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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | A highly specific and sentitive sandwich blocking ELISA based on baculovirus expressed pseudorabies virus glycoprotein B 显示文摘 | Gut-Winiarska M Jacobs L Kerstens H | 2000 | J Virol Methed2000，88，1： | 1 |
| 3 | Leukotriene receptor antag-onism and the prevention of extracellular matrix degradation duringatherosclerosis and in-stent stenosis显示文摘 | Hlawaty H Jacob MP Louedec L | 2009 | Arterioscler Thromb VascBiol2009，29，4： | 1 |
| 4 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 5 | Review-thermal and non-thermal interaction of microwave radiation with materials显示文摘 | Jacob J Chia L H L Boey F Y C | 1994 | Journal of Materials Science1994，30，21： | 1 |
| 6 | Dietary fat and incidence of type 2 diabetes in older women显示文摘 | Meyer K A Jacobs D R Kushi L H | 2011 | Diabetes Care2011，24，2： | 1 |
| 7 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 8 | Thermal and nonthermal interaction of microwave with materials显示文摘 | JACOB J CHIA L H L BOEY F Y C | 1995 | Journal of Materials Science1995，30，21： | 1 |
| 9 | Pseudorabies virus US3 protein kinase mediates actin stress fiber breakdown显示文摘 | Minnebruggen G Favoreel H W Jacobs L | | 0，，16： | 1 |
| 10 | Randomised phase II study of cisplatin and 5-fluorouracil (5-FU) versus cisplatin alone in advanced squamous cell oesophageal cancer显示文摘 | H Bleiberg T Conroy B Paillot A.J Lacave G Blijham J.H Jacob L Bedenne M Namer P De Besi F Gay L Collette T Sahmoud | 1997 | European Journal of Cancer1997，，8： | 1 |
| 11 | Low-temperature water-gas shift : In-situ DRIFTS-reaction study of a Pt/CeO2 catalyst for fuel cell reformer applications 显示文摘 | JACOBS G WILLIAMS L GRAHAM U THOMAS G A SPARKS D E DAVIS B H | 2003 | J Phys Chem B2003，107，10： | 1 |
| 12 | Radiation curing of poly-methyl-methacrylate using a variable power microwave source 显示文摘 | CHIA L H L JACOB J BOEY F Y C | 1995 | Journal of Materials Processing Technology1995，48，14： | 1 |
| 13 | The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced,double-stranded RNA-dependent protein kinase显示文摘 | CHANG H W WASTON J C JACOBS B L | 1992 | PNAS1992，89，11： | 1 |
| 14 | Perturbation of B and T cell development predisposition to lymphomagenesis in Eμ-myc transgenic mice required the Bmi-1 显示文摘 | Alkema M J Jacobs H Van L M | 1997 | Oncogene1997，15，8： | 1 |
| 15 | The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms显示文摘 | DAVIES M V CHANG H W JACOBS B L | 1993 | J Virol1993，67，3： | 1 |
| 16 | Rest-activity patterns of premature infants are regulated by cycled lighting 显示文摘 | Rivkees SA Mayes L Jacobs H | 2004 | Pediattics2004，113，4： | 1 |
| 17 | Skin irritants and contact sensitizers induce Langerhans cell migration and maturation at irritant concentration显示文摘 | Jacobs J J Lehe C L Hasegawa H | 2006 | Exp Dermatol2006，15，6： | 1 |
| 18 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 19 | Scaling up inductive logic programming bv learning from interpretations显示文摘 | H Blockeel L De Raedt N Jacobs | 1999 | Data Mining and Knowledge Discovery1999，3，1： | 1 |
| 20 | The microstructure and properties of IN718 rings produced by centrifugal spray deposition 显示文摘 | Barratt M D Dowson A L Jacobs M H | 2004 | Materials Science and Engineering A2004，383，12： | 1 |
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