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| 1 | Downstaging and resection of hepatocellular carcinoma in patients with extrahepatic metastases after stereotactic therapy显示文摘Background:A combination of tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies with local regional therapy has elicited yield substantial clinical benefits in patients who have hepatocellular carcinoma(HCC)with extrahepatic metastases.Using this treatment strategy to convert HCC patients with extrahepatic metastases from unresectable to resectable has not yet been reported.Methods:Consecutive hepatocellular carcinoma patients with extrahepatic metastases who received first-line therapy with a combination of TKIs and anti-PD-1 antibodies and at least one local regional therapy were analysed.Results:Nine patients with localized disease who received first-line systemic therapy were enrolled.At baseline,all of them had oligometastatic disease,namely,Barcelona Clinic Liver Cancer stage C(or Chinese Liver Cancer stage IIIB).The most common treatment administered was lenvatinib plus anti-PD-1 antibody and transarterial chemoembolization,and the median time span from systemic therapy to surgery was 3.2(IQR,2.8-6.2)months.Three patients achieved a pathological complete response.Six patients underwent laparoscopic surgery,and the other 3 patients underwent open surgery.After a median follow-up of 10.2(IQR,8.6-20.0)months,7 patients survived without disease recurrence,and 2 experienced tumour recurrence.All patients had any-grade AEs,and 55.6%of the patients experienced grade 3 AEs.Fatigue was the most common AE,followed by elevated aminotransferase levels and hypertension.Conclusions:Stereotactic therapy is a feasible conversion therapy for HCC patients with extrahepatic metastases to become resectable.This is the first study to analyse therapeutic outcomes of patients receiving these therapies for HCC with extrahepatic metastases. | Xiaobo Yang Haifeng Xu Bangyou Zuo Xu Yang Jin Bian Junyu Long Dongxu Wang Junwei Zhang Cong Ning Yanyu Wang Ziyu Xun Yunchao Wang Xin Lu Yilei Mao Xinting Sang Haitao Zhao | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 17 |
| 2 | Mechanisms of improvement of left ventricle remodeling by transplanting two kinds of autologous bone marrow stem cells in pigs显示文摘背景在尖锐心肌的梗塞( AMI )以后的很多心肌的房间的坏死导致心脏的功能和移植能改进的室 remodeling.Stem 房间的减少在 AMI 以后的心脏的功能,但是包含的机制一直不是完全学习试图在改变的室上经由冠的动脉调查自体同源的骨头髓 mononuclear 房间( BM-MNC )和 rnesenchymal 干细胞( MSC )的移植的效果的在场的 understood.The 控制组,简单梗塞模型组, BM-MNC 移植组,和 MSC 移植当有 AMI 的一个缩小的猪的模型被建立时, 90 纪录的 group.At ,自体同源的 BM-MNC 的移植(( 4.7ntraoperative ,并且手术后)被评估, compared.The 病态和死亡结果在二 groups.The 后续结果被比较,在二组织的 surgery.Results 与外科手术前的高风险的侧面有病人的类似的百分比以后。 | LI Shu-ren QI Xiao-yong HU Fu-li ZHANG Jian-qing WANG Tian-hong DANG Yi MENG Cun-liang LIU Hui-liang LI Ying-xiao WU Di DONG Jie XUN Li-ying GAO Li-hui JIN Fu-chang | 2008 | Chinese Medical Journal2008，，23： | 12 |
| 3 | Stromal cell derived factor-1 enhances bone marrow mononuclear cell migration in mice with acute liver failure显示文摘AIM:To evaluate the number of bone marrow mononuclear cells(BMMC) that are migrated to the liver following transplantation of murine BMMC into mice with acute liver injury.METHODS:BMMC were isolated from the bone marrow of mice in a lymphocyte separation medium and then labeled with PKH26.The labeled cells were subsequently infused into the caudal veins of BALB/c mice with hepatic injury induced by carbon tetrachloride and 2-acetylaminofluorene.Mice in experimental group were treated with stromal cell-derived factor-1(SDF-1) which was injected intraperitoneally after trans-plantation of BMMC.Mice in control group were injected intraperitoneally with 0.1 mL of saline(0.9% NaCl) after transplantation of BMMC.After 2 wk,migration of the cells in