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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Alkaloids in plants显示文摘 | James W O | 1953 | Endeavor1953，，12： | 1 |
| 3 | An oilseed halophyte for seawater irrigation显示文摘 | Edward P G James W O | 1991 | Science1991，251，： | 1 |
| 4 | Sleep Apnea Following Stroke显示文摘 | Harbison J A James O F W Gibson G J | 2000 | Crebrovase Dis2000，10，2： | 1 |
| 5 | Meehanochemical Synthesis of Homo- and Hetero-rare-earth ( Ill ) Metal-Organic Frameworks by Ball Milling显示文摘 | Yuan W O'Connor J James S L | 2010 | Cryst Eng Comm2010，12，： | 1 |
| 6 | Com- pression of Synthetic Aperture Radar Video Phase History Data Using Trellis-Coded Quantization Techniques 显示文摘 | JAMES W O MICHAEL W M BOBBY R H | 1999 | IEEE Transaction on Geoscience and Remote Sensing1999，37，2： | 1 |
| 7 | Mu-ltifrequency measurements of the effects of soil moisture,soil texture and surface roughness显示文摘 | James R W Pecgy E O Thomas J J | 1983 | IEEE Transactions on Geoscience and Remote Sensing1983，21，1： | 1 |
| 8 | Interactive design of semi-rigid steel frames 显示文摘 | BALAUR S D JAMES W O | 1999 | Journal of Structural Engineering ASCE1999，125，： | 1 |
| 9 | Interactive design of semirigid steel frames 显示文摘 | Balaur S D James W O | 1999 | Journal of Structural Engineering1999，125，5： | 1 |
| 10 | Effect of 3-methyl- cholanthrene on monooxygenase, epoxide hydrolase, and gtutathione S- transferase activities in small estuarine and freshwater fish 显示文摘 | James M O Heard C S Hawkins W E | 1988 | Aquatic Toxicology1988，12，1： | 1 |
| 11 | Sonic anemometer tilt correction algorithms显示文摘 | James M W P O Steven A S Steven | 2001 | Boundary-Layer Meteor2001，99，： | 1 |
| 12 | How Business Schools Lost Their Way显示文摘 | BENNIS W G JAMES O | 2005 | Harvard Business Review2005，83，5： | 1 |
| 13 | Computer simulation of fatigue crack initiation 显示文摘 | MORRIS W L JAMES M R BUCK O | 1980 | Engineering Fracture Mechanics1980，13，1： | 1 |
| 14 | Cued memory reactivation during sleep influences skill learning 显示文摘 | James W Antony Eric W Gobel Justin K O'Hare | 2012 | Nat Neurosci2012，15，8： | 1 |
| 15 | Fatty acid profiling ofChlamydomonas reinhardtii under nitrogen deprivation 显示文摘 | James G O Hocart C H Hillier W | 2011 | Bioresour Technol2011，102，3： | 1 |
| 16 | Spontaneous improvement in late rectal mucosal changes after radiotherapy for prostate cancer显示文摘 | Peter C O’Brien Christopher S Hamilton James W Denham Ralph Gourlay C.Ian V Franklin | 2004 | International Journal of Radiation Oncology, Biology, Physics2004，，1： | 1 |
| 17 | Effect of particle size distribution and aggregation on electroacoustic measurments of ζ potential显示文摘 | James M Hunter R J O'Brien R W | 1992 | Langmuir1992，8，： | 1 |
| 18 | Sudden-enlarge-ment Energy Disspator for Mica Dam显示文摘 | Samuel O Ressell James W Ball | 1967 | Journal of the Hydraulics Division ASCE1967，7，： | 1 |
| 19 | Port Governance in China : A Review of Policies in an Era of Internation-alizing Port Management Practices 显示文摘 | JAMES J W NG A K Y DANIEL O | 2004 | Transport Poli- cy2004，，11： | 1 |
| 20 | Evaluation of projects for rehabilitation of highway bridges显示文摘 | SOBANJO J O STUKHART G JAMES R W | 1994 | Journal of Structural Engineering-ASCE1994，120，5： | 1 |
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