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| 1 | Relationship of Helicobacterpylori eradication with gastric cancer and gastric mucosal histological changes: a 10-year follow-up study显示文摘 | Zhou Liya Lin Sanren Ding Shigang Huang Xuebiao Jin Zhu Cui Rongli Meng Lingmei Li Yuan Zhang Li Guo Changji Xue Yan Yan Xiu'e Zhang Jing | 2014 | Chinese Medical Journal2014，，8： | 28 |
| 2 | In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells显示文摘Adipose-derived stem cells and bone marrow-derived stromal stem cells were co-cultured with untreated or Aβ1-40-treated PC12 cells, or grown in supernatant derived from untreated or Aβ1-40-treated PC12 cells. Analysis by western blot and quantitative real-time PCR showed that protein levels of Nanog, Oct4, and Sox2, and mRNA levels of miR/125a/3p were decreased, while expression of insulin-like growth factor-2 and neuron specific enolase was increased. In comparison, the generation of neuron specific enolase-positive cells was most successful when adipose-derived stem cells were co-cultured with Aβ1-40-treated PC12 cells. Our results demonstrate that adipose-derived stem cells and bone marrow-derived stromal stem cells exhibit trends of neuronal-like cell differentiation after co-culture with Aβ1-40-treated PC12 cells. This process may relate to a downregulation of miR-125a-3p mRNA expression and increased levels of insulin-like growth factor-2 expression. | Jin Zhou Guoping Tian Jing'e Wang Xuefeng Cong Xingkai Wu Siyang Zhang Li Li Bing Xu Feng Zhu Xuedan Luo Jian Han Fengjie Hu | 2011 | Neural Regeneration Research2011，6，19： | 21 |
| 3 | Pupillary response in patients receiving intrathecal sufentanil显示文摘Pupillary constriction occurs with intravenousadministration of opioids such as sufentanil.However,few studies have investigated the pupillaryeffects of intrathecal(IT)sufentanil.It has previouslybeen demonstrated that the cephalad spread within thecerebrospinal fluid of IT sufentanil results in sideeffects.There are two principal findings of the presentstudy:(1)spinal sufentanil combined with low-dose ofbupivacaine in patients with lower abdominal or lowerextremity procedures induces a dose-dependent pupillaryconstriction that is far more sensitive than othercentrally-mediated side effects;(2)the pupillary effect ofIT sufentanil correlates closely with the adequacy ofspinal anesthesia. | WANG Yi-chun GUO Qu-lian WANG E ZHONG Tao HUANG Chang-sheng PENG Jing | 2007 | Chinese Medical Journal2007，，14： | 14 |
| 4 | Changes in retinal and choroidal morphology after cerebrospinal fluid pressure reduction: a Beijing iCOP study显示文摘Dear Editor,Glaucoma is a multifunctional neurodegenerative disease and is the leading cause of irreversible blindness. It is characterized by progressive loss of retinal ganglion cells and their axons leading to visual field defects. | Lu Liu Xiaoxia Li Hanspeter E Killer Kai Cao Jing Li Ningli Wang | 2019 | Science China(Life Sciences)2019，62，2： | 7 |
| 5 | Dasycarine, a New Quinoline Alkaloid from Dictamnus dasycarpus显示文摘Dasycarine, a new quinoline alkaloid along with five known compounds, dictamine, dihydroobacunone, obacunone, fraxinellone and β-sitosterol, were isolated from Dictamnus dasycarpus. The structure of dasycarine was identified as 4, 5, 8- trimethoxyl -3- (3- methyl -2- butenyl)- 2- quinone by 1D and 2D NMR techniques. | Jin CHEN Jing Sheng TANG Jun TIAN You Ping WANG Feng E WU | 2000 | Chinese Chemical Letters2000，11，8： | 7 |
| 6 | F-box protein AFB4 plays a crucial role in plant growth, development and innate immunity显示文摘 | Zhubing Hu Mehmet Ali Kegeli Maria Piisila Jing Li Mantas Survila Pekka Heino Gtinter Brade E Tapio Palva | 2012 | Cell Research2012，22，4： | 7 |
