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| 1 | Diagnostic endoscopic ultrasonography:Assessment of safety and prevention of complications显示文摘Endoscopic ultrasonography (EUS) has gained wide acceptance as an important, minimally invasive diagnostic tool in gastroenterology, pulmonology, visceral surgery and oncology. This review focuses on data regarding risks and complications of non-interventional diagnostic EUS and EUS-guided fine-needle biopsy (EUS-FNB). Measures to improve the safety of EUS und EUS-FNB will be discussed. Due to the specific mechanical properties of echoendoscopes in EUS, there is a low but noteworthy risk of perforation. To minimize this risk, endoscopists should be familiar with the specific features of their equipment and their patients' specific anatomical situations (e.g., tumor stenosis, diverticula). Most diagnostic EUS complications occur during EUS-FNB. Pain, acute pancreatitis, infection and bleeding are the primary adverse effects, occurring in 1% to 2% ofpatients. Only a few cases of needle tract seeding and peritoneal dissemination have been reported. The mortality associated with EUS and EUS-FNB is 0.02%. The risks associated with EUS-FNB are affected by endoscopist experience and target lesion. EUS-FNB of cystic lesions is associated with an increased risk of infection and hemorrhage. Peri-interventional antibiotics are recommended to prevent cyst infection. Adequate education and training, as well consideration of contraindications, are essential to minimize the risks of EUS and EUS-FNB. Restricting EUS-FNB only to patients in whom the cytopathological results may be expected to change the course of management is the best way of reducing the number of complications. | Christian Jenssen Maria Victoria Alvarez-Sánchez Bertrand Napoléon Siegbert Faiss | 2012 | World Journal of Gastroenterology2012，18，34： | 33 |
| 2 | New ultrasound techniques for lymph node evaluation显示文摘Conventional ultrasound(US)is the recommended imaging method for lymph node(LN)diseases with the advantages of high resolution,real time evaluation and relative low costs.Current indications of transcutaneous ultrasound and endoscopic ultrasound include the detection and characterization of lymph nodes and the guidance for LN biopsy.Recent advances in US technology,such as contrast enhanced ultrasound(CEUS),contrast enhanced endoscopic ultrasound(CE-EUS),and real time elastography show potential to improve the accuracy of US for the differential diagnosis of benign and malignant lymph nodes.In addition,CEUS and CE-EUS have been also used for the guidance of fine needle aspiration and assessment of treatment response.Complementary to size criteria,CEUS could also be used to evaluate response of tumor angiogenesis to anti-angiogenic therapies.In this paper we review current literature regarding evaluation of lymphadenopathy by new and innovative US techniques. | Xin-Wu Cui Christian Jenssen Adrian Saftoiu Andre Ignee Christoph F Dietrich | 2013 | World Journal of Gastroenterology2013，19，30： | 25 |
| 3 | Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase显示文摘Mitogen-activated protein kinases(MAPKs)are a family of proteins that constitute signaling pathways involved in processes that control gene expression,cell division, cell survival,apoptosis,metabolism,differentiation and motility.The MAPK pathways can be divided into conventional and atypical MAPK pathways.The first group converts a signal into a cellular response through a relay of three consecutive phosphorylation events exerted by MAPK kinase kinases,MAPK kinase,and MAPK.Atypical MAPK pathways are not organized into this three-tiered cascade.MAPK that belongs to both conventional and atypical MAPK pathways can