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| 1 | Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes显示文摘The vagina contains at least a billion microbial cells,dominated by lactobacilli.Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age,as well as cervical,fecal,and salivary samples from a second cohort of 632 women.Factors such as pregnancy history,delivery history,cesarean section,and breastfeeding were all more important than menstrual cycle in shaping the microbiome,and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data.Greater proportion of Bifidobacterium breve was seen with older age at sexual debut.The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history.Potential markers for lack of menstrual regularity,heavy flow,dysmenorrhea,and contraceptives were also identified.Lactobacilli were rare during breastfeeding or post-menopause.Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome.Gut and salivary microbiomes,plasma vitamins,metals,amino acids,and hormones showed associations with the vagino-cervical microbiome.Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth. | Zhuye Jie Chen Chen Lilan Hao Fei Li Liju Song Xiaowei Zhang Jie Zhu Liu Tian Xin Tong Kaiye Cai Zhe Zhang Yanmei Ju Xinlei Yu Ying Li Hongcheng Zhou Haorong Lu Xuemei Qiu Qiang Li Yunli Liao Dongsheng Zhou Heng Lian Yong Zuo Xiaomin Chen Weiqiao Rao Yan Ren Yuan Wang Jin Zi Rong Wang Na Liu Jinghua Wu Wei Zhang Xiao Liu Yang Zong Weibin Liu Liang Xiao Yong Hou Xun Xu Huanming Yang Jian Wang Karsten Kristiansen Huijue Jia | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 2 |
| 2 | Cervicovaginal microbiome dynamics after taking oral probiotics显示文摘The vaginal microbiota is less complex than the gut microbiota,and the colonization of Lactobacillus in the female vagina is considered to be critical for reproductive health.Oral probiotics have been suggested as promising means to modulate vaginal homeostasis in the general population.In this study,60 Chinese women were followed for over a year before,during,and after treatment with the probiotics Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14.Shotgun metagenomic data of 1334 samples from multiple body sites did not support a colonization route of the probiotics from the oral cavity to the intestinal tract and then to the vagina.Our analyses enable the classification of the cervicovaginal microbiome into a stable state and a state of dysbiosis.The microbiome in the stable group steadily maintained a relatively high abundance of Lactobacilli over one year,which was not affected by probiotic intake,whereas in the dysbiosis group,the microbiota was more diverse and changed markedly over time.Data from a subset of the dysbiosis group suggests this subgroup possibly benefited from supplementation with the probiotics,indicating that probiotics supplementation can be prescribed for women in a subclinical microbiome setting of dysbiosis,providing opportunities for targeted and personalized microbiome reconstitution. | Chen Chen Lilan Hao Zhe Zhang Liu Tian Xiaowei Zhang Jie Zhu Zhuye Jie Xin Tong Liang Xiao Tao Zhang Xin Jin Xun Xu Huanming Yang Jian Wang Karsten Kristiansen Huijue Jia | 2021 | Journal of Genetics and Genomics2021，48，8： | 1 |
| 3 | The effect of different gravity fields on mass transfer in the rat bone lacunar-canalicular system显示文摘The bone lacunar-canalicular system(LCS)is an important microscopic infrastructure for signaling and solute transport in bone tissue,which guarantees normal physiological processes of the tissue,but the mass transfer laws in the LCS under different gravity fields have not yet been clarified.SD rats were injected intraperitoneally with different concentrations of sodium fluorescein tracer and subjected to mass transfer experiments in the LCS under normal gravity and hypergravity.The fluorescence distribution in the osteon was observed using laser scanning confocal microscopy.The hypergravity environment was provided by a self-designed high-G loading centrifuge.The fluorescence intensity of the Haversian canal in the osteon was the highest.The fluorescence intensity of lacunae farther away from the Haversian canal was lower,and the fitted curve was parabolic.With the increasing distance from the Haversian canal,the curve first rapidly decreased,and then the decreasing trend gradually became slower.Hypergravity promoted mass transfer in the LCS,and the 10 G hypergravity showed varying degrees of fluorescence intensity in each layer of the osteon relative to normal gravity,with intensity enhancements in the range of 132.7–249.0%.The fluorescence intensity was also significantly increased when the tracer concentration was halved and the gravity field magnitude was increased to 10G.In conclusion,hypergravity promoted the transport of solute molecules,nutrients,and signaling molecules within the LCS.The effect of hypergravity on mass transfer in the LCS was greater than that of tracer concentration.This may help to understand bone diseases from a mass transfer perspective. | Hao Wang Jiaming Wang Kangning Li Lilan Gao Aiguo Wang Shuping Wei Linwei Lyu Chunqiu Zhang | 2023 | Medicine in Novel Technology and Devices2023，，1： | 0 |
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