3篇
您的检索式：作者名="JIANG Fajun"
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| 1 | Polymorphisms of chemokine receptors and its ligand alleles influencing genetic suscepti-bity to HIV-1 infection in eight ethnic groups in Chinese mainland显示文摘Limited genetic information is available concerning the polymorphisms of HIV-1 resistant genes in indigenous Chinese populations. The aim of this study is to identify the allelic frequencies of the chemokine and chemokine receptor genes in the Chinese mainland. Genomic DNA samples extracted from whole blood of 2318 subjects were analyzed by using PCR or PCR/restriction fragment length polymorphism (RFLP) assays, and further confirmed by direct DNA sequencing. Higher frequencies of mutant CCR2-64I (19.15%-28.79%) and SDF1-3’A (19.10% -29.86%) alleles were found in subjects of 8 ethnic groups in the Chinese mainland. In contrast, the △32 mutation in CCRS gene occurs at a very low frequency (0.0016, n=1287) in Han population. A relatively high frequency of CCR5-wt/△32 heterozygotes was observed in Uygurian and Mongolian populations. No A32 mutation allele was detected in Tibetan and other 4 ethnic groups in Yunnan Province. There was no CCR5-m303 mutation in subjects of any ethnic group in the Chinese | WANG Fusheng JIN lei LIU Mingxu HONG Weiguo SHI Hong LEI Zhouyun WANG Jiming DU Qingyou HOU Jing ZHANG Bing JIANG Jiandong WANG Yue LI Yueqi XU Anlong HUANG Honglian LIU Fajun | 2001 | Chinese Science Bulletin2001，46，12： | 6 |
| 2 | Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor γ显示文摘Peroxisome 激活 proliferator 的受体(PPAR ) 属于 ligand 依赖的抄写因素的原子荷尔蒙受体总科。最近的结果证明了 PPAR 纬的收缩筋例如 troglitazone (TGZ ) ,能禁止房间增长并且支持独立于 PPAR 纬的房间区别。在现在的学习,我们提供 TGZ 可以直接绑在 EGFR 并且触发它发信号和 PPAR 纬的成为主观独立人士的证据。详细研究表明有 TGZ 的延长孵化有效地稀释了由指向受体到 endo-lysosomal 降级机械发信号的 EGFR。尽管细胞外的调整信号的发信号 kinase 小径被 TGZ 短暂地在 EGFR overexpressing 癌症细胞激活,导致 EGF 的 Akt phosphorylation 的抑制很可能说明了 TGZ 在 pharmacologically 可完成的集中引起的肿瘤细胞的生长拘捕。因此,我们提供了显示 TGZ 由支持 EGFR 降级和 attenuating Akt phosphorylation 禁止房间增长的证据的一根新线。 | Xiaoqi Li Xuanming Yang Youli Xu Xuejun Jiang Xin Li Fajun Nan Hong Tang | 2009 | Cell Research2009，19，6： | 2 |
| 3 | Heterotrophic bacteria of the Dapeng Bay in the South China Sea: community structure,abundance,and the relationships of culturablity with environmental factors显示文摘The community composition,abundance and culturablity of heterotrophic bacterioplankton in the Dapeng Bay of the South China Sea were investigated by morphological method,bacterial cultivation and biochemical methods over an annual cycle.Aeromonas and Pseudomonas were the predominant genera among the Gram-negative bacteria.The bacterioplankton abundance fluctuated from 2.07×10 8 to 2.44×10 9 cells/dm 3 ,and culturable bacteria abundance ranged between 0.1×10 6 and 16.07×10 6 CFU/dm 3 .The Culturablity of heterotrophic bacteria ranged between 0.01% and 1.31%.The relationship between bacterial culturablity and the environmental factors was also studied in different sites of the Dapeng Bay.Throughout the bay,a significantly positive relationship was evidenced between bacterial culturability and temperature,meanswhile bacterial culturability was significantly inversely related with salinity.The positive relationship was shown at the central bay while a negative relationship was observed at the bay mouth and there was no significant correlation at top bay between bacterial culturablity and chlorophyll a of sea water.A positive relationship was found between culturability and DIN all the bay,but DIP showed a significantly negative relationship with bacterial culturability only at the mouth of the bay. | JIANG Fajun HU Zhangli HU Chaoqun | 2010 | Acta Oceanologica Sinica2010，29，4： | 1 |
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