experimental group was studied by fluorescence microscopy.The expression of proliferating cell nuclear antigen and albumin was quantified with manual methods in both groups.The serum transaminase levels at different time points were compared between the two groups.RESULTS:The labeled 'cells' were found in the portalregion and central veins of hepatic lobules.The PKH26-labeled cells appeared at an average frequency of 108 ± 8/high power field in the experiment group and 65 ± 8/high power field in the control group(P < 0.05).The total number of positive cells was 29 ± 7/high power field in the experimental group and 13 ± 2/high power field in the control group.The albumin expres-sion level was also higher in the experimental group than in the control group(29 ± 7 vs 13 ± 2,P < 0.05).The total number of crossing points was 156 ± 5/high power field in the experimental group and 53 ± 5/high power field in the control group(P < 0.05).The serum alanine aminotransferase levels in experimental and control groups were measured at different time points(120 ± 40 vs 118.50 ± 1.75,P > 0.05;80.60 ± 6.50 vs 101.08 ± 5.67,P < 0.05;50.74 ± 5.38 vs 80.47 ± 4.62,P < 0.05;30.54 ± 2.70 vs 60.72 ± 4.37,P < 0.05;30.77 ± 5.36 vs 40.47 ± 6.50,P < 0.05).At the same time,the serum aspartate aminotransferase levels were measured in experimental and control groups at different time points(122.55 ± 1.46 vs 120.70 ± 4.22,P > 0.05;54.26 ± 6.50 vs 98.70 ± 8.20,P < 0.05;39.47 ± 5.39 vs 78.34 ± 4.50,P < 0.05;28.94 ± 2.70 vs 56.44 ± 4.28,P < 0.05;30.77 ± 5.45 vs 42.50 ± 6.28,P < 0.05).CONCLUSION:SDF-1 can promote the migration of BMMC to the liver of mice with acute liver failure. | Shi-Zhu Jin Xiang-Wei Meng Ming-Zi Han Xun Sun Li-Ying Sun Bing-Rong Liu | 2009 | World Journal of Gastroenterology2009，15，21： | 10 |
| 4 | Treatment effects of captopril on non-proliferative diabetic retinopathy显示文摘背景糖尿病的 retinopathy (医生)是 变换diabetes.Angiotensin 的最普通的复杂并发症之一酶禁止者被认为在在现在的学习的 DR.The 目的动物模型阻止并且对待网膜的疾病起一个重要作用是调查变换血管收缩素的酶禁止者的角色( ACEI , captopril )没有或与,在有 non-proliferative DR.Methods 的病人的治疗, 317 打 2 个糖尿病的病人( 88.05 个参加者) | Wang Ning Zheng Zhi Jin Hui-yi Xu Xun | 2012 | Chinese Medical Journal2012，，2： | 9 |
| 5 | Changes in Activities of Glutamine Synthetase during Grain Filling and Their Relation to Rice Quality显示文摘Four japonica rice varieties differed in cooking and eating qualities were used in a pot experiment to study the relationship between the activities of glutamine synthetase during grain filling and rice quality. The activities of glutamine synthetase gradually increased and then declined as a single peak curve in the course of grain filling. The 15th day after heading was a turning point, before which the enzymatic activities in the inferior rice varieties with high protein content were higher than those in the superior rice varietie with low protein content, and after which it was converse. The activity of glutamine synthetase in grain was correlated with the taste meter value, peak viscosity and breakdown negatively at the early stage of grain filling whereas positively at the middle and late stages. Moreover, it was correlated with the protein content of rice grain and setback positively at the early stage and negatively at the middle and late stages. The correlation degree varied with the course of grain filling. From 15 days to 20 days after heading was a critical stage, in which the direction of correlation between the activity of glutamine synthetase and taste meter value and RVA properties of rice changed. | JIN Zheng xun QIAN Chun rong YANG Jing LIU Hai ying PIAO Zhong ze | 2007 | Rice science2007，14，3： | 6 |
