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| 1 | Cytotoxicity evaluation and hepatoprotective potential of bioassay guided fractions from Feronia limmonia Linn leaf显示文摘Objective:To evaluate the cytotoxicity and hepatoprotective potentials of extracts,fractions or isolated compound from the leaves of Feronia limonia(F.limonia).Methods:Qualitative phytochemical analysis of extracts,fractions or compound was performed by means of thin layer chromatography and spectroscopic assays.The%purity of compound was measured by analytical HPLC.Extracts,fractions or compound have been individually evaluated for their cytotoxicity effects(10,20,100,250,500,750 and 1 000 μg/mL).Based on the inhibitory concentration(IC_(50)) obtained from the cell viability assay,graded concentrations of extracts,fractions or isolated compound were assessed(10,20,50,100,200 μg/mL) for its hepatoprotective potential against CCl_4-induced hepatotoxicity by monitoring activity levels of serum glutamatic pyruvatic transaminase(SGPT) and serum glutamic oxaloacetic transaminase(SGOT).Results:Results indicated that the methanol extract of F.limonia was non-toxic and hepatoprotective in nature as compared with the petroleum ether extract.The acetone fraction of methanolic extract also showed similar properties but the subsequent two fractions were cytotoxic.However,the pure compound isolated from the penultimate fraction of methanolic extract was non-toxic and hepatoprotective in nature.Biochemical investigations(SCOT,SCPT) further corroborated these cytological observations.Conclusions:It can be concluded from this study that F.limonia methanol extract,some fractions and pure isolated compound herein exhibit hepatoprotective activity.However,cytotoxicity recorded in the penultimate fraction and investigation of structural details of pure compound warrants further study. | Mahendra Jain Rakhee Kapadia Ravirajsinh N Jadeja Menaka C Thounaojam Ranjitsinh V Devkar SH Mishra | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 11 |
| 2 | Esophageal tuberculosis presenting with hematemesis显示文摘Esophageal tuberculosis is rare, constituting about 0.3% of gastrointestinal tuberculosis. It presents commonly with dysphagia, cough, chest pain in addition to fever and weight loss. Complications may include hemorrhage from the lesion, development of arterioesophageal fistula, esophagocutaneous fistula or tracheoesophageal fistula. There are very few reports of esophageal tuberculosis presenting with hematemesis due to ulceration. We report a patient with hematemesis that was due to the erosion of tuberculous subcarinal lymph nodes into the esophagus. A 15-year-old boy presented with hemetemesis as his only complaint. Esophagogastroduodenoscopy(EGD) revealed an eccentric ulcerative lesion involving 50% of circumference of the esophagus. Biopsy showed caseating epitheloid granulomas with lymphocytic infiltrates suggestive of tuberculosis. Computerised tomography of the thorax revealed thickening of the mid-esophagus with enlarged mediastinal lymph nodes in the subcarinal region compressing the esophagus along with moderate right sided pleural effusion. Patient was treated with anti-tuberculosis therapy(Rifampicin, Isoniazid, Pyrazinamide, Ethambutol) for 6 mo. Repeat EGD showed scarring and mucosal tags with complete resolution of the esophageal ulcer. | Samit S Jain Piyush O Somani Rajeshkumar C Mahey Dharmesh K Shah Qais Q Contractor Pravin M Rathi | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 6 |
| 3 | Production model based digital video segmentation显示文摘 | HAMPAPUR A JAIN R C WEYMOUTH T | 1995 | international Journal of Multimedia Tools and Applications1995，1，1： | 1 |
| 4 | Hypersonic pressure,skin-friction and heat transfer distributions on space vehicles:three-dimensional bodies显示文摘 | Jain A C Hayes J R | 2004 | AIAA Journal2004，42，10： | 1 |
| 5 | Segmentation through variable-order surface fitting显示文摘 | Besl P J Jain R C | 1988 | IEEE Transactions on Pattern Analysis and Machine Intelligence1988，10，2： | 1 |
| 6 | Osteopontin promotes vas cular endothelial growth factor-dependent breast tumor growth and angiogenesis 'va autocrine and paraerine mechanisms 显示文摘 | Chakraborty G Jain S Kundu G C | 2008 | Cancer Res2008，68，： | 1 |
| 7 | Efficacy of various collection methods for oocyte retrieval in buffalo 显示文摘 | DAS G K JAIN G C SOLANKI V S | 1996 | Theriogenology1996，46，8： | 1 |
| 8 | an XPS study of the effect of ZDDP on the AW/EP characteristics of molybdenum based additives 显示文摘 | Unnikrishnan R Jain M C Additive-additive interaction: Harinarayan A K | 2002 | Wear2002，252，3： | 1 |
| 9 | Why the bass model fits without decision variables显示文摘 | Bass F M Kvishnan T V Jain D C | 1994 | Marketing Science1994，13，3： | 1 |
| 10 | Using dynamic programming for solving variational problems in version显示文摘 | AMINI A A WEYMOUTH T E JAIN R C | 1990 | Pattern Analysis and Machine Intelligence1990，12，9： | 1 |
| 11 | Formation of an active elective barrier at Al/semiconductor interface : a novel approach in corrosion prevention 显示文摘 | Jain F C Rosato J J Mani G | 1986 | Corrosion1986，42，： | 1 |
| 12 | Methane and nitrous oxide emissions from an irrigated rice of North India显示文摘 | Ghosh Sabyasachi Majumdar Deepanjan Jain M C | 2003 | Chemosphere2003，51，： | 1 |
| 13 | Registration and integration of multiple object views for 3D model construction显示文摘 | Dorai C Wang G Jain K | 1998 | IEEE transaction on pattern analysis and machine intelligence1998，20，1： | 1 |
| 14 | Statistical Pattern Recognition: A Review显示文摘 | Jain A K Duin R P W Mao J C | 2000 | IEEE Transactions on Pattern Analysis and Machine Intelligence2000，22，1： | 1 |
| 15 | Influence of recessshape on the performance of a capillary compen- sated circular thrust pad hydrostatic bearing 显示文摘 | SHARMA S C JAIN S C BHARUKA D K | 2002 | Tribol- ogy International2002，35，6： | 1 |
| 16 | Modeling the Effect of Twinning and Detwinning During Strain-Path Changes of Magnesium Alloy AZ31 显示文摘 | PROUST G TOME C N JAIN A | 2009 | International Journal of Plasticity2009，25，5： | 1 |
| 17 | GLIPR1 tumor suppressor gene expressed by adenoviral vector as neoadjuvant intraprostatic injection for localized intermediate or high-risk prostate cancer preceding radical prostatectomy显示文摘 | SONPAVDE G THOMPSON T C JAIN R K | | 0，，22： | 1 |
| 18 | Central neurocytoma:a multi-disciplinary review显示文摘 | Choudhari KA Kaliaperumal C Jain A | 2009 | Br J Neurosurg2009，23，6： | 1 |
| 19 | Metabolic engineering of an alternative pathway for ascorbic acid biosynthesis in plants显示文摘 | Jain A K Nessler C L | 2000 | Molecular Breeding2000，6，： | 1 |
| 20 | Segmentation through variable order surface fitting显示文摘 | BESL P J JAIN R C | 1988 | IEEE Transactions on Pattern Analysis and Machine Intelligence1988，10，2： | 1 |
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