| 7 | Toxicity of Graphene Quantum Dots in Zebrafish Embryo显示文摘Objective To evaluate the bio-safety of graphene quantum dots(GQDs), we studied its effects on the embryonic development of zebrafish. Methods In vivo, biodistribution and the developmental toxicity of GQDs were investigated in embryonic zebrafish at exposure concentrations ranging from 12.5-200 μg/m L for 4-96 h post-fertilization(hpf). The mortality, hatch rate, malformation, heart rate, GQDs uptake, spontaneous movement, and larval behavior were examined. Results The fluorescence of GQDs was mainly localized in the intestines and heart. As the exposure concentration increased, the hatch and heart rate decreased, accompanied by an increase in mortality. Exposure to a high level of GQDs(200 μg/mL) resulted in various embryonic malformations including pericardial edema, vitelline cyst, bent spine, and bent tail. The spontaneous movement significantly decreased after exposure to GQDs at concentrations of 50, 100, and 200 μg/mL. The larval behavior testing(visible light test) showed that the total swimming distance and speed decreased dose-dependently. Embryos exposed to 12.5 μg/mL showed hyperactivity while exposure to higher concentrations(25, 50, 100, and 200 μg/mL) caused remarkable hypoactivity in the light-dark test. Conclusion Low concentrations of GQDs were relatively non-toxic. However, GQDs disrupt the progression of embryonic development at concentrations exceeding 50 μg/mL. | WANG Zhen Guo ZHOU Rong JIANG Dan SONG Jing E XU Qian SI Jing CHEN Yun Ping ZHOU Xin GAN Lu LI Jian Zhen ZHANG Hong LIU Bin | 2015 | Biomedical and Environmental Sciences2015，28，5： | 6 |
| 8 | Variation in the methods leads to variation in the interpretation of biodiversity-ecosystem multifunctionality relationships显示文摘生物多样性常常和生态系统多功能性(生态系统同时提供多个生态系统功能的能力)正相关。然而,生物多样性与生态系统多功能性的关系是否依赖于生态系统功能的数目有诸多争议。其中,生物多样性对生态系统多功能性的影响或许不随生态系统功能数目的变化而变化,或者随生态系统功能数目的增多而增强。我们期望通过研究不同生态系统多功能性指数的统计原理来解决这些争议。我们使用了模型模拟和一系列来自不同空间尺度(从局域到全球)和不同生物群系(温带和高寒草地、森林和干旱地)的经验数据。我们回顾了量化生态系统多功能性的三种方法,包括平均值法、加和法和阈值法。我们发现随着生态系统功能数目的增加,生物多样性与生态系统多功能性的关系要么不变,要么增强。这些结果可由平均和加和的多功能性指数的统计原理来解释。具体来讲,当利用生态系统功能的平均值计算多功能性指数时,由于多样性对多功能性的效应等于多样性对单个生态系统功能效应的平均值,所以不会随生态系统功能数目的变化而变化。同样的道理,当利用单个生态系统的加和值计算多功能性指数时,多样性的效应会随着生态系统功能数目的增加而增强。我们提出了一个改进的多功能性指数,将平均或加和多功能性指数转化为标准化的多功能性指数,以便于对不同研究的结果进行比较。此外,我们提出了基于变量数值范围的标准化方法来解决阈值法的数学假象问题(多样性效应随生态系统功能数目的增加而增强)。我们的研究结果表明,量化多功能性指数的方法不同,结果也不同。因此,有必要加深对不同方法数理基础的理解。而标准化的多功能性指数为比较不同研究中的生物多样性与生态系统多功能性的关系提供了有效的方法。 | Xin Jing Case M.Prager Aimée T.Classen Fernando T.Maestre Jin-Sheng He Nathan J.Sanders | 2020 | Journal of Plant Ecology2020，13，4： | 5 |
| 9 | Prognostic value of perioperative leukocyte count in resectable gastric cancer显示文摘AIM: To investigate the prognostic significance of perioperative leukopenia in patients with resected gastric cancer.METHODS: A total of 614 eligible gastric cancer patients who underwent curative D2 gastrectomy and adjuvant chemotherapy were enrolled in this study. The relationship between pre- and postoperative hematologic parameters and overall survival was assessed statistically, adjusted for known prognostic factors.RESULTS: The mean white blood cell count(WBC) significantly decreased after surgery, and 107/614(17.4%) patients developed p-leukopenia, which was defined as a preoperative WBC ≥ 4.0 × 109/L and postoperative WBC < 4.0 × 109/L, with an absolute decrease ≥ 0.5 × 109/L. The neutrophil count decreased significantly more than the lymphocyte count. P-leukopenia significantly correlated with poor tumor differentiation and preoperative WBC. A higher preoperative WBC and p-leukopenia were independent