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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Identifi- cation and subtyping of Francisella by pyrosequencing and signature matching of 16S rDNA fragments 显示文摘 | Jacob D Wahab T Edvinsson B Peterzon A Boskani T Farhadi L Barduhn A Grunow R Sandstrom G | 2011 | Lett Appl Microbiol2011，53，6： | 1 |
| 3 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 4 | Phylogeneticsof Panicoideae (Poaceae) based on chloroplast and nuclear DNAsequences 显示文摘 | Teerawatananon A Jacobs S W L Hodkinson T R | 2011 | Telopea2011，13，11： | 1 |
| 5 | Thermal expansion anomalies and spontaneous magnetostriction in R2 Felt C intermetallic compounds 显示文摘 | Andreev A V De Boer F R Jacobs T H | 1991 | Physica B1991，175，： | 1 |
| 6 | The systemic inflammatory response syndrome ( SIRS ) : immunology and potential immunotherapy显示文摘 | Darville T Giroir B Jacobs R | 1993 | Infection1993，21，5： | 1 |
| 7 | The systemic inflammatory response syndrome (SIRS):immunology and potential immunotherapy显示文摘 | Darville T Giroir B Jacobs R | 1993 | Infection1993，21，： | 1 |
| 8 | MALDITOF MS of phosphorylated lipids in biological fluids using immobilized metal affinity chromatography and a solid ionic crystal matrix显示文摘 | HAM B M JACOB J T COLE R B | 2005 | Analytical Chemistry2005，77，14： | 1 |
| 9 | Type IV secretion system is not involved in infection process in citrus 显示文摘 | Jacob T R Laia M L Moreira L M | 2014 | International Journal of Microbiology2014，，： | 1 |
| 10 | The systemic inflammatory response syndrome(SIRS): immunology and potential immunotherapy显示文摘 | Darville T Giroir B Jacobs R | 1993 | Infection1993，21，5： | 1 |
| 11 | Mineral composition of pigeon milk显示文摘 | B Shenoy K Jacob R T | 1990 | Experientia1990，46，： | 1 |
| 12 | Plasma surface modification of biomedical polymers:influence on cell-material interaction显示文摘 | Jacobs T Morent R Geyter ND | | 0，，05： | 1 |
| 13 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 14 | Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1A, 2B,and 2X on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci显示文摘 | Nagai K Davies T A Jacobs M R | 2002 | Antimicrob Agents Chemother2002，46，5： | 1 |
| 15 | Carbohydrates, dietary fiber, and incident type 2 diabetes in older women 显示文摘 | Meyer K A Kushi L H Jacobs D R J Slavin J Sellers T A Folsom A R | 2000 | The American Journal of Clinical Nutrition2000，71，4： | 1 |
| 16 | Estimating Geoid Height Change in North America: Past, Present and Future显示文摘 | JACOB T WAHR J GROSS R | 2012 | Journal of Geodesy2012，86，5： | 1 |
| 17 | Selective angiotensin Ⅱ receptor receptor antagonism reduces in - sulin resistance in obese Zucker rats显示文摘 | Henriksen E J Jacob S Kinnick T R | 2001 | Hyperten - sion2001，，38： | 1 |
| 18 | Iterative fuzzy image segmentation显示文摘 | Huntsberger T L Jacobs C L Cannos R L | 1985 | Pattern Recognition1985，18，2： | 1 |
| 19 | Percutaneous imaging-guided core breast biopsy: 5 years experience in a corn munityhospital显示文摘 | Margolin F R Leung J W T Jacobs R P | 2001 | AJR Am J Roentgenol2001，177，3： | 1 |
| 20 | The Centerline Pressure and Cavity Shape of Horizontal Plane Choked Vapor Jets with Low Condensation Potential显示文摘 | Eden T J Miller T F Jacobs H R | 1998 | Journal of Heat Transfer Transactions of the ASME1998，120，4： | 1 |
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