phosphorylate both non-protein kinase substrates and other protein kinases.The latter are referred to as MAPK-activated protein kinases.This review focuses on one such MAPK-activated protein kinase,MAPK-activated protein kinase 5(MK5)or p38-regulated/activated protein kinase(PRAK).This protein is highly conserved throughout the animal kingdom and seems to be the target of both conventional and atypical MAPK pathways.Recent findings on the regulation of the activity and subcellular localization,bona fide interaction partners and physiological roles of MK5/PRAK are discussed. | Sergiy Kostenko Gianina Dumitriu Kari Jenssen Lgreid Ugo Moens | 2011 | World Journal of Biological Chemistry2011，2，5： | 8 |
| 4 | 高动态动脉僵硬度指数是普通中年人群年龄相关的肾小球滤过率快速下降的一个独立危险因素显示文摘Eriksen BO, Stefansson VT, Jenssen TG, Mathisen UD, Schei J, Solbu MD, Wilsgaard T, Melsom T. High ambulatory arte- rial stiffness index is an independent risk factor for rapid age-related glomerular filtration rate decline in the general middle- aged population. Hypertension, 2017,69 (4) : 651-659.动脉僵硬度是心血管病及慢性肾脏病的危险因素。流行病学研究难以足够精确测定肾小球滤过率(glomerular filtration rate, GFR),普通人群中,动脉僵硬度做为年龄相关GFR下降的预测因素,作用仍不明确。动态动脉僵硬度指数( ambulatory arterialstiffness index, AASI) 是一个易于从动态血压中计算得到的动脉僵硬度推荐指标。该研究在普通人群中评估AASI是否可预测碘海醇清除率评估的GFR下降。 | Eriksen BO Stefansson VT Jenssen TG Mathisen UD Schei J Solbu MD Wilsgaard T Melsom T 赵狄 练桂丽 | 2017 | 中华高血压杂志2017，25，3： | 8 |
| 5 | 全球气候变化对北极海洋生态系统持久性有机污染物和汞途径及暴露的生态影响研究显示文摘生物累积性和生物放大污染物,如持久性有机污染物(POPs)和汞(Hg),数十年来一直被公认为在北极海洋生物健康的关注。近年来,全球气候变化(GCC)和北极海冰相关损失已观察到驱动大幅改变北极生态系统。本文综述了研究记录的经验之间的联系GCC诱导的流行和在北极海洋生态系统的汞暴露和通路的生态变化和改变。大多数的研究报道在流行或汞浓度变化与GCC引起的物种营养相互作用的变化组织。这些研究通常集中在阿舞的角色变化,栖息地的范围或接近猎物,尤其是在与海冰变化。然而,生态变化,重新适应污染物的趋势变化往往是不清楚或假定。其他的研究已经成功地使用化学示踪剂,如稳定的氮和碳同位素比值和脂肪酸签名连接这样的生态变化,污染物水平的变化或趋势。较低的海冰与饮食变化/变异与较高的污染水平在一些不同的北极熊,以及相关的环斑海豹,和厚嘴默,但改变营养相互作用影响的流行水平和趋势的大小和方向的变化很大。我们建议在这一新领域的GCC链接ECOTOX -生态学的重点应该放在配套的生态指标与流行和汞的研究常规分析未来的研究,同时考虑了GCC和污染物的相互作用可能发生的多种机制,并有针对性地研究变化的暴露和毒性的物种称为敏感的GCC和污染物[现行生态61(4):617-628,2015 ]。 | Melissa A. MCKINNEY Sara PEDRO Rune DIETZ Christian SONNE Aaron T. FISK Denis ROY Bjorn M. JENSSEN Robert J. LETCHER | 2015 | Current Zoology2015，61，4： | 7 |
| 6 | Fortuitously discovered liver lesions显示文摘The fortuitously discovered liver lesion is a common problem. Consensus might be expected in terms of its work-up, and yet there is none. This stems in part from the fact that there is no preventive campaign involving the early detection of liver tumors other than for patients with known liver cirrhosis and oncological patients. The work-up (detection and differential diagnosis) of liver tumors comprises theoretical considerations, history, physical examination, laboratory tests, standard ultrasound, Doppler ultrasound techniques, contrastenhanced ultrasound (CEUS), computed tomography and magnetic resonance imaging, as well as imageguided biopsy. CEUS techniques have proved to be the most pertinent method; these techniques became part of the clinical routine about 10 years ago in Europe and Asia and are used for a variety of indications in daily clinical practice. CEUS is in many cases the first and also decisive technical intervention for detecting and characterizing liver tumors. This development is reflected in many CEUS guidelines, e.g. , in the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) guidelines 2004, 2008 and 2012 as well as the recently published World Federation for Ultrasound in Medicine and Biology-EFSUMB guidelines 2012. This article sets out considerations for making a structured work-up of incidental liver tumors feasible. | Christoph F Dietrich Malay Sharma Robert N Gibson Schreiber-Dietrich Christian Jenssen | 2013 | World Journal of Gastroenterology2013，19，21： | 3 |