| 6 | Residual Fatigue Life Prediction of Ball Bearings Based on Paris Law and RMS显示文摘Paris law can reflect the failure mechanism of materials and is usually used to be a method to predict fatigue life or residual fatigue life.But the variable which can represent the health of machine is hardly measured on line.To a degree,the difficulty of on-line application restricts the scope of application of Paris law.The relationship between characteristic values of vibration signals and the variable in the Paris equation which can describe the health of machine is investigated by taking ball bearings as investigative objects.Based on 6205 deep groove ball bearings as a living example,historical lives and vibration signals are analyzed.The feasibility of describing that variable in the Paris equation by the characteristic value of vibration signals is inspected.After that vibration signals decomposed by empirical mode decomposition(EMD),root mean square(RMS) of intrinsic mode function(IMF) involving fault characteristic frequency has a consistent trend with the diameter of flaws.Based on the trend,two improved Paris models are proposed and the scope of application of them is inspected.These two Paris Models are validated by fatigue residual life data from tests of rolling element bearings and vibration signals monitored in the process of operation of rolling element bearings.It shows that the first improved Paris Model is simple and plain and it can be easily applied in actual conditions.The trend of the fatigue residual life predicted by the second improved Paris model is close to the actual conditions and the result of the prediction is slightly greater than the truth.In conclusion,after the appearance of detectable faults,these improved models based on RMS can predict residual fatigue life on line and a new approach to predict residual fatigue life of ball bearings on line without disturbing the machine running is provided. | XU Dong HUANG Jin'e ZHU Qin CHEN Xun XU Yongcheng WANG Shuang | 2012 | Chinese Journal of Mechanical Engineering2012，25，2： | 6 |
| 7 | Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population显示文摘AIM: To investigate the association between colorectal cancer(CRC) genetic susceptibility variants and esophageal cancer in a Chinese Han population.METHODS: A case-control study was conducted including 360 esophageal cancer patients and310 healthy controls. Thirty-one single-nucleotide polymorphisms(SNPs) associated with CRC risk from previous genome-wide association studies were analyzed. SNPs were genotyped using Sequenom Mass-ARRAY technology, and genotypic frequencies in controls were tested for departure from HardyWeinberg equilibrium using a Fisher's exact test. The allelic frequencies were compared between cases and controls using a χ 2 test. Associations between the SNPs and the risk of esophageal cancer were tested using various genetic models(codominant, dominant,recessive, overdominant, and additive). ORs and95%CIs were calculated by unconditional logistic regression with adjustments for age and sex.RESULTS: The minor alleles of rs1321311 and rs4444235 were associated with a 1.53-fold(95%CI:1.15-2.06; P = 0.004) and 1.28-fold(95%CI: 1.03-1.60;P = 0.028) increased risk of esophageal cancer in the allelic model analysis, respectively. In the genetic model analysis, the C/C genotype of rs3802842 was associated with a reduced risk of esophageal cancer in the codominant model(OR = 0.52, 95%CI:0.31-0.88; P = 0.033) and recessive model(OR =0.55, 95%CI: 0.34-0.87; P = 0.010). The rs4939827C/T-T/T genotype was associated with a 0.67-fold(95%CI: 0.46-0.98; P = 0.038) decreased esophageal cancer risk under the dominant model. In addition,rs6687758, rs1321311, and rs4444235 were associated with an increased risk. In particular, the T/T genotype of rs1321311 was associated with an 8.06-fold(95%CI: 1.96-33.07; P = 0.004) increased risk in the codominant model.CONCLUSION: These results provide evidence that known genetic variants associated with CRC risk confer risk for esophageal cancer, and may bring risk for other digestive system tumors. | Ting-Ting Geng Xiao-Jie Xun Sen Li Tian Feng Li-Ping Wang Tian-Bo Jin Peng Hou | 2015 | World Journal of Gastroenterology2015，21，22： | 6 |
