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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | 选择性雄激素受体调节剂治疗迟发性男性性腺功能低下症显示文摘几种睾酮制剂用于治疗老年男性性腺功能减退。这些疗法在其便利性、灵活性、区域供应和费用等方面有区别,但有共同的药代动力学基础,同时缺乏长期安全性数据。简洁和成本较低的基于药代动力学的注册临床试验使得开发改善性的治疗迟发性性腺功能减退的新疗法的商业动机减少了。在前列腺、头发、皮肤受雄激素缺乏影响的患者中,选择性雄激素受体调节剂已被证明可以提供合成代谢的好处。(目前,选择性雄激素受体调节剂的临床进展集中在有限定身体功能的临床终点的急性肌肉萎缩和低体重)。在具有有益的药理、理想的药代动力学的选择性雄激素受体调节剂应用于治疗迟发性男性性腺功能低下症前,其在男性性腺功能低下治疗中关于临床缺陷的更清晰的监管是必须的。 | Christopher C Coss Amanda Jones Michael L Hancock Mitchell S Steiner James T Dalton | 2014 | Asian Journal of Andrology2014，16，2： | 3 |
| 3 | Prognostic value of growth-differentiation factor-15 in patients with non ST elevation acute coronary syndrome 显示文摘 | Wollert K C Kempf T Peter T Olofsson S James S Johnston N | 2007 | Circulation2007，115，： | 1 |
| 4 | ACC/AHA Guidelines for percutaneous coronary intervention 显示文摘 | Smith Jr James T | 2001 | Circulation2001，103，24： | 1 |
| 5 | Effect of enzyme concentration and storage temperature on the formation of slowly digestible starch from cooked debranched rice starch显示文摘 | GURAYA H S JAMES C CHAMPAGNE E T | 2001 | Starch/Starke2001，53，： | 1 |
| 6 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 7 | Reconstructing the early evolution of Fungi using a six-gene phylogeny显示文摘 | James T Y Kauff F Schoch C L | 2006 | Nature2006，443，7113： | 1 |
| 8 | Plate Cooling-technologies and Market Requirements显示文摘 | James F E Michael T C | 2002 | AISE Steel Technology2002，79，6： | 1 |
| 9 | Fabrication of ,solid state dye - sensitized TiO2 solar cells eombined with polypyrrole 显示文摘 | James C Hideo T | 2000 | Journal of Applied Phyeology2000，，12： | 1 |
| 10 | Apractical guide to ass- essment of ventricular diastolic function using Doppler echocar- diography显示文摘 | Gerald I C Joseph F P James D T | 1996 | JACC1996，27，7： | 1 |
| 11 | Pulmonary toxicity of single wall carbon nano-tubos in mice 7 and 90 days after intratracheal instillation显示文摘 | LAM C W JAMES J T MCCLUSKEY R | 2004 | Toxicological Sciences2004，77，1： | 1 |
| 12 | A practical method for calculating largest Lyapunov exponents from small data sets显示文摘 | Michael T R James J C Carlo J D L | 1993 | Physica D1993，65，2： | 1 |
| 13 | Abnormal corneal ep- ithelial wound healing inpartial-thichness removal of lim- bal epithelium 显示文摘 | JAMES J Y C SCHEFFER C G T | 1991 | Invest Ophthalmol Vis Sci1991，32，1： | 1 |
| 14 | Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation显示文摘 | Lam C W James J T McCluskey R | 2004 | Toxicological Sciences2004，77，： | 1 |
| 15 | 显示文摘 | Yi Z James T Christin C | 2000 | Biol Chem2000，275，24： | 1 |
| 16 | Identification of inport residues in metal-chelate recognition by monoclonal antibodies显示文摘 | Delehanty James B Jones R M Bishop T C | 2003 | Biochemistry2003，42，14： | 1 |
| 17 | Antithrombin activity of fucoidan显示文摘 | Frank C James B M Rita E T | 1989 | J Biol Chem1989，264，： | 1 |
| 18 | Aluminum alloys for aircraft structure显示文摘 | WILLIAM C JOHN L JAMES T | 2002 | Advanced Materials Processes2002，160，12： | 1 |
| 19 | Retrieval-induced forgetting in Alzheimer' s disease 显示文摘 | MOUL1N J A C PERFECT T J CONWAY M A JONES R W JAMES N | 2002 | Neuropsy- chologia2002，40，： | 1 |
| 20 | pulmonary toxicity of single-well carbon nanotubes in mice 7 and 90 days after intratracheal instillation显示文摘 | LAM C W JAMES J T MCCLUSKEY R | 2004 | Toxicological Sciences2004，77，1： | 1 |
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