| 7 | Serous pancreatic neoplasia, data and review显示文摘AIM To describe the imaging features of serous neoplasms of the pancreas using ultrasound, endoscopic ultrasound, computed tomography and magnetic resonance imaging.METHODS This multicenter international collaboration enhances a literature review to date, reporting features of 287 histologically confirmed cases of serous pancreatic cystic neoplasms(SPN). RESULTS Female predominance is seen with most SPN presenting asymptomatically in the 5th through 7th decade. Mean lesion size was 38.7 mm, 98% were single, 44.2% cystic, 46% mixed cystic and solid, and 94% hypoechoic on B-mode ultrasound. Vascular patterns and contrast-enhancement profiles are described as hypervascular and hyperenhancing.CONCLUSION The described ultrasound features can aid differentiation of SPN from other neoplastic lesions under most circumstances. | Christoph F Dietrich Yi Dong Christian Jenssen Valentina Ciaravino Michael Hocke Wen-Ping Wang Eike Burmester Kathleen Moeller Nathan SS Atkinson Paola Capelli Mirko D’Onofrio | 2017 | World Journal of Gastroenterology2017，23，30： | 3 |
| 8 | Interventional endoscopic ultrasonography: an overview of safety and complications显示文摘 | María Victoria Alvarez-Sánchez Christian Jenssen Siegbert Faiss Bertrand Napoléon | 2014 | Surgical Endoscopy2014，，3： | 2 |
| 9 | EFSUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography. Part 1: Basic Principles and Technology显示文摘 | J. Bamber D. Cosgrove C. Dietrich J. Fromageau J. Bojunga F. Calliada V. Cantisani J.-M. Correas M. D’Onofrio E. Drakonaki M. Fink M. Friedrich-Rust O. Gilja R. Havre C. Jenssen A. Klauser R. Ohlinger A. Saftoiu F. Schaefer I. Sporea F. Piscaglia | 2013 | Ultraschall in Med2013，，02： | 2 |
| 10 | A wide range of medium - sized, highly cationic, α - helical peptides show antiviral activity against Herpes simplex virus 显示文摘 | JENSSEN H ANDERSEN J H MANTZILAS D | 2004 | Antiviral Res2004，64，2： | 1 |
| 11 | A literature network of human genes for high-throughput analysis of gene expression显示文摘 | LAEGREID A KOMOROWSKII J | 2001 | Nature Genetics2001，28，1： | 1 |
| 12 | Technology assessment of wastewater treatment by soil infiltration systems显示文摘 | JENSSEN P D SIEGRIST R L | 1990 | Water Science and Technology1990，22，34： | 1 |
| 13 | Methyl methanesulfonate(MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks 显示文摘 | Lundin C North M Erixon K Walters K Jenssen D Goldmanand SHA Helleday T | 2005 | Nucl Acids Res2005，33，12： | 1 |
| 14 | Phosphorus sorption and chemical characteristics of light weight aggregates-potential filter media in treatment wetlands显示文摘 | Zhu T Jenssen P D M hlum T | 1997 | Water Science and Technology1997，35，5： | 1 |
| 15 | Antimicrobial properties of lactoferrin 显示文摘 | Havard Jenssen Robert E W Hancock | 2009 | Biochimie2009，，91： | 1 |
| 16 | How long do most seizures last? A systematic comparison of seizures recorded in the epilepsy monitoring unit 显示文摘 | Jenssen S Gracely EJ Sperling MR | 2006 | Epilepsia2006，47，9： | 1 |
| 17 | Phosphorous sorption and chemical characteristics of lightweight aggregates (LWA):potential filter media in treatment wetlands显示文摘 | ZHU T JENSSEN P D MACHLUM T | 1997 | Water Sci Tech1997，35，： | 1 |
| 18 | The role of social and human capital among nascent entrepreneurs显示文摘 | Jenssen J I Hoing B | 2003 | Jornal of Business Venturing2003，18，： | 1 |
| 19 | Bovine lactoferrin and laetofen'icin interfere with intracellular trafficking of Herpes sim- plex virus-I 显示文摘 | Man' A K Jenssen H Roshan Moniri M | 2009 | Biochimie2009，，91： | 1 |
| 20 | Board independence and product market competition in Swedish firms显示文摘 | JENSSEN J I | 2004 | Corporate Governance:An International Review2004，，12： | 1 |
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