|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CA19-9 antigen levels can distinguish between benign and malignant pancreaticobiliary disease显示文摘BACKGROUND:CA19-9 is a carbohydrate tumor-associated antigen which is frequently upregulated in pancreatobiliary neoplasia.However,it may also be elevated in patients with jaundice in the absence of a tumor due to biliary obstruction,and in other non-hepato-pancreatico-biliary conditions.This study aimed to evaluate whether CA19-9 levels could accurately differentiate between benign and malignant pancreatobiliary disease.METHODS:All patients referred to a single surgeon for investigation of pancreaticobiliary disease in 2003 in whom a firm diagnosis had been established were included.For malignant disease,a histological diagnosis was required but for benign disease a firm radiological diagnosis was deemed adequate.The patients were divided into 4 categories:pancreatic adenocarcinoma(PCa);cholangiocarcinoma(CCa);chronic pancreatitis(CP)and biliary calculous disease(Calc).Bilirubin and alkaline phosphatase levels corresponding to the point of assessment of CA19-9 were also noted.RESULTS:Final diagnoses were made of pancreatic adenocarcinoma(PCa,n=73),cholangiocarcinoma(CCa,n=19),ampullary carcinoma(Amp,n=7),neuroendocrine carcinoma(Neu,n=4),duodenal carcinoma(Duo,n=3),chronic pancreatitis(CP,n=115),and biliary calculous disease(Calc,n=27).Median CA19-9 levels(U/ml)were:PCa,653;CCa,408;Duo,403;Calc,27;CP,19;Neu,10.5;Amp,8(reference range:0-37).The CA19-9 levels were significantly greater for malignant than for benign disease,could differentiate PCa from CCa/Duo,and were significantly higher in unresectable than in resectable PCa.The sensitivity,specificity,positive predictive value(PPV)and negative predictive value(NPV)for CA19-9 were 84.9%,69.7%,67.7%and 86.1%,respectively.A ROC analysis provided an area under the curve for CA19-9 of 0.871(0.820-0.922),giving an optimal CA19-9 of 70.5 U/ml for differentiating benign from malignant pathology.Using this cut-off,the sensitivity was 82.1%,while specificity,PPV and NPV improved to 85.9%,81.3%and 86.5%,respectively.When standard radiology was included(US/ CT/MRCP)in the decision process,the results improved to 97.2%,88.7%,86.6%,and 97.7%.For benign disease,the CA19-9 correlated directly with the serum bilirubin,but for malignant disease,CA19-9 levels were elevated independent of the bilirubin level.CONCLUSIONS:CA19-9 is useful in the differentiation of pancreatobiliary disease and when using an optimized cut-off and combining with routine radiology,the diagnostic yield is improved significantly,thus stressing the importance of a multi-disciplinary approach to pancreatobiliary disease. | Gareth Morris-Stiff Mary Teli Nicky Jardine Malcolm CA Puntis | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 33 |
| 2 | Role of terpenes from aphid-infested potato on searching and oviposition behavior of Episyrphus balteatus显示文摘应付病原体和昆虫攻击,植物开发防卫的不同机制,在两个直接(物理、化学) 并且间接方法(到食虫的 beneficials 的吸引人的 volatiles ) 。植物当时能表示由吸引草食动物食肉动物便于害虫的“自顶向下”的控制的特点。这里,我们由分析不稳定的模式调查土豆植物的间接防卫机制健康并且 aphid-infestedplants。在由 Myzus persicae 的射出的萜烯模式的重要变化大批出没于寄植物被观察。用稳固的阶段 MicroExtraction (SPME ) 和 GCMS,(E)-beta-farnesene (EBF ) 看起来被大批出没于蚜虫的土豆并且不由健康植物射出。为了在蚜虫以后估计这些不稳定的版本的 theinfochemical 角色,在 aphidophagous predatorsEpisyrphus balteatus 上损坏, hover 苍蝇 foraging 行为用观察员 5.0 软件被估计(Noldus, Wageningen,荷兰) 。没有蚜虫的土豆植物也被用作控制在食肉动物的不稳定的来源行为的学习。当大批出没于蚜虫的植物导致了有效寻找并且公认字义行为导致时生蛋,健康土豆植物的 kairomonal 效果都没被观察,在网笼子导致更长的不动持续时间和更短的寻找时期。E 的 Highoviposition 率。当大批出没于蚜虫的土豆被使用时, balteatus 被观察(每放并且每 48.9eggs 意味着女性) 。在另一方面,没有鸡蛋被 hover 苍蝇在 healthyaphid 免费的植物上生产。E。balteatus foraging 和繁殖行为在综合蚜虫害虫管理在与 activeinfochemical 分子的潜在的使用的关系根据从大批出没于蚜虫的植物的不稳定的排放被讨论。 | NICOLAS HARMEL RAKI ALMOHAMAD MARIE-LAURE FAUCONNIER PATRICK DU JARDIN FRANCOIS VERHEGGEN MICHEL MARLIER ERIC HAUBRUGE FREDERIC FRANCIS | 2007 | Insect Science2007，14，1： | 11 |