negative prognostic factors for survival [hazard ratio(HR) = 1.602, 95% confidence interval(CI): 1.185-2.165; P = 0.002, and HR = 1.478, 95%CI: 1.149-1.902; P = 0.002, respectively] after adjusting for histology, Borrmann type, p TNM stage, vascular or neural invasion, gastrectomy method, resection margins, chemotherapy regimens, and preoperative WBC count. The patients with both higher preoperative WBC and p- leukopenia had a worse prognosis compared to those with lower baseline WBC and no p-leukopenia(27.5 mo vs 57.3 mo, P < 0.001). CONCLUSION: Preoperative leukocytosis alone or in combination with postoperative leukopenia could be independent prognostic factors for survival in patients with resectable gastric cancer. | Xiao-Feng Chen Jing Qian Dong Pei Chen Zhou Oluf Dimitri R?e Fang Zhu Shao-Hua He Ying-Ying Qian Yue Zhou Jun Xu Jin Xu Xiao Li Guo-Qiang Ping Yi-Qian Liu Ping Wang Ren-Hua Guo Yong-Qian Shu | 2016 | World Journal of Gastroenterology2016，22，9： | 4 |
| 10 | Correlation of vascular endothelial growth factor to permeability of blood-brain barrier and brain edema during high-altitude exposure显示文摘BACKGROUND:Many studies have evaluated the role of vascular endothelial growth factor(VEGF) in traumatic brain edema and hemorrhagic brain edema. OBJECTIVE:To observe the effects of VEGF expression on permeability of the blood-brain barrier (BBB) during high-altitude and hypoxia exposure,and to investigate the correlation between VEGF expression and BBB permeability with regard to Evans blue staining and brain edema during high-altitude exposure. DESIGN,TIME AND SETTING:The randomized,controlled,animal study was performed at the Tanggula Etape,Central Laboratory of Chengdu Medical College,and Central Laboratory of General Hospital of Chengdu Military Area Command of Chinese PLA,China,from July 2003 to November 2004. MATERIALS:Quantitative RT-PCR kit(Sigma,USA),VEGF ELISA kit(Biosource,USA),and Evans blue(Jingchun,China) were acquired for this study. METHODS:A total of 180 Wistar rats were equally and randomly assigned to 15 groups:low-altitude (500 m),middle-altitude(2 880 m),high-altitude(4 200 m),super-high-altitude(5 000 m),1,3,5,7,9, 11,13,15,17,19,and 21 days of super high-altitude exposure.Wistar rats were exposed to various altitude gradients to establish a hypoxia model. MAIN OUTCOME MEASURES:Brain water content was calculated according to the wet-to-dry weight ratio.BBB permeability to Evans blue was determined by colorimetric method.VEGF mRNA and protein levels in brain tissues were detected using RT-PCR and double-antibody sandwich ELISA. RESULTS:Brain water content,BBB permeability to Evans blue,and VEGF mRNA and protein levels in brain tissues increased with increasing altitude and prolonged exposure to altitude.The greatest increase was determined on day 9 upon ascending 5 000 m.Simultaneously,VEGF expression positively correlated to BBB permeability of Evans blue and brain water content(r = 0.975,0.917,P<0.01). CONCLUSION:Increased VEGF protein and mRNA expression was responsible for increased BBB permeability,which may be an important mechanism underlying brain edema during high-altitude exposure. | Qiquan Zhou Chang'e Liu Jing Wang Yunli Wang Bo Zhou | 2009 | Neural Regeneration Research2009，4，10： | 4 |
