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| 1 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 3 | Methods of analysis and separation of chiral flavonoids显示文摘 | JAIME A Y ANDREWS P K DAVIES N M | 2007 | Journal of Chromatography B2007，848，： | 1 |
| 4 | Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the 'AEIOU' features 显示文摘 | Heath M Jaimes N Lemos B | 2008 | J Am Acad Dermatol2008，58，3： | 1 |
| 5 | Exploringthe driving forces behind deforestation in the state ofMexico (Mexico) using geographically weighted regres-sion显示文摘 | Jaimes N B P Sendra J B Delgado M G | 2010 | Applied Geography2010，30，： | 1 |
| 6 | Hydrogen production from sewage sludge using mixed microflora inoculum: Effect of pH and enzymatic pretreatment显示文摘 | JAIME M N RICHARD D ALAN G | 2008 | Bioresource Technology2008，99，14： | 1 |
| 7 | Spanish-Latin American Multicenter Study of Attitudes Toward Organ Donation Among Personnel From Hospital Healthcare Centers显示文摘 | Antonio Ríos Ana López-Navas Marco Antonio Ayala-García María José Sebastián Anselmo Abdo-Cuza Jeannina Alán Laura Martínez-Alarcón Ector Jaime Ramírez Gerardo Mu?oz Juliette Suárez-López Roberto Castellanos Ricardo Ramírez Beatriz González Miguel Angel M | 2013 | Cirugía Espa?ola (English Edition)2013，，： | 1 |
| 8 | Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients:the 'AEIOU ' features 显示文摘 | Heath M Jaimes N Lemos B | 2008 | J Am Acad Dermatol2008，58，3： | 1 |
| 9 | Dermoscopy for the pediatric dermatologist, Part II: dermoscopy of genetic syndromes with cutaneous manifestations and pediatric vascular lesions显示文摘 | Haliasos EC Kerner M Jaimes N | 2013 | Pediatr Dermatol2013，30，2： | 1 |
| 10 | Effect of the packaging method and the storage time on lipid oxidation and colour stability on dry fermented sausage salchichón manufactured with raw material with a high level of mono and polyunsaturated fatty acids显示文摘 | Bego?a Rubio Beatriz Martínez M a Dolores García-Cachán Jordi Rovira Isabel Jaime | 2008 | Meat Science2008，，4： | 1 |
| 11 | Clinical characteristics of Mer- kel cell carcinoma at diagnosis in 195 patients:the ' AEIOU' t~a- tures 显示文摘 | Heath M Jaimes N Lemos B | 2008 | J Am Acad Dermato12008，58，3： | 1 |
| 12 | Hydrogen production from sewage sludge using mixed microflora inocu- lure:effect of pH and enzymatic pretreatment 显示文摘 | Jaime M N Richard D Alan G | 2008 | Bioresource Techno12008，99，： | 1 |
| 13 | Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients:the AEIOU features显示文摘 | Heath M Jaimes N Lemos B | 2008 | J Am Acad Dermatol2008，58，3： | 1 |
| 14 | Taking the stress out of evaluating stress injuries in children显示文摘 | Jaimes C Jimenez M Shabshin N | | 0，，： | 1 |
| 15 | Clinical characteristics of Merkel cell carcinoma at diagnosis in195patients:the“AEIOU”features显示文摘 | Heath M Jaimes N Lemos B | 2008 | J Am Acad Dermatol2008，58，3： | 1 |
| 16 | Evaluation of the genotype, environment and their interaction on carotenoid and ascorbic acid accumulation in tomato germplasm显示文摘 | SALVADOR R ANA M A JAIME C C FERNANDO N | 2011 | Science Food A- gricuhure2011，91，： | 1 |
| 17 | Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients:the'AEIOU'features显示文摘 | Heath M Jaimes N Lemos B | 2008 | J Am Acad Dermato12008，58，3： | 1 |
| 18 | Spitz nevi: a bridge be- tween dermoscopic morphology and histopathology 显示文摘 | Kerner M Jaimes N Scope A | 2013 | Dermatol Clin2013，31，2： | 1 |
| 19 | Clinical characteristics of Merkelcel carcinoma at diagnosis in 195 patients:the“AEIOU”features显示文摘 | Heath M Jaimes N Lemos B | 2008 | J Am Acad Dermatol2008，58，3： | 1 |
| 20 | Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the 'AEIOU' features 显示文摘 | Heath M Jaimes N Lemos B | 2008 | J Am Acad Dermatol2008，58，3： | 1 |
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