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| 1 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 2 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 3 | Lethality and centrality in protein networks显示文摘 | Jeong H Mason S P Barabasi A L | 2001 | Nature2001，411，： | 1 |
| 4 | Effects of thawing temperature on the physicochemical properties of pre-dgor frozen chicken breast and leg muscles显示文摘 | YU L H LEE E S JEONG J Y | 2005 | Meat Science2005，71，2： | 1 |
| 5 | Validation of a FEA tire model for vehicle dynamic analysis and full vehicle real time proving ground simulations显示文摘 | Jeong W K John O H | | SAE Paper0，18，： | 1 |
| 6 | Lethality and centrality in protein networks显示文摘 | Jeong H Mason S P Barabasi A L | 2001 | Nature2001，411，6833： | 1 |
| 7 | Functional and oncologic outcomes comparing interfascial and in- trafascial nerve sparing in robot-ssisted laparoscopic radical prostatectomies显示文摘 | Potdevin L colani M Jeong J | 2009 | J Endourol2009，23，： | 1 |
| 8 | Evolution of the socialnetwork of scientific collaborations显示文摘 | Barabási A L Albert R Jeong H | 1999 | Physical A1999，，： | 1 |
| 9 | Induction of Endothelial Apoptosis by 4-Hydroxyhexenal显示文摘 | JI Y L JEONG H J DELLEN H K | 2004 | Eur J Biochem2004，271，： | 1 |
| 10 | Mean-field theory for scale-free random networks显示文摘 | Barabási A L Albert R Jeong H | 1999 | Physica A1999，，272： | 1 |
| 11 | Networks in life: scaling properties and eigenvalue spectra显示文摘 | Farkas I J Derenyi L Jeong H | 2002 | Phys A2002，，314： | 1 |
| 12 | Power-law distribution of the world wide web显示文摘 | BARABASI A L ALBERT R JEONG H | 2000 | Science2000，287，3： | 1 |
| 13 | 显示文摘 | JEONG S SESSLER J L LYNCH V | 2008 | J Am Chem Soc2008，130，： | 1 |
| 14 | Study on macrophage ac- tivation and structural characteristics of purified polysaccharide from the liquid culture broth of Cordyceps militaris显示文摘 | JONG S L JEONG S K DONG P W | 2010 | Carbohydrate Pol- ymers2010，，82： | 1 |
| 15 | Evolution of the Social Network of Scientific Collaboration 显示文摘 | Barabasi A L Jeong H Nada Z | 2002 | Physica A-Statistical Me- chanics and Its Applications2002，311，34： | 1 |
| 16 | Effect of oil shale retorting temperature on shale oil yield and properties显示文摘 | JEONG G N CHEOL H I SOO H C KI B L | 2012 | Fuel2012，95，： | 1 |
| 17 | Application of a stress triaxiality dependent fracture criterion in the finite element analysis of unnotched Charpy specimens 显示文摘 | YU H L JEONG D Y | 2010 | Theoretical and Applied Fracture Mechanics2010，54，1： | 1 |
| 18 | Mean-field theory for scale-free random networks 显示文摘 | Barabdsi A L Albert R Jeong H | 1999 | Physica A1999，272，1： | 1 |
| 19 | Evolution of the social network of scientific collaborations 显示文摘 | Barabi A L Jeong H N6da Z | 2002 | Physica A : Statistical Mechanics and its Applications2002，311，3： | 1 |
| 20 | Free vibrations of tapered piles embedded partially in Winkler type foundations显示文摘 | LEE B K JEONG J S FAN L G JIN T K | 1999 | J Civil Engrg1999，3，2： | 1 |
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