| 11 | Therapeutics administered during ex vivo liver machine perfusion:An overview显示文摘Although the use of extended criteria donors has increased the pool of available livers for transplant,it has also introduced the need to develop improved methods of protection against ischemia-reperfusion injury(IRI),as these'marginal'organs are particularly vulnerable to IRI during the process of procurement,preservation,surgery,and post-transplantation.In this review,we explore the current basic science research investigating therapeutics administered during ex vivo liver machine perfusion aimed at mitigating the effects of IRI in the liver transplantation process.These various categories of therapeutics are utilized during the perfusion process and include invoking the RNA interference pathway,utilizing defatting cocktails,and administering classes of agents such as vasodilators,anti-inflammatory drugs,human liver stem cell-derived extracellular vesicles,and δ-opioid agonists in order to reduce the damage of IRI.Ex vivo machine perfusion is an attractive alternative to static cold storage due to its ability to continuously perfuse the organ,effectively deliver substrates and oxygen required for cellular metabolism,therapeutically administer pharmacological or cytoprotective agents,and continuously monitor organ viability during perfusion.The use of administered therapeutics during machine liver perfusion has demonstrated promising results in basic science studies.While novel therapeutic approaches to combat IRI are being developed through basic science research,their use in clinical medicine and treatment in patients for liver transplantation has yet to be explored. | Julianna E Buchwald Jing Xu Adel Bozorgzadeh Paulo N Martins | 2020 | World Journal of Transplantation2020，10，1： | 3 |
| 12 | Preparation and hybridization analysis of DNA/RNA from E. coli on microfabricated bioelectronic chips显示文摘 | Cheng Jing Sheldon E L Wu Lei Uribe A Gerrue L O Carrino J Heller M J O'Connell J P | | 0，，： | 2 |
| 13 | Neuronal differentiation of adipose-derived stem cells and their transplantation for cerebral ischemia显示文摘OBJECTIVE:To review published data on the biological characteristics,differentiation and applications of adipose-derived stem cells in ischemic diseases.DATA RETRIEVAL:A computer-based online search of reports published from January 2005 to June 2012 related to the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia was performed in Web of Science using the key words 'adipose-derived stem cells','neural-like cells','transplantation','stroke',and 'cerebral ischemia'.SELECTION CRITERIA:The documents associated with the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia were selected,and those published in the last 3-5 years or in authoritative journals were preferred in the same field.Totally 89 articles were obtained in the initial retrieval,of which 53 were chosen based on the inclusion criteria.MAIN OUTCOME MEASURES:Biological characteristics and induced differentiation of adipose-derived stem cells and cell transplantation for disease treatment as well as the underlying mechanism of clinical application.RESULTS:The advantages of adipose-derived stem cells include their ease of procurement,wide availability,rapid expansion,low tumorigenesis,low immunogenicity,and absence of ethical constraints.Preclinical experiments have demonstrated that transplanted adipose-derived stem cells can improve neurological functions,reduce small regions of cerebral infarction,promote angiogenesis,and express neuron-specific markers.The improvement of neurological functions was demonstrated in experiments using different methods and time courses of adipose-derived stem cell transplantation,but the mechanisms remain unclear.CONCLUSION:Further research into the treatment of ischemic disease by adipose-derived stem cell transplantation is needed to determine their mechanism of action. | Guoping Tian Jin Zhou Jing'e Wang Bing Xu Li Li Feng Zhu Jian Han Jianping Li Siyang Zhang Xiaoguang Luo | 2012 | Neural Regeneration Research2012，7，25： | 2 |