| 3 | Microbial communities biostimulated by ethanol during uranium (VI) bioremediation in contaminated sediment as shown by stable isotope probing显示文摘(啜) 稳定的同位素探查被用来识别乙醇增加在包含在 US 能源部橡树理兹地点从 bioremediation 测试地区收集的二沉积的缩影刺激的微生物, TN,美国。一件样品是高度有乙醇的 bioreduced 当另外一个少些被减少时。有各自的沉积的缩影与标记乙醇并且为啜为 7 孵化了天的 13C 被修改。乙醇很快在伴有硝酸盐和硫酸盐的减小的 24 h 以内被变换成醋酸盐。醋酸盐的累积在远处坚持了 7 d 时期。水的 U 没由于 U 的解吸附作用与减少的沉积在缩影衰退,但是连续地在少些减少的样品衰退。微生物引起的生长和伴随物 < 啜 class= “ a-plus-plus ” > 13 C-DNA 生产被检测乙醇是否是精疲力尽的,丰富的醋酸盐在两个缩影积累了。这在少些减少的样品与 U (VI ) 减小与一致。< 啜 class= “ a-plus-plus ” > 13 从乙醇发源的 C 最终为生长被利用,直接或间接地,由在 7 天孵化以内的主导的微生物引起的社区成员。微生物引起的社区由包括 Desulfovibrio, Sphingomonas, Ferribacterium, Rhodanobacter, Geothrix, Thiobacillus 和其它减少细菌的已知的 denitrifiers,减少硫酸盐的细菌和铁(III ) 主要组成,包括减少细菌 Acidovorax, Anaeromyxobacter, Desulfovibrio, Geobacter 和 Desulfosporosinus 的已知的 U (VI ) 。调查结果建议那乙醇 biostimulates 由首先为硝酸盐,硫酸盐,铁( III )和 U ( VI )用作一个电子施主减少微生物引起的社区的 U ( VI )减小,并且然后为微生物引起的生长为 U ( VI )减小和碳来源作为电子施主工作的醋酸盐。 | Mary Beth LEIGH Wei-Min WU Erick CARDENAS Ondrej UHLIK Sue CARROLL Terry GENTRY Terence L. MARSH Jizhong ZHOU Philip JARDINE Craig S. CRIDDLE James M. TIEDJE | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 5 |
| 4 | Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial显示文摘 | Christian Récher Bertrand Coiffier Corinne Haioun Thierry Jo Molina Christophe Fermé Olivier Casasnovas Catherine Thiéblemont André Bosly Guy Laurent Franck Morschhauser Hervé Ghesquières Fabrice Jardin Serge Bologna Christophe Fruchart Bernadette Corront | 2011 | 2011 (9806)2011，，9806： | 2 |
| 5 | Actual incidence of global left ventricular hypokinesia in adult septic shock显示文摘 | Antoine Vieillard-Baron Vincent Caille Cyril Charron Guillaume Belliard Bernard Page Fran?ois Jardin | 2008 | Critical Care Medicine2008，，6： | 2 |
| 6 | A review on machinery diagnostics and prognostics implementing condition-based maintenance显示文摘 | Andrew K.S. Jardine Daming Lin Dragan Banjevic | 2005 | Mechanical Systems and Signal Processing2005，，7： | 2 |
| 7 | Effect of fluvastatin on cardiac outcomes in renal transplant recipients: a multicentre, randomized, placebo-controlled trial显示文摘 | HOLDAAS H FELLSTROM B JARDINE AG | 2003 | Lancet2003，361，9374： | 1 |
| 8 | DNA damage is able to induce senescence in tumor cells in vitro and in vivo显示文摘 | Te Poele RH Okorokov AL Jardine L | 2002 | Cancer Res2002，62，6： | 1 |
| 9 | From Post-Distortion to Pre-Distortion for Power Amplifiers Linearization显示文摘 | Marsalek R Jardin P Baudoin G | 2003 | Communications Letters2003，7，7： | 1 |
| 10 | Spiral CT angiography of the pulmonary circulation显示文摘 | Remy - Jardin M Remy J | 1999 | Radiology1999，212，： | 1 |
| 11 | Application of liquid chromatography-mass spectrometry (n) analyses to the characterization of novel glyburide metabolites formed in vitro 显示文摘 | Tiller P R Land A P Jardine I | 1998 | J Chromatogr A1998，794，12： | 1 |
| 12 | Rosuvastatin and cardiovascular events in patients undergoing hemodialysis 显示文摘 | FELLSTROM B C JARDINE A G SCHMIEDER RE etal | 2009 | N Engl J Med2009，360，14： | 1 |
| 13 | Brain stem stroke causing baroreflex failure and paroxysmal hypertension显示文摘 | Phillips AM Jardine DL Parkin PJ | | 0，，08： | 1 |
| 14 | Attenuatedimmunochemotherapy regimen (R-miniGHOP) in elderlypatients older than 80 years with diff use large B-celllymphoma: a multicentre, single-arm, phase 2 trial 显示文摘 | Peyrade F Jardin F Thieblemont C | 2011 | Lancet Oncol2011，12，5： | 1 |
| 15 | Decrease in cardiac output and muscle sympathetic activity during vasovagal syncope显示文摘 | Jardine DL Melton IC Crozier IG | 2002 | Am J Physiol Heart Circ Physiol2002，282，： | 1 |
| 16 | Fluvastatin prevents cardiac death and myocardial infarction in renal transplant recipients : post-hoc subgroup analyses of the ALERT study显示文摘 | JARDINE AG HOLDAAS H FELLSTROM B | 2004 | Am J Transplant2004，4，6： | 1 |
| 17 | A replacement model with overhauls and repairs 显示文摘 | Liu X G Makis V Jardine A K S | 1995 | Naval Research Logistics1995，42，7： | 1 |
| 18 | Characterization of the deposition and materials parameters of thin-film TiNi for micro-actuators and smart materials 显示文摘 | JARDINE A P MADSEN J S MERCADO P G | 2004 | Materials characterization2004，32，： | 1 |
| 19 | TSC simulation of ohmic discharges in TFTR显示文摘 | JARDIN S C | 1993 | Nuc1ear Fusion1993，33，3： | 1 |
| 20 | A review on machinery diagnostics and prognostics implementing condition based maintenance 显示文摘 | Jardine A K S Lin D | 2006 | Mechanical Systems and Signal Processing2006，20，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员