|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3显示文摘AIM: To investigate the inhibitory role and the underlying mechanisms of sorafenib on signal transducer and activator of transcription 3 (STAT3) activity in hepatocellular carcinoma (HCC).METHODS: Human and rat HCC cell lines were treated with sorafenib. Proliferation and STAT3 dephosphorylation were assessed. Potential molecular mechanisms of STAT3 pathway inhibition by sorafenib were evaluated. In vivo antitumor action and STAT3 inhibition were investigated in an immunocompetent orthotopic rat HCC model.RESULTS: Sorafenib decreased STAT3 phosphorylationat the tyrosine and serine residues (Y705 and S727), but did not affect Janus kinase 2 (JAK2) and phosphatase shatterproof 2 (SHP2), which is associated with growth inhibition in HCC cells. Dephosphorylation of S727 was associated with attenuated extracellular signal-regulated kinase (ERK) phosphorylation, similar to the effects of a mitogen-activated protein kinase (MEK) inhibitor U0126, suggesting that sorafenib induced S727 dephosphorylation by inhibiting MEK/ERK signaling. Meanwhile, sorafenib could also inhibit Akt phosphorylation, and both the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and Akt knockdown resulted in Y705 dephosphorylation, indicating that Y705 dephosphorylation by sorafenib was mediated by inhibiting the PI3K/Akt pathway. Finally, in the rat HCC model, sorafenib signifi cantly inhibited STAT3 activity, reducing tumor growth and metastasis.CONCLUSION: Sorafenib inhibits growth and metastasis of HCC in part by blocking the MEK/ERK/STAT3 and PI3K/Akt/STAT3 signaling pathways, but independent of JAK2 and SHP2 activation. | Fang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian ZhouFang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian Zhou, Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai 200032, China Author contributions: Gu FM, Li QL and Gao Q contributed equally to this work Gu FM and Li QL performed the experi- ments and interpretation of the data and statistical analysis Zhou J and Gao Q contributed to the conception and design of the study Gu FM, Gao Q, Li QL and Zhou J wrote the manuscript Jiang JH, Huang XY, Pan JF and Fan J made substantial contri- bution to the design and conception of the study and interpreta- tion of data all authors read and approved the f inal manuscript. | 2011 | World Journal of Gastroenterology2011，17，34： | 18 |
| 2 | The biological function of type I receptors of bone morphogenetic protein in bone显示文摘Bone morphogenetic proteins(BMPs) have multiple roles in skeletal development, homeostasis and regeneration. BMPs signal via type I and type II serine/threonine kinase receptors(BMPRI and BMPRII). In recent decades, genetic studies in humans and mice have demonstrated that perturbations in BMP signaling via BMPRI resulted in various diseases in bone, cartilage, and muscles. In this review, we focus on all three types of BMPRI, which consist of activin-like kinase 2(ALK2, also called type IA activin receptor), activinlike kinase 3(ALK3, also called BMPRIA), and activin-like kinase 6(ALK6, also called BMPRIB). The research areas covered include the current progress regarding the roles of these receptors during myogenesis,chondrogenesis, and osteogenesis. Understanding the physiological and pathological functions of these receptors at the cellular and molecular levels will advance drug development and tissue regeneration for treating musculoskeletal diseases and bone defects in the future. | Shuxian Lin Kathy KH Svoboda Jian Q Feng Xinquan Jiang | 2016 | Bone Research2016，4，2： | 10 |
| 3 | Expression analysis of a-smooth muscle actin and tenascin-C in the periodontal ligament under orthodontic loading or in vitro culture显示文摘α-smooth muscle actin(α-SMA) and tenascin-C are stress-induced phenotypic features of myofibroblasts. The expression levels of these two proteins closely correlate with the extracellular mechanical microenvironment. We investigated how the expression of α-SMA and tenascin-C was altered in the periodontal ligament(PDL) under orthodontic loading to indirectly reveal the intrinsic mechanical microenvironment in the PDL. In this study, we demonstrated the synergistic effects of transforming growth factor-β1(TGF-β1) and