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| 1 | Mediastinal node staging by positron emission tomographycomputed tomography and selective endoscopic ultrasound with fine needle aspiration for patients with upper gastrointestinal cancer:Results from a regional centre显示文摘AIM To investigate the impact of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) and positron emission tomography-computed tomography(PET-CT) in the nodal staging of upper gastrointestinal(GI) cancer in a tertiary referral centre.METHODS We performed a retrospective review of prospectively recorded data held on all patients with a diagnosis of upper GI cancer made between January 2009 and December 2015. Only those patients who had both a PET-CT and EUS with FNA sampling of a mediastinal node distant from the primary tumour were included. Using a positive EUS-FNA result as the gold standard for lymph node involvement, the sensitivity, specificity, positive and negative predictive values(PPV and NPV) and accuracy of PET-CT in the staging of mediastinal lymph nodes were calculated. The impact on therapeutic strategy of adding EUS-FNA to PET-CT was assessed.RESULTS One hundred and twenty one patients were included. Sixty nine patients had a diagnosis of oesophageal adenocarcinoma(Thirty one of whom were junctional), forty eight had oesophageal squamous cell carcinoma and four had gastric adenocarcinoma. The FNA results were inadequate in eleven cases and the PET-CT findings were indeterminate in two cases, therefore thirteen patients(10.7%) were excluded from further analysis. There was concordance between PET-CT and EUS-FNA findings in seventy one of the remaining one hundred and eight patients(65.7%). The sensitivity, specificity, PPV and NPV values of PET-CT were 92.5%, 50%, 52.1% and 91.9% respectively. There was discordance between PET-CT and EUS-FNA findings in thirty seven out of one hundred and eight patients(34.3%). MDT discussion led to a radical treatment pathway in twenty seven of these cases, after the final tumour stage was altered as a direct consequence of the EUS-FNA findings. Of these patients, fourteen(51.9%) experienced clinical remission of a median of nine months(range three to forty two months). CONCLUSION EUS-FNA leads to altered staging of upper GI cancer, resulting in more patients receiving radical treatment that would have been the case using PET-CT staging alone. | Chris Harrington Lyn Smith Jennifer Bisland Elisabet López González Neil Jamieson Stuart Paterson Adrian John Stanley | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，1： | 4 |
| 2 | The effect of antireflux operation on lower oesophageal sphincter tone and postprandial symptoms显示文摘 | Lundell L Myer JC Jamieson G | 1993 | Scand J Gastroenterol1993，28，6： | 1 |
| 3 | Metastatic acinic cell car- cinoma of the parotid gland with ectopic ACTH syndrome显示文摘 | Jamieson L Taylo S M Smith A | 2007 | Oto- laryngol Head Neck Surg2007，136，1： | 1 |
| 4 | Matrix met- alloproteinase-10 is a critical effector of protein kinase Ciota- Par6alpha-mediated lung cancer显示文摘 | Frederick LA Matthews JA Jamieson L | 2008 | Oncogene2008，27，35： | 1 |
| 5 | The effects of Type A behavior dimensions and optimism on coping strategy,health, and performance 显示文摘 | Lee C Ashford S J Jamieson L F | 1993 | Journal of Organizational Behavior1993，，2： | 1 |
| 6 | A quantitative analysis of amino acids in pollen collected by bees显示文摘 | AUCLAIR J L JAMIESON C A | 1948 | Science1948，108，： | 1 |
| 7 | SLC11A1 (NRAMP1) but not SLC11A2 ( NRAMP2 ) polymorphisms are associated with susceptibility to tuberculosis in a hlgh-incidence community in South Africa 显示文摘 | HOAL E G LEWIS L A JAMIESON S E | 2004 | Int J Tuberc Lung Dis2004，8，12： | 1 |
| 8 | What prosthesis should be used at valve re replacement after structural valve deterioration of a bioprosthesis显示文摘 | Lau L Jamieson W R Hughes C | 2006 | Ann Thorac Surg2006，82，6： | 1 |
| 9 | Src and FAK kinases cooperate to phòsphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness 显示文摘 | Brown M C Cary L A Jamieson J S | 2005 | Mol Biol Cell2005，16，9： | 1 |
| 10 | Detection of lipoprotein (a) in intraparenchymal cerebral vessels: correlation with vascular pathology and clinical histry显示文摘 | Jamieson DG Fu L Usher DC | 2001 | Exp Mal Pathol2001，71，2： | 1 |
| 11 | Temperature and time dependence of orthopositronium formation in polystyrene显示文摘 | Peng Z L Olson B G MeGervey J D Jamieson A M | 1998 | Polymer1998，40，： | 1 |
| 12 | Major liver resectionwithout a blood transfusion: is it a realistic objective 显示文摘 | Jamieson GG Corbel L Campion JP | 1992 | Surgery1992，112，1： | 1 |
| 13 | Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer 显示文摘 | Regala RP Weems C Jamieson L | 2005 | Cancer Res2005，65，9： | 1 |
| 14 | Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity显示文摘 | WEEMS C JAMIESON L | 2005 | J Bial Chem2005，280，31： | 1 |
| 15 | Detection of llpoprotcin (a) in intraparenchymal cerebral vessels:correlation with vascular pathology and clinical histry显示文摘 | Jamieson DG Fu L Usher DC | 2001 | Exp Mal Pathol2001，71，2： | 1 |
| 16 | A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells 显示文摘 | Stallings-Mann M Jamieson L Regala R P | 2006 | Cancer Res2006，66，3： | 1 |
| 17 | A test of Ras- mussen' s risk management framework in the food safety domain: BSE in the UK 显示文摘 | Cassano - Piche A L Vieente K J Jamieson G A | 2009 | Theoretical Issues in Ergonomics Science2009，10，4： | 1 |
| 18 | Analyses of expressed sequence tags from apple显示文摘 | NEWCOMB R D CROWHURST R N GLEAVE A P RIKKERINK E H A ALLAN A C BEUNING L L BOWEN J H GERA E JAMIESON K R JANSSEN B J LAING W A MCARTNEY S NAIN B ROSS G S SNOWDEN K C SOULEYRE E J F WALTON E F YAUK Y K | 2006 | Plant Physiology2006，141，： | 1 |
| 19 | The fibrillar hier- archy in liquid crystalline polymers显示文摘 | Sawyer L C Chen R T Jamieson M G | 1993 | J Mater Sci1993，28，： | 1 |
| 20 | SHRP Results on Binder--Aggregate Adhesion and Resistance to Strip- ping显示文摘 | Jamieson I L Mouhhrop J S Jones D R | 1993 | Asphalt Yearbook1993，1，： | 1 |
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