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| 1 | Rotational assisted endoscopic retrograde cholangiopancreatography in patients with reconstructive gastrointestinal surgical anatomy显示文摘AIM: To evaluate the success rates of performing therapy utilizing a rotational assisted enteroscopy device in endoscopic retrograde cholangiopancreatography(ERCP) in surgically altered anatomy patients. METHODS: Between June 1, 2009 and November 8, 2012, we performed 42 ERCPs with the use of rotational enteroscopy for patients with altered anatomy(39 with gastric bypass Roux-en-Y, 2 with Billroth Ⅱ gastrectomy, and 1 with hepaticojejunostomy associated with liver transplant). The indications for ERCP were: choledocholithiasis: 13 of 42(30.9%), biliary obstruction suggested on imaging: 20 of 42(47.6%), suspected sphincter of Oddi dysfunction: 4 of 42(9.5%), abnormal liver enzymes: 1 of 42(2.4%), ascending cholangitis: 2 of 42(4.8%), and bile leak: 2 of 42(4.8%). All procedures were completed with the Olympus SIF-Q180 enteroscope and the Endo-Ease Discovery SB overtube produced by Spirus Medical. RESULTS: Successful visualization of the major ampulla was accomplished in 32 of 42 procedures(76.2%). Cannulation of the bile duct was successful in 26 of 32 procedures reaching the major ampulla(81.3%). Successful therapeutic intervention was completed in 24 of 26 procedures in which the bileduct was cannulated(92.3%). The overall intention to treat success rate was 64.3%. In terms of cannulation success, the intention to treat success rate was 61.5%. Ten out of forty two patients(23.8%) required admission to the hospital after procedure for abdominal pain and nausea, and 3 of those 10 patients(7.1%) had a diagnosis of post-ERCP pancreatitis. The average hospital stay was 3 d.CONCLUSION: It is reasonable to consider an attempt at rotational assisted ERCP prior to a surgical intervention to alleviate biliary complications in patients with altered surgical anatomy. | Majed El Zouhairi James B Watson Svetang V Desai David K Swartz Alejandra Castillo-Roth Mahfuzul Haque Paul S Jowell Malcolm S Branch Rebecca A Burbridge | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，3： | 10 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 4 | Lactobacillus rhamnosus GG decreases TNF- α production in lipopolysaccharide-activated marine macrophages by a contact-independent mechanism显示文摘 | JEREMY A JAMES V | 2003 | Cellular Microbiology2003，5，4： | 1 |
| 5 | Polymorphisms of TLR4 but not CD14 are associated with a decreased risk of aggressive periodontitis显示文摘 | JAMES J A POULTON K V HAWORTH S E | 2007 | J Clin Periodontol2007，34，2： | 1 |
| 6 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 7 | Lactobacillus rhamnosus GG decreasesTNF-aproduction in lipopolysaccharide-activated murinemacrophages by a contact-independent mechanism显示文摘 | Jeremy A James V | 2003 | CellularMicrobiology2003，5，4： | 1 |
| 8 | Maximising graduatestatus in pre-registration nursing programmes : utilising problembased leaming显示文摘 | McGarry J Aubeeluck A James V | 2011 | Nurse Educ Pract2011，11，6： | 1 |
| 9 | Thermoeconomics applied to an air conditioning system with cogeneration 显示文摘 | Tozer R Serrano M A L Capilla A V James R | 1996 | Building Sero Eng Res Tech1996，17，1： | 1 |
| 10 | Recent advance in techniques for hyperspectral image processing显示文摘 | Antonio P Jon A B Joseph W B Jason B Lorenzo B Gustavo C V Jocelyn C Mathieu F Paolo G Anthony G Mattia M James C T Giovanna T | 2009 | Remote Sensing of Environment2009，113，： | 1 |
| 11 | Knockdown of microRNA- 21 inhibits proliferation and increases cell death by targeting programmed cell death 4 (PDCIM) in pancreatic ductal adenocarcinoma 显示文摘 | Bhatti I Lee A James V | 2010 | J Gastrointest Surg2010，15，1： | 1 |
| 12 | Measuring quaternary ammonium cleaning agents with ion selective electrodes 显示文摘 | MICHAEL A P BERNARD J V JAMES M M | 2006 | Analytica Chimica Acta2006，570，2： | 1 |
| 13 | A new classification system for congenital laryngeal cysts显示文摘 | FORTE V FUOCO G JAMES A | 2004 | Laryngoscope2004，114，： | 1 |
| 14 | Improved technique for determining complex permittivity with the transmission/reflection method显示文摘 | James Baker Jarvis Vanzura E V Kissick W A | | 0，，8： | 1 |
| 15 | Detection of DNA methylation changes in micropropagated banana plants using methylation-sensitive amplification polymorphism (MSAP) 显示文摘 | Echeverria S P Valencia V H James K A | 2001 | Plant Sci2001，161，2： | 1 |
| 16 | Fecal lactoferrin is a sensitive and specific marker in identifying intestinal inflammation显示文摘 | Sunanda V Kane William J Sandborn Paul A Rufo Anna Zholudev James Boone David Lyerly Michael Camilleri Stephen B Hanauer | 2003 | The American Journal of Gastroenterology2003，，： | 1 |
| 17 | Hypoxic ischaemic encephalopathy显示文摘 | James A Patel V | 2014 | Paediatr Child Health2014，24，9： | 1 |
| 18 | Knockdown of microRNA- 21 inhibits proliferation and increases cell death by targeting programmed cell death 4 (PDCD4) in pancreatic ductal adenocarcinoma 显示文摘 | Bhatti I Lee A James V | 2011 | J Gastrointest Surg2011，15，1： | 1 |
| 19 | The phanerozoic record of global sea-level change显示文摘 | KENNETH G MILLER MICHELLE A KOMINZ JAMES V BRO-WNING | 2005 | Science2005，，310： | 1 |
| 20 | Transgene behaviour across two generations in a large random population of transgenic rice plants produced by particle bombardment显示文摘 | Vain P James V A Worland B | 2002 | Theoretical and Applied Genetics2002，105，： | 1 |
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