| 8 | Anti-inflammatory effects of a synthetic peptide derived from pigment epithelium-derived factor on H2O2-induced corneal injury in vitro显示文摘 | Lu Yi Feng Jia Yang Lili Tang Hongfeng Jin Ji Xu Xun | 2014 | Chinese Medical Journal2014，，8： | 6 |
| 9 | Activation of Na+/K+-ATPase attenuates high glucose-induced H9c2 cell apoptosis via suppressing ROS accumulation and MAPKs activities bv DRm217显示文摘多糖症在糖尿病是为心肌的 apoptosis 和机能障碍负责的主要因素之一。许多研究证明了在减少的 Na +/K+-ATPase 活动和糖尿病的心肌症之间有一种靠近的关系。然而,高导致葡萄糖的心肌的损害上的直接激活的 Na +/K+-ATPase 的效果仍然是未知的。这里,我们发现了那 DRm217, Na +/K+-ATPases 医生区域特定的 monoclonal 抗体和直接使活跃之物,能阻止高导致葡萄糖的 H9c2 细胞损害,反应的氧种(ROS ) 版本,和 mitochondrial 机能障碍。高葡萄糖处理减少了 Na +/K+-ATPase 活动和增加的细胞内部的 Ca 2+ 铺平,而 DRm217 增加了 Na +/K+-ATPase 活动和减轻的 Ca 2+ 超载。Ca 2+ 超载或关门的钠钙 exchanger (NCX 隧道) 的抑制能颠倒高导致葡萄糖的 ROS 增加和房间损害。另外, DRm217 能显著地稀释高导致葡萄糖的 p38, JNK 和 ERK1/2 phosphorylation,它涉及高导致葡萄糖的房间损害和 ROS 累积。我们的调查结果建议 DRm217 可以在心免于高葡萄糖的有害效果。由特定的 Na +/K+-ATPase 使活跃之物的高导致葡萄糖的心肌的房间损害的预防可以是一种吸引人的治疗学的选择。 | Xiaofei Yan Meng Xun Jing Li Litao Wu Xiaojuan Dou Jin Zheng | 2016 | Acta Biochimica et Biophysica Sinica2016，48，10： | 5 |
| 10 | Review on thermochromic vanadium dioxide based smart coatings: from lab to commercial application显示文摘With an urgent demand of energy efficientcoatings for building fenestrations, vanadium dioxide(VO2)-based thermochromic smart coatings have beenwidely investigated due to the reversible phase transition ofVO2 at a critical transition temperature of 68 ℃, which isaccompanied by the modulation of solar irradiation, espe-cially in the near-infrared region. As for commercialapplications in our daily life, there are still some obstaclesfor VO2-based smart coatings, such as the high phasetransition temperature, optical properties (luminous trans-mittance and solar modulation ability), environmental sta-bility in a long-time period, as well as mass production. Inthis review, recent progress of thermochromic smart coat-ings to solve above obstacles has been surveyed. Mean-while, future development trends have also been given topromote the goal of commercial production of VO2 smartcoatings. | Tian-Ci Chang Xun Cao Shan-Hu Bao Shi-Dong Ji Hong-Jie Luo Ping Jin | 2018 | Advances in Manufacturing2018，6，1： | 5 |
| 11 | Biological applications of copper-containing materials显示文摘Copper is an indispensable trace metal element in the human body,which is mainly absorbed in the stomach and small intestine and excreted into the bile.Copper is an important component and catalytic agent of many enzymes and proteins in the body,so it can influence human health through multiple mechanisms.Based on the biological functions and benefits of copper,an increasing number of researchers in the field of biomaterials have focused on developing novel copper-containing biomaterials,which exhibit unique properties in protecting the cardiovascular system,promoting bone fracture healing,and exerting antibacterial effects.Copper can also be used in promoting incisional wounds healing,killing cancer cells,Positron Emission Tomography(PET)imaging,radioimmunological tracing and radiotherapy of cancer.In the present review,the biological functions of copper in the human body are presented,along with an overview of recent progress in our understanding of the biological applications and development of copper-containing materials.Furthermore,this review also provides the prospective on the challenges of those novel biomaterials for future clinical applications. | Peng Wang Yonghui Yuan Ke Xu Hongshan Zhong Yinghui Yang Shiyu Jin Ke Yang Xun Qi | 2021 | Bioactive Materials2021，6，4： | 5 |
