based generation of hydrogen as an energy carrier can help to mitigate the global problems of energy shortage and climate change,the practical implementation of this strategy is hindered by the absence of inexpensive high-performance electrocatalysts for the hydrogen evolution reaction (HER).Re-based HER electrocatalysts exhibit predictable high performance within the entire pH range but suffer from arduous formation (i.e.,vulnerability to oxidation) and uncontrollable aggregation,which strongly discourages the maximisation of active site exposure required for activity enhancement.To overcome these limitations,we herein hydrothermally synthesise Re nanoclusters uniformly distributed on nanosheet supports,such as reduced graphene oxide nanosheets (Re NCs@rGO),revealing that this hybrid features abundant exposed active sites and high oxidation resistance.The obtained electrocatalysts were elaborately characterized by microscopic and spectroscopic analyses.Also,density functional theory calculations confirm the optimised synthesis of Re NCs@rGO and indicate the crucial role of Re–O–C junction formation in securing durability.The effective suppression of Re nanocluster detachment/dissolution under HER conditions endows Re NCs@rGO with high electron conductivity and electrochemical stability,resulting in a durability superior to that of commercial Pt/C and an activity similar to that of this reference.As a result,Re NCs@rGO exhibited remarkably small HER overpotentials of 110,130,and 93 m V to deliver a current density of 10 mA cm^(-2) in 0.5 M H_(2)SO_(4),1 M PBS,and 1 M KOH,respectively.Thus,Re NCs@rGO is a promising alternative to conventional Pt-group-metal catalysts and should find applications in next-generation high-performance water splitting systems. | Shiyu Xu Hao Li Jeongbok Lee N.Clament Sagaya Selvam Baotao Kang Jin Yong Lee Pil J.Yoo | 2022 | Journal of Energy Chemistry2022，31，6： | 0 |
| 13 | Adenosine-treated bioprinted muscle constructs prolong cell survival and improve tissue formation显示文摘It is crucial to maintaining the viability of biofabricated human-sized tissues to ensure their successful survival and function after transplantation.Adenosine is a purine nucleoside that has the function to suppress cellular metabolism and has been previously proposed as a method to prolong cell viability under hypoxia.In this study,we optimized the dose concentration of adenosine for incorporation into bioprinted constructs to preserve long-term cell viability in vitro.Our results showed that muscle cells(C2C12)containing 6,7,or 8 mM adenosine maintained high cell viability for 20 days under hypoxic conditions(0.1%O2),whereas cells without adenosine treatment showed 100%cell death after 11 days.After 20 days under hypoxic conditions,muscle cells treated with adenosine proliferated and differentiated when transferred to normoxic conditions.From these adenosine concentrations,6 mM was picked as the optimized adenosine concentration for further investigations due to its most effective results on improving cell viability.The bioprinted muscle constructs containing adenosine(6 mM)maintained high cell viability for 11 days under hypoxic conditions,while the control constructs without adenosine had no live cells.For in vivo validation,the bioprinted constructs with adenosine implanted under the dorsal subcutaneous space in mice,showed the enhanced formation of muscle tissue with minimal central necrosis and apoptosis,when compared to the constructs without adenosine.These positive in vitro and in vivo results demonstrate that the use of adenosine is an effective approach to preventing the challenge of hypoxia-induced necrosis in bioprinted tissues for clinical translation. | Dongxu Ke Adam M.Jorgensen Sang J.Lee James J.Yoo Sean V.Murphy | 2021 | Bio-Design and Manufacturing2021，4，3： | 0 |
| 14 | Bioreactor design and validation for manufacturing strategies in tissue engineering显示文摘The fields of regenerative medicine and tissue engineering offer new therapeutic options to restore,maintain or improve tissue function following disease or injury.To maximize the biological function of a tissue-engineered clinical product,specific conditions must be maintained within a bioreactor to allow the maturation of the product in preparation for implantation.Specifically,the bioreactor should be designed to mimic the mechanical,electrochemical and biochemical environment that the product will be exposed to in vivo.Real-time monitoring of the functional capacity of tissue-engineered products during manufacturing is a critical component of the quality management process.The present review provides a brief overview of bioreactor engineering considerations.In addition,strategies for bioreactor automation,in-line product monitoring and quality assurance are discussed. | Diana Lim Eric S.Renteria Drake S.Sime Young Min Ju Ji Hyun Kim Tracy Criswell Thomas D.Shupe Anthony Atala Frank C.Marini Metin N.Gurcan Shay Soker Joshua Hunsberger James J.Yoo | 2022 | Bio-Design and Manufacturing2022，5，1： | 0 |
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