| 14 | Photocatalytic decompositions of gaseous HCHO and methylene blue with highly ordered TiO_2 nanotube arrays显示文摘The highly ordered Ti O_2nanotubes(NTs) were fabricated by the anodic oxidation method.Their morphology,structure and crystalline phase were characterized by scanning electron microscopy(SEM) and X-ray diffractometer(XRD).The effects of morphology,specific surface area,pore structures and photocatalytic activity of the Ti O_2 NTs were investigated.UV–vis spectra analysis showed that its light absorption had been extended to the visible light range.The photocatalytic activity of the as-prepared samples was evaluated by photocatalytic oxidation of gaseous HCHO and MB aqueous solution.The samples had better adhesion strength in the dark and showed a higher photocatalytic activity than nanoparticles.Especially,with ultraviolet light pretreatment,the nanotubes exhibited more stable active for photocatalytic decomposition and the photodecomposition rate remained at high level after 3 cycles of the photocatalysis experiment.Thus,how the number of surface active group ·OH increased and the mechanism for the great improvement for the photocatalytic activity are discussed. | Lixia Li Jing Ya Fengjiao Hu Zhifeng Liu Lei E | 2016 | Journal of Energy Chemistry2016，25，4： | 2 |
| 15 | 制药企业药品上市前安全风险管理显示文摘1药物警戒的必要性良好的药物警戒是最理想的药品风险管理方式,它可以最大程度的了解某种药品的所有信息,并且发现它潜在的安全问题,甚至有可能发现其预料之外的好处。鉴于这个理念,新化学实体(newchemical entity)在研发初期就必须进行动物和人体安全性测试,以便更好地促进并保护公众健康。中国古话所说的"是药三分毒", | Judith K Jones Elyse E Kingery Jing Tao Jeff J Guo | 2013 | 药物流行病学杂志2013，22，5： | 2 |
| 16 | Thermally induced structural transformation of polytriazoleimide to polyindoleimide显示文摘包含 bisphenyl-1,2,3-triazole (BPT ) 的 polytriazoleimide 的一种新类型被叠氮化物和炔属羟和 polycondensation (CuAAC ) 的催化铜的 1,3-dipolar cycloaddition 综合。polytriazoleimide 的热稳定性和降级机制被调查。结果证明在 polytriazoleimide 的 BPT 的结构在热处理以后转变到 phenylindole,伴随 N2 的版本。 | Yan Peng E Li Qiang Wan Yu Jing Li Fa Rong Huang Lei Du | 2012 | Chinese Chemical Letters2012，23，9： | 2 |
| 17 | Experimental study on dispersive soil in western Jilin显示文摘In order to research engineering geological properties of the soil in Zhenlai of western Jilin,especially the dispersivity of soil,the authors carried out the basic physicochemical test and dispersivity identification test.The results show that the dispersivity of the soil increases with the increase of depth within 0-30 cm (surface soil);it decreases as the depth increases within in 30-100 cm.Furthermore,the statistical analysis of the dispersivity indexes and physicochemical propertity indexes show that the DP is positively linear correlated with total soluble salt content,sodium ion content,ESP,pH and organic matter content.Meanwhile,it is negatively linear correlated with clay content,and the linear relationship is better.Through the study of the dispersion mechanism of soil samples,it can be concluded that sodium montmorillonite,higher percentage of exchangeable sodium and high pH are the main reasons for the dispersion of soils in western Jilin. | ZHANG Jing WANG Qing WANG Wenhua CHEN Hui'e WANG Ying | 2010 | Global Geology2010，13，1： | 2 |
| 18 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 19 | Highly sensitive and specific microRNA expression profiling using BeadArray technology显示文摘 | CHEN Jing LOZACH J GARCIA E W | 2008 | Nucleic Acids Res2008，36，14： | 1 |
| 20 | A full multigrid method for linear complementarity problems arising from elastic normal, contact problems 显示文摘 | ZHAO Jing VOLLEBREGT E A H OOSTERLEE C W | 2014 | Mathematical Modelling and Analysis2014，19，2： | 1 |
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