| 12 | Diagnostic and prognostic roles of soluble CD22 in patients with Gram-negative bacterial sepsis显示文摘BACKGROUND: Soluble CD22(sCD22) is a fragment of CD22, a B cell-specific membrane protein that negatively regulates B-cell receptor signaling. To date, sCD22 has only been regarded as a tumor marker of B-cell malignancies. Its expression in infectious diseases has not yet been assessed.METHODS: Serum concentrations of sCD22, procalcitonin(PCT) and interleukin-6(IL-6) were measured by enzymelinked immunosorbent assays in patients with intra-abdominal Gram-negative bacterial infection. Receiver operating characteristic curve analysis was performed to evaluate the diagnostic accuracy of these biomarkers in this type of infection. The correlations between biomarkers and the Acute Physiology and Chronic Health Evaluation(APACHE) II scores were also analyzed.RESULTS: Concentrations of sCD22 were significantly elevated in patients with sepsis and the elevation is correlated with the severity of sepsis. sCD22 was also slightly elevated in patients with non-infected systemic inflammatory response syndrome or local infection. The diagnostic accuracy of sCD22 for sepsis was equivalent to that of PCT or IL-6. In addition, the correlation of sCD22 with APACHE II scores was stronger than that of PCT or IL-6.CONCLUSIONS: Serum sCD22 is a novel inflammatory mediator released during infection. This soluble biomarker plays a potential role in the diagnosis of Gram-negative bacterial sepsis, with a diagnostic accuracy as efficient as that of PCT or IL-6. Furthermore, sCD22 is more valuable to predict the outcomes in patients with sepsis than PCT or IL-6. The present study suggested that sCD22 might be potentially useful in supplementing current criteria for sepsis. | Yi-Nan Jiang Xun Cai Hong-Min Zhou Wei-Dong Jin Min Zhang Yong Zhang Xiao-Xiao Du Zhong-Hua Klaus Chen | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，5： | 4 |
| 13 | U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control study in Chinese population显示文摘在由维持 chromosomal 正直并且阻止染色体的生物变老的一个关键角色结束的 Telomeres 玩熔化。流行病学的研究建议了 telomere 长度的内部个人的差别能影响倾向到多重癌症,但是关于食道的有鳞的房间癌(ESCC ) 的证据仍然是不明确的。几 telomere 在白种人的长度相关的单个核苷酸多型性(TLSNP ) 在染色体宽的协会研究被报导了。然而,在 ESCC 开发的 telomere 长度和 TL-SNPs 的效果是不清楚的。因此,我们进行了盒子控制研究(1045 个 ESCC 案例和 1433 控制) 在中国人口评估在 telomere 长度, TL-SNPs,和 ESCC 风险之间的协会。作为结果, ESCC 案例显示出全面更短的相对 telomere 长度(RTL )( 中部:1.34 ) 比控制(中部:1.50, P < 0.001 ) 。更有趣地,一个明显的非线性的U字形的协会在 RTL 和 ESCC 风险之间被观察( P < 0.001 )与比率(95%信心间隔)等于到 2.40 的机会( 1.843.14 ), 1.36 ( 1.031.79 ), 1.01 ( 0.761.35 ),并且 1.37 ( 1.031.82 )为个人在第一(最短),第二,第三,并且 第5 (最长) quintile 分别地,在是的 第4 quintile 与那些相比引用组。没有重要协会在八报导 TL-SNPs 和 ESCC 危险性之间被观察。这些调查结果建议短或极其长的 telomeres 可以是为在中国人口的 ESCC 的风险因素。 | Jiangbo Du Wenjie Xue Yong Ji Xun Zhu Yayun Gu Meng Zhu Cheng Wang Yong Gao Juncheng Dai Hongxia Ma Yue Jiang Jiaping Chen Zhibin Hu Guangfu Jin Hongbing Shen | 2015 | Frontiers of Medicine2015，9，4： | 4 |
| 14 | TILA-TACE – an approach for effective local control of hepatocellular carcinoma显示文摘INTRODUCTION HCC is the sixth common cancer but the third leading cause of cancer-related death(1).More than50%of all HCC patients worldwide are from China alone.The incidence rate of HCC is nearly equal to the mortality rate(1),indicating a highly unmet medical need.Most HCC patients at first diagnosis are already at the BCLC(Barcelona Clinic Liver Cancer Staging Classification)stage B or C,not suitable for curative therapy including surgery,ablation,and liver transplantation. | Ming Chao Hao Wu Kai Jin Xun Hu | 2018 | Journal of Interventional Medicine2018，1，1： | 4 |