mechanical tensile or compressive stress on myofibroblast differentiation from human periodontal ligament cells(h PDLCs). The h PDLCs under higher tensile or compressive stress significantly increased their levels of α-SMA and tenascin-C compared with those under lower tensile or compressive stress. A similar trend was observed in the tension and compression areas of the PDL under continuous light or heavy orthodontic load in rats. During the time-course analysis of expression, we observed that an increase in α-SMA levels was matched by an increase in tenascin-C levels in the PDL under orthodontic load in vivo. The time-dependent variation of α-SMA and tenascin-C expression in the PDL may indicate the time-dependent variation of intrinsic stress under constant extrinsic loading. | Hui Xu Ding Bai L-Bruno Ruest Jian Q Feng Yong-Wen Guo Ye Tian Yan Jing Yao He Xiang-Long Han | 2015 | International Journal of Oral Science2015，7，4： | 5 |
| 4 | Alkaline syenites in eastern Cathaysia (South China): Link to Permian-Triassic transtension显示文摘 | Wang Q Li J W Jian P Zhao Z H Xiong X L Bao Z W Xu J F Li C F Ma J L | 2005 | Emth Planet Sci Lett2005，230，34： | 1 |
| 5 | Effect of power ultrasound on solidification of aluminum A356 alloy显示文摘 | JIAN X XU H MEEK T T HAN Q | 2005 | Materials Letters2005，59，： | 1 |
| 6 | Effect of power ultrasound on solidification of aluminum A356alloy显示文摘 | Jian x Xu H Meek T T Han Q | 2005 | Materials letter2005，，59： | 1 |
| 7 | Enhanced catharanthine production in Ca- tharanthus roseus cell culture by combined elicitor treatment in shake flasks and bioreactors 显示文摘 | Jian Zhao Zhu W Hu Q | 2001 | Enzyme and Microbial Technology2001，28，： | 1 |
| 8 | Late Oligoeene rapid transformations in the South China Sea显示文摘 | Li Q Jian Z Su X | 2005 | Marine Micropaleontology2005，54，12： | 1 |
| 9 | Isolation of a strain of Acidithiobacillus caldus and its role in bioleaching of chalcopyrite显示文摘 | ZHOU Q G BO F BO Z H XI L JIAN G FEI L F HUA C X | 2007 | World Journal of Microbiology and Biotechnology2007，23，9： | 1 |
| 10 | Identification of the function of extracellular polymeric substances(EPS)in denitrifying phosphorus removal sludge in the presence of copper ion显示文摘 | Wang Y Jian Q Shuai Z | 2015 | Water Research2015，73，： | 1 |
| 11 | Criterion for judging the homogeneous and heterogeneous nucleation显示文摘 | Jian Z Y Jie W Q | 2001 | Metall Mater Trans A2001，32，2： | 1 |
| 12 | Matrix metalloproteinase-2 is associated with tenascin-C in calcific aortic stenosis 显示文摘 | Jian B Jones I'L l i Q | 2001 | Am J Patho12001，159，1： | 1 |
| 13 | Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization显示文摘 | Lieben Liesbet Masuyama Ritsuko Torrekens Sophie Van Looveren Riet Schrooten Jan Baatsen Pieter Lafage-Proust Marie-Hélène Dresselaers Tom Feng Jian Q Bonewald Lynda F Meyer Mark B Pike J Wesley Bouillon Roger Carmeliet Geert | 2012 | EN2012，，5： | 1 |
| 14 | Petrogenesis of adakitic porphyries in an extensional tectonic setting, Dexing, South China:Imphcations for the genesis of porphyry copper mineralization 显示文摘 | Wang q Xu J F Jian P | 2006 | Journal of Petrology2006，47，： | 1 |
| 15 | Coupled 3D discrete-continuum numerical modeling of pile penetration in sand显示文摘 | ZI-IOU J JIAN Q ZHANG J | 2012 | Journal of Zhejiang University ScienceA2012，13，1： | 1 |
| 16 | Effects of oxalate and phos- phate on the release of arsenic from contaminated soils and arsenic accumulation in wheat显示文摘 | TAO Y Q ZHANG S Z JIAN W | 2006 | Chemosphere2006，65，8： | 1 |
| 17 | A dynamic chain-like agent genetic algorithm for global numerical optimization and feature selection显示文摘 | ZENG X P LI Y M JIAN Q | 2009 | Neurocomputing2009，72，456： | 1 |
| 18 | Hepcidin1 knockout mice display defects in bone microarchitecture and changes of bone formation markers显示文摘 | Shen GS Yang Q Jian JL | 2014 | Calcif Tissue Int2014，94，： | 1 |
| 19 | Identification of an emerging recombinant cluster in porcine circovirus type 2显示文摘 | Lin C Jian Q N Ying J X | 2012 | Virus Res2012，165，： | 1 |
| 20 | Expression of Common Carp Growth Hormone in the Yeast Pichia pastoris and Growth Stimulation of Juvenile Tilapia (Oreochromis niloticus)显示文摘 | Li Y H Bai J J Jian Q | 2003 | Aquaculture2003，216，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员