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| 1 | SFRP4 expression correlates with epithelial mesenchymal transitionlinked genes and poor overall survival in colon cancer patients显示文摘BACKGROUND Colon cancer is among the most commonly diagnosed cancers in the United States with an estimated 97220 new cases expected by the end of 2018.It affects 1.2 million people around the world and is responsible for about 0.6 million deaths every year.Despite decline in overall incidence and mortality over the past 30 years,there continues to be an alarming rise in early-onset colon cancer cases(<50 years).Patients are often diagnosed at late stages of the disease and tend to have poor survival.We previously showed that the WNT“gatekeeper”gene,secreted frizzled-related protein 4(SFRP4),is over-expressed in early-onset colon cancer.SFRP4 is speculated to play an essential role in cancer by inhibiting the epithelial mesenchymal transition(EMT).AIM To investigate the correlation between SFRP4 expression and EMT-linked genes in colon cancer and how it affects patient survival.METHODS SFRP4 expression relative to that of EMT-linked genes and survival analysis were performed using the University of California Santa Cruz Cancer Browser interface.RESULTS SFRP4 was found to be co-expressed with the EMT-linked markers CDH2,FN1,VIM,TWIST1,TWIST2,SNAI1,SNAI2,ZEB1,ZEB2,POSTN,MMP2,MMP7,MMP9,and COL1A1.SFRP4 expression negatively correlated with the EMTlinked suppressors CLDN4,CLDN7,TJP3,MUC1,and CDH1.The expression of SFRP4 and the EMT-linked markers was higher in mesenchymal-like samples compared to epithelial-like samples which potentially implicates SFRP4-EMT mechanism in colon cancer.Additionally,patients overexpressing SFRP4 presented with poor overall survival(P=0.0293).CONCLUSION Considering the implication of SFRP4 in early-onset colon cancer,particularly in the context of EMT,tumor metastasis,and invasion,and the effect of increased expression on colon cancer patient survival,SFRP4 might be a potential biomarker for early-onset colon cancer that could be targeted for diagnosis and/or disease therapy. | Landry E Nfonsam Jana Jandova Hunter C Jecius Pamela N Omesiete Valentine N Nfonsam | 2019 | World Journal of Gastrointestinal Oncology2019，11，8： | 4 |
| 2 | Role of penicillin - binding proteins in the initiation of the AmpC β-lactamase expression in Enterobacter cloacae显示文摘 | Pfeifle D Janas E Wedemann B | 2000 | Antimicrob Agents Chemother2000，44，1： | 1 |
| 3 | Determinants of mi- croRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28 显示文摘 | Piskounova E Viswanathan SR Janas M | 2008 | J Biol Chem2008，283，21： | 1 |
| 4 | Role of pencillin-binding proteins in the initiation of the AmpC β-lactamase expression in Enterobacter cloacae显示文摘 | Pfeifle D Janas E Wiedemann B | 2000 | Antimicrob Agents Chemother2000，44，16： | 1 |
| 5 | Variceal bleeding in portal hypertension: bacterial infection and comparison of efficacy of intravenous and per-oral application of antibiotics – a randomized trial显示文摘 | Jan Lata Jana Juránková Libu?e Husová Michal ?enky?ík Petr Dítě Milan Dastych Veronika P?íbramská Radek Kroupa | 2005 | European Journal of Gastroenterology & Hepatology2005，，10： | 1 |
| 6 | Role of Penicillin-Binding Proteins in the Initiation of the AmpC β-Lactamase Expression in Enterobacter cloacae显示文摘 | PFEIFLE D JANAS E WIEDEMANN B | 2000 | Antimicrob Agents Chemother2000，44，1： | 1 |
| 7 | Stability analysis of simplifysupported rectangular plates under non-uniform uniaxial compression using rigorous and approximate plane stress solutions 显示文摘 | Jana E Bhaskar K | 2006 | Thin-Walled Structures2006，44，5： | 1 |
| 8 | Role of penicillin- binding proteins in the initiation of the AmpCβ - lactamase expression in Enterobactercloacae 显示文摘 | Pfeifle D Janas E Wedemann B | 2000 | Antimicrob Agents Chemother2000，44，1： | 1 |
| 9 | The influence of the initial acidity of HFER on the status of Co species and catalytic performance of CoFER and InCoFER in CH4 - SCR - NO 显示文摘 | Gila B Janas J Woch E | 2008 | Catalysis Today2008，，137： | 1 |
| 10 | Role of Penicillin-Binding Proteins in the Initiation of the AmpC β-Lactamase Expression in Enterobacter cloacae显示文摘 | Pfeifle D Janas E Wiedemann B | 2000 | Antimicrobal Agents and Chemotherapy2000，44，1： | 1 |
| 11 | Contribution of JAM-1 to epi- thelial differentiation and tight-junction biogenesis in the mouse preimplantation embryo显示文摘 | Thomas FC Sheth B Eckert J J Bazzoni G De- jana E Fleming TP | 2004 | J Cell Sci2004，117，23： | 1 |
| 12 | Role of penicillin - binding proteins in the initiation of the AmpC β-lactamase expression in Enterobactercloacae 显示文摘 | Pfeifle D Janas E Wedemann B | 2000 | Antimicrob Agents Chemother2000，44，1： | 1 |
| 13 | The membrane cytoskeletal cross linker ezrin is required for metastasis of breast carcinoma cells 显示文摘 | Bruce E Elliott Jana A Sandi K | 2005 | Breast Cancer Research2005，7，： | 1 |
| 14 | Role of penicillin-binding proteins in the initiation of the AmpC β-lactamase expression in Enterobacter cloacae显示文摘 | Pfeifle D Janas E Wiedemann B | 2000 | Antimicrob Agents Chemother2000，44，1： | 1 |
| 15 | Pancreatic islet inflammation in type 2 diabetes: from alpha and beta cell compensation to dysfunction显示文摘 | JANA E HELGA E MARIANNE B S | 2009 | Archives of Physiology and Biochemistry2009，115，4： | 1 |
| 16 | The epidemiology of child- hood injury in Maputo, Mozambique显示文摘 | DELMIRA P CHRISTINE E JANA B | 2010 | Int J Emerg Med2010，3，3： | 1 |
| 17 | Selective catalytic reduction of nitric oxide over zeolite catalysts in the presence of hydrocarbons and the excess of oxygen 显示文摘 | KUBACKA A JANAS J WLOCH E | 2005 | Catalysts Today2005，101，2： | 1 |
| 18 | Functionalization of gold nanospheres and nanorods by chitosan oligosaccharide derivatives显示文摘 | Nandanan E Jana NR Ying JY | | 0，，11： | 1 |
| 19 | Processing of dense nanostructured HA ceramics by sintering and hot pressing显示文摘 | Veljovi(é)a D j Joki(é)a B Petrovi(é)a R Palcevskisb E Dinduneb A Mihailescuc I N Jana(é)kovi(é)a D j | | 0，，04： | 1 |
| 20 | A time - scale approach for analysis of coalescence in processing flows 显示文摘 | Perilla J E Jana S C | 2004 | Polym Eng Sci2004，44，12： | 1 |
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