| 15 | The SSA-BP-based potential threat prediction for aerial target considering commander emotion显示文摘The target's threat prediction is an essential procedure for the situation analysis in an aerial defense system.However,the traditional threat prediction methods mostly ignore the effect of commander's emotion.They only predict a target's present threat from the target's features itself,which leads to their poor ability in a complex situation.To aerial targets,this paper proposes a method for its potential threat prediction considering commander emotion(PTP-CE)that uses the Bi-directional LSTM(BiLSTM)network and the backpropagation neural network(BP)optimized by the sparrow search algorithm(SSA).Furthermore,we use the BiLSTM to predict the target's future state from real-time series data,and then adopt the SSA-BP to combine the target's state with the commander's emotion to establish a threat prediction model.Therefore,the target's potential threat level can be obtained by this threat prediction model from the predicted future state and the recognized emotion.The experimental results show that the PTP-CE is efficient for aerial target's state prediction and threat prediction,regardless of commander's emotional effect. | Xun Wang Jin Liu Tao Hou Chao Pan | 2022 | Defence Technology(防务技术)2022，18，11： | 3 |
| 16 | Synthesis of Glucoside Bonded Metal Porphyrins显示文摘The reactions of 5,10,15,20-tetrakis(p-hydroxyphenyl) porphyrin 1 and 5-(p-hydroxy-phenyl)-10,15,20-tris(p-methoxyphenyl) porphyrin 2 with 1-bromo -2,3,4,6-O-acetyl-(-D- glu-coside 3 respectively afforded 5,10,15,20-tetrakis[p- (2,3,4,6-O-acetyl-glucoside)-1-O-phenyl] porphyrin 4 and 5,10,15-tris (p-methoxyphenyl) -20-[p-(2,3,4,6-O-acetyl-glucoside)-1-O-phenyl] porphyrin 5. Their metal complexes Co^II(4), Mn^II (4) and Co^II(5), Mn^II(5) also have been prepared. These new compounds have been identified by IR, UV-visible, 1H NMR spectra and elemental analysis. | Zao Ying LI*, Xun Jin ZHU, Li LI, Yue Ning ZHANG Department of Chemistry, Wuhan University, Wuhan 430072 | 2001 | Chinese Chemical Letters2001，12，5： | 3 |
| 17 | Thermodynamic and economic analyses of a coal and biomass indirect coupling power generation system显示文摘The coal and biomass coupling power genera-tion technology is considered as a promising technology for energy conservation and emission reduction.In this paper,a novel coal and biomass indirect coupling system is proposed based on the technology of biomass gasification and co-combustion of coal and gasification gas.For the sake of comparison,a coal and biomass direct coupling system is also introduced based on the technology of co-combustion of coal and biomass.The process of the direct and the indirect coupling system is simulated.The thermodynamic and economic performances of two systems are analyzed and compared.The simulation indicates that the thermodynamic performance of the indirect coupling system is slightly worse,but the economic performance is better than that of the direct coupling system.When the blending ratio of biomass is 20%,the energy and exergy fficiencies of the indirect coupling system are 42.70%and 41.14%,the intemal rate of returm(IRR)and discounted payback period(DPP)of the system are 25.68%and 8.56 years.The price fluctuation of fuels and products has a great influence on the economic performance of the indirect coupling system.The environmental impact analysis indicates that the indirect coupling system can inhibit the propagation of NOx and reduce the environmental cost. | Buqing YE Rui ZHANG Jin CAO Bingquan SHI Xun ZHOU Dong LIU | 2020 | Frontiers in Energy2020，14，3： | 3 |
