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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Preemptive mechanical ventilation can block progressive acute lung injury显示文摘Mortality from acute respiratory distress syndrome(ARDS) remains unacceptable, approaching 45% in certain high-risk patient populations. Treating fulminant ARDS is currently relegated to supportive care measures only. Thus, the best treatment for ARDS may lie with preventing this syndrome from ever occurring. Clinical studies were examined to determine why ARDS has remained resistant to treatment over the past several decades. In addition, both basic science and clinical studies were examined to determine the impact that early, protective mechanical ventilation may have on preventing the development of ARDS in at-risk patients. Fulminant ARDS is highly resistant to both pharmacologic treatment and methods of mechanical ventilation. However, ARDS is a progressive disease with an early treatment window that can be exploited. In particular, protective mechanical ventilation initiated before the onset of lung injury can prevent the progression to ARDS. Airway pressure release ventilation(APRV) is a novel mechanical ventilation strategy for delivering a protective breath that has been shown to block progressive acute lung injury(ALI) and prevent ALI from progressing to ARDS. ARDS mortality currently remains as high as 45% in some studies. As ARDS is a progressive disease, the key to treatment lies with preventing the disease from ever occurring while it remains subclinical. Early protective mechanical ventilation with APRV appears to offer substantial benefit in this regard and may be the prophylactic treatment of choice for preventing ARDS. | Benjamin Sadowitz Sumeet Jain Michaela Kollisch-Singule Joshua Satalin Penny Andrews Nader Habashi Louis A Gatto Gary Nieman | 2016 | World Journal of Critical Care Medicine2016，5，1： | 9 |
| 3 | SMARCA4缺失型鼻窦癌:10例SWI/SNF驱动的鼻窦恶性肿瘤遗传学谱系的扩展显示文摘低分化鼻窦癌的分子发病机制近年来备受关注。在鼻窦未分化癌的形态学谱系中,几种未分类的癌被重新归类为具有独特遗传学特征的变异体或实体,包括NUT重排性癌和SMARCB1缺失型癌。作者进一步描述了一种罕见的鼻腔未分化癌样肿瘤,其特征是通过免疫组化染色可检测到SWI/SNF构建体SMARCA4(BRG1)的失活。 | Agaimy A Jain D Uddin N 魏建国(摘译) 袁晓露(审校) | 2020 | 临床与实验病理学杂志2020，36，5： | 8 |
| 4 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 5 | Successful outcome following resection of a pancreatic liposarcoma with solitary metastasis显示文摘Liposarcomas are rare soft tissue tumors, commonly affecting the lower limbs and less commonly the retroperitoneum. Although other organs can be affected,the pancreas is one of the rarest, and metastasis at presentation has never been reported. We describe the case of a 76-year-old gentleman presenting with abdominal pain and an abdominal mass. Imaging confirmed a primary tumor in the body and tail of the pancreas, with a metastatic deposit in the mesentery adjacent to the second part of the duodenum. Biopsy confirmed a liposarcoma, and subsequently a complete surgical excision was achieved. He then received adjuvant radiotherapy and has remained disease free for the next 26 mo. | IM Dodo JA Adamthwaite P Jain A Roy PJ Guillou KV Menon | 2005 | World Journal of Gastroenterology2005，11，48： | 5 |
| 6 | Data clustering:a review显示文摘 | JAIN A K MURTY M N FLYNN P J | 1999 | AGM Computing Surveys1999，31，3： | 2 |
| 7 | Elevated serum bone sialoprotein and osteopontin in colon,breast,prostate,and lung cancer显示文摘 | Fedarko NS Jain A Karadag A | | 0，，04： | 2 |
| 8 | Locating text in complex color images显示文摘 | Zhong Y Jain A K | 1998 | Pattern Recognition1998，28，10： | 2 |
| 9 | The role of endoscopy in the evaluation of suspected choledocholithiasis显示文摘 | John T. Maple Tamir Ben-Menachem Michelle A. Anderson Vasundhara Appalaneni Subhas Banerjee Brooks D. Cash Laurel Fisher M. Edwyn Harrison Robert D. Fanelli Norio Fukami Steven O. Ikenberry Rajeev Jain Khalid Khan Mary Lee Krinsky Laura Strohmeyer Jason A | 2010 | Gastrointestinal Endoscopy2010，，1： | 2 |
| 10 | Pituitary abscess: series of six cases显示文摘 | Jain KC arma A ahapatra AK | | Br J Neurosurg0，1，： | 2 |
| 11 | Automatic road identification and labeling in Landsat 4 TM images显示文摘 | Ton J Jain A K Enslin W R | 1989 | Photogrammetric Engineering & Remote Sensing1989，43，： | 2 |
| 12 | In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica显示文摘 | Shukla A Rasik AM Jain GK | 1999 | J Ethnopharmacol1999，65，： | 2 |
| 13 | Methylphenols removal from water by low-cost adsorbents显示文摘 | Bhatnagar A Jain A K | 2002 | J Colloid Interface Sci2002，251，： | 1 |
| 14 | Production model based digital video segmentation显示文摘 | HAMPAPUR A JAIN R C WEYMOUTH T | 1995 | international Journal of Multimedia Tools and Applications1995，1，1： | 1 |
| 15 | Hypersonic pressure,skin-friction and heat transfer distributions on space vehicles:three-dimensional bodies显示文摘 | Jain A C Hayes J R | 2004 | AIAA Journal2004，42，10： | 1 |
| 16 | Fingerprint image enhancement: algorithm and performance evaluation显示文摘 | LIN Hong WANG Yi-fei JAIN A | 1998 | IEEE Trans on Pattern Analysis and Machine intelligence1998，20，8： | 1 |
| 17 | Time and pH Dependent Colon Specific, Pulsatile Delivery of Theophylline for Nocturnal Asthma显示文摘 | Mastiholimath V S Dandagi P M Samata Jain S Gadad A P Kulkarni A R | 2007 | International Journal of Pharmaceutics2007，328，： | 1 |
| 18 | Timing, quantification and tectonic modelling of Pliocene-Quartenary movements in the NW Himalaya:evidence from fission track dating显示文摘 | Kumar D Singh S | 2000 | Earth and Planetary Science Letters2000，179，43： | 1 |
| 19 | Antibody response to crude cell lysate of propionibacterium acnes and induction of pro-inflammatory cytokines in patients with acne and normal healthy subjects显示文摘 | Basal E Jain A Kaushal GP | 2004 | J Microbiol2004，42，2： | 1 |
| 20 | Phenotypic switching and its implications for the pathogenesis of cryptococcus neoformans 显示文摘 | Jain N Guerrero A Fries BC | 2006 | FEMS Yeast Res2006，6，4： | 1 |
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