| 18 | Lactate dehydrogenases amplify reactive oxygen species in cancer cells in response to oxidative stimuli显示文摘Previous studies demonstrated that superoxide could initiate and amplify LDH-catalyzed hydrogen peroxide production in aqueous phase,but its physiological relevance is unknown.Here we showed that LDHA and LDHB both exhibited hydrogen peroxide-producing activity,which was significantly enhanced by the superoxide generated from the isolated mitochondria from HeLa cells and patients'cholangiocarcinoma specimen.After LDHA or LDHB were knocked out,hydrogen peroxide produced by Hela or 4T1 cancer cells were significantly reduced.Re-expression of LDHA in LDHA-knockout HeLa cells partially restored hydrogen peroxide production.In HeLa and 4T1 cells,LDHA or LDHB knockout or LDH inhibitor FX11 significantly decreased ROS induction by modulators of the mitochondrial electron transfer chain(antimycin,oligomycin,rotenone),hypoxia,and pharmacological ROS inducers piperlogumine(PL)and phenethyl isothiocyanate(PEITC).Moreover,the tumors formed by LDHA or LDHB knockout HeLa or 4T1 cells exhibited a significantly less oxidative state than those formed by control cells.Collectively,we provide a mechanistic understanding of a link between LDH and cellular hydrogen peroxide production or oxidative stress in cancer cells in vitro and in vivo. | Hao Wu Yuqi Wang Minfeng Ying Chengmeng Jin Jiangtao Li Xun Hu | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 2 |
| 19 | Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes显示文摘The vagina contains at least a billion microbial cells,dominated by lactobacilli.Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age,as well as cervical,fecal,and salivary samples from a second cohort of 632 women.Factors such as pregnancy history,delivery history,cesarean section,and breastfeeding were all more important than menstrual cycle in shaping the microbiome,and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data.Greater proportion of Bifidobacterium breve was seen with older age at sexual debut.The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history.Potential markers for lack of menstrual regularity,heavy flow,dysmenorrhea,and contraceptives were also identified.Lactobacilli were rare during breastfeeding or post-menopause.Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome.Gut and salivary microbiomes,plasma vitamins,metals,amino acids,and hormones showed associations with the vagino-cervical microbiome.Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth. | Zhuye Jie Chen Chen Lilan Hao Fei Li Liju Song Xiaowei Zhang Jie Zhu Liu Tian Xin Tong Kaiye Cai Zhe Zhang Yanmei Ju Xinlei Yu Ying Li Hongcheng Zhou Haorong Lu Xuemei Qiu Qiang Li Yunli Liao Dongsheng Zhou Heng Lian Yong Zuo Xiaomin Chen Weiqiao Rao Yan Ren Yuan Wang Jin Zi Rong Wang Na Liu Jinghua Wu Wei Zhang Xiao Liu Yang Zong Weibin Liu Liang Xiao Yong Hou Xun Xu Huanming Yang Jian Wang Karsten Kristiansen Huijue Jia | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 2 |
| 20 | Study on Synthesis and Biological Activities of Novel Water-Soluble Metalloporphyrins显示文摘The synthesis and characterization of a series of metal porphyrins, M II (Por), {Por = dianionic of 5,10,15,20 tetrakis[4 (4’ bromobutyloxy)phenyl]porphyrinato and 5,10,15,20 tetrakis[4 (4’ butyloxypyridine bromide)phenyl] porphyrinato, M = Zn, Cu, Mn, Co, Ni, Ru CO} were described. The complexes 3a 3e were prepared from the reactions of compound 2 with metal acetates in chloroform, and the treatment of 3a 3f with excess of pyridine gave corresponding complexes 4a 4f. These new compounds were identified by absorption spectroscopies, 1H NMR and elemental analyses. The results of biological activity testing for 4a 4f revealed that 4a and 4c had stronger inhibiting action on the growth metabolism of Esche richia coli. | Li Zao-ying, Zhang Yue ning, Xiao Wei, Zhu Xun jin,Gao Zhen ting, Liu Yi College of Chemistry and Molecular Science, Wuhan University, Wuhan, 430072, China | 2001 | Wuhan University Journal of Natural Sciences2001，6